Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Tsunetaka Ohta"'
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30007 (2012)
Beta-amyloid (Aβ) peptides are considered to play a major role in the pathogenesis of Alzheimer's disease (AD) and molecules that can prevent pathways of Aβ toxicity may be potential therapeutic agents for treatment of AD. We have previously report
Externí odkaz:
https://doaj.org/article/bdf5f9acce5d451a9d072326eda58eab
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17137 (2011)
BACKGROUND: Neurotrophic factors may be future therapeutic agents for neurodegenerative disease. In the screening of biologically active molecules for neurotrophic potency, we found that a photosensitizing cyanine dye, NK-4, had remarkable neurotroph
Externí odkaz:
https://doaj.org/article/629e93d203294d4d835dcdd8b86bc9b0
Autor:
Yasuda Akiko, Nagisa Sada, Yurika Shimizu, Suni Lee, Toshio Ariyasu, Satomi Miyata, Takemi Otsuki, Shin Endo, Bandaru Srinivas, Shoko Yamamoto, Yasumitsu Nishimura, Tsunetaka Ohta, Naoko Kumagai-Τakei, Akira Harashima, Tatsuo Ito
Publikováno v:
International Journal of Oncology
Exposure of human immune cells to asbestos causes a reduction in antitumor immunity. The present study aimed to investigate the recovery of reduced antitumor immunity by several ingredients taken as supplements or foods, including trehalose (Treh) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f6f7b612b6727a5457647cc9ab05f
https://doi.org/10.3892/ijo.2021.5182
https://doi.org/10.3892/ijo.2021.5182
Autor:
Mutsuko Taniguchi, Shigeharu Fukuda, Madoka Taniai, Toshio Ariyasu, Daiki Nagatomo, Miho Aga, Tsunetaka Ohta, Harumi Ariyasu
Publikováno v:
BioMed Research International, Vol 2015 (2015)
BioMed Research International
BioMed Research International
We encapsulated tumor necrosis factor-α(TNF-α), a major proinflammatory cytokine, into cholesteryl pullulan (CHP) to prepare TNF/CHP nanoparticles. In this report, we describe the immune-enhancing capability of the nanoparticles to act as a vaccine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147ba5a879f9fcd2c36d95c6254896f4
https://doi.org/10.1155/2015/471468
https://doi.org/10.1155/2015/471468
Autor:
Tsunetaka Ohta
Publikováno v:
Steps Forwards in Diagnosing and Controlling Influenza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a03bdcccb2f94f3306d0c688fc51f6
https://doi.org/10.5772/64366
https://doi.org/10.5772/64366
Autor:
Hitomi Ohta, Tsunetaka Ohta, Shigeharu Fukuda, Satomi Koya-Miyata, Toshio Kawata, Kenji Akita, Shigeyuki Arai
Publikováno v:
Biological and Pharmaceutical Bulletin. 33:1872-1877
Some photosensitizing cyanine dyes act on the immune system to enhance the phagocytic capacity of macrophages. In this study, we examined whether these dyes have neurotrophin-like activities and neuroprotective effects in vitro and in vivo. By screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101c799c6fd8e30cc609ea3ee56b2931
https://doi.org/10.1248/bpb.33.1872
https://doi.org/10.1248/bpb.33.1872
Autor:
Akiko Ohkawa, Kyoko Minowa, Yasuhiro Abe, Shin-ichi Tsunoda, Tetsuya Nomura, Shinsaku Nakagawa, Haruhiko Kamada, Yohei Mukai, Tsunetaka Ohta, Yasuo Yoshioka, Yasuo Tsutsumi, Hiroko Shibata, Madoka Taniai
Publikováno v:
Biomaterials. 30:6638-6647
Blocking the binding of TNF-alpha to TNF receptor subtype-1 (TNFR1) is an important strategy for the treatment of rheumatoid arthritis (RA). We recently succeeded in developing a TNFR1-selective antagonistic TNF mutant, R1antTNF. Here, we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a80d1fe84312a5b3f67deb427ff5951
https://doi.org/10.1016/j.biomaterials.2009.08.041
https://doi.org/10.1016/j.biomaterials.2009.08.041
Autor:
Kanso Iwaki, Shigeyuki Arai, Miho Aga, Tsunetaka Ohta, Emiko Ohashi, Shigeharu Fukuda, Norie Arai, Toshio Ariyasu
Publikováno v:
Nippon Shokuhin Kagaku Kogaku Kaishi. 56:31-39
わが国において，脂肪細胞の機能不全を起因の1つとする生活習慣病の増加に対してその予防は急務であり，食品因子からの予防が期待されている．本研究は，プロポリスエキスを対象と
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48e4dbdb961f09b82fc4c7bdff70f89e
https://doi.org/10.3136/nskkk.56.31
https://doi.org/10.3136/nskkk.56.31
Publikováno v:
Biomedical Research. 30:365-368
In this study, we demonstrate that a cyanine dye, lumin, significantly suppressed cytopathic effect by herpes simplex virus (HSV)-1 toward human amnionic FL cell and also it reduced replication of HSV-1 in a dose-dependent manner. In addition, lumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1a2221f40f7969fb5d6486e7e3db1b
https://doi.org/10.2220/biomedres.30.365
https://doi.org/10.2220/biomedres.30.365
Autor:
Hitomi Ohta, Chie Ushio, Tsunetaka Ohta, Harumi Ariyasu, Shigeharu Fukuda, Masashi Kurimoto, Toshio Ariyasu, Tohru Kayano, Miho Aga
Publikováno v:
Journal of Interferon & Cytokine Research. 28:359-366
In the present study, we describe the generation of a series of anti-interferon-alpha8 (IFN-alpha8)-specific monoclonal antibodies (mAbs), their characterization, and the establishment of a sandwich enzyme-linked immunosorbent assay (ELISA) system fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f5c06975f3e13e110b738961d63354
https://doi.org/10.1089/jir.2007.0121
https://doi.org/10.1089/jir.2007.0121