Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Tsuneo Omura"'
Autor:
Tsuneo, Omura
Publikováno v:
Drug Metabolism and Disposition. 50:1000-1001
The concept of hepatic induction of drug-metabolizing cytochrome P450s (P450s) by xenobiotics, including therapeutic drugs, was proposed in the early 1960s. A polycyclic aromatic hydrocarbon and phenobarbital have been the two major inducers used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b704c48fb23b714678ad9f01c79644b6
https://doi.org/10.1124/dmd.122.000891
https://doi.org/10.1124/dmd.122.000891
Autor:
Tsuneo Omura1 omurat@mxs.mesh.ne.jp, Osamu Gotoh2
Publikováno v:
Journal of Biochemistry. May2017, Vol. 161 Issue 5, p399-407. 9p.
Autor:
Tsuneo Omura
Publikováno v:
Journal of inorganic biochemistry. 186
Cytochrome P450 (P450) of eukaryotes and prokaryotes diversified remarkably during the long course of their evolution. Since the diversification of P450 was the consequence of the adaptation of various living organisms to diverse environmental change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96123006e17fa5f4672fcaea5ae36d21
https://pubmed.ncbi.nlm.nih.gov/29990750
https://pubmed.ncbi.nlm.nih.gov/29990750
Autor:
Tsuneo Omura
Publikováno v:
Biotechnology and Applied Biochemistry. 60:4-8
Emergence of eukaryotic cells in the ancient world of prokaryotic life was dependent on P450 as the synthesis of sterols, an essential constituent of the plasma membrane, required a P450-catalyzed reaction. As the ancestral monocellular eukaryotic or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6c523dd9b6bad2a80c5663f500d2e6
https://doi.org/10.1002/bab.1099
https://doi.org/10.1002/bab.1099
Autor:
Tsuneo Omura
Publikováno v:
The Journal of Biochemistry. 147:297-306
Cytochrome P450 enzyme system consists of P450 and its NAD(P)H-linked reductase or reducing system, and catalyses monooxygenation reactions. The most prevalent type in eukaryotic organisms is 'microsomes type', which consists of membrane-bound P450 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d33d2dcf3a34ed44c038a1b4da8ebb
https://doi.org/10.1093/jb/mvq001
https://doi.org/10.1093/jb/mvq001
Autor:
Tsuneo, Omura
Publikováno v:
Chemico-Biological Interactions. 163:86-93
Cytochrome P450 was first found in the microsomes from animal tissues, and then the presence of P450 in mitochondria was reported for the steroidogenic organs, adrenal gland and gonads. Three forms of mitochondrial P450 (11A, 11B1, and 11B2) were pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064e8b8eb1699655ff6246b46ee8a808
https://doi.org/10.1016/j.cbi.2006.06.008
https://doi.org/10.1016/j.cbi.2006.06.008
Autor:
Tsuneo Omura
Publikováno v:
Biochemical and Biophysical Research Communications. 338:404-409
Cytochrome P450 was the first hemoprotein found to have a thiolate anion as the axial ligand of the heme. Several other heme–thiolate proteins, including nitric oxide synthase, were later found in animals, plants, and microorganisms. Both cytochrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad59719f7a01270341b4b4292a4203ff
https://doi.org/10.1016/j.bbrc.2005.08.267
https://doi.org/10.1016/j.bbrc.2005.08.267
Autor:
Tsuneo Omura
Publikováno v:
Fifty Years of Cytochrome P450 Research ISBN: 9784431549918
Since the discovery of “cytochrome P450” in 1962, many biochemists have intensively studied various problems of this unique hemoprotein and contributed to the elucidation of its molecular properties and physiological functions. This review chapte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73ef4dc8a88c3192f3793de9c0faf731
https://doi.org/10.1007/978-4-431-54992-5_1
https://doi.org/10.1007/978-4-431-54992-5_1
Publikováno v:
Journal of Biochemistry. 129:271-277
All microsomal P450s have a proline-rich sequence (PR) in the amino-terminal region that is needed for proper folding [Kusano, K., Sakaguchi, M., Kagawa, N., Waterman, M.R. and Omura, T. (2001) J. Biochem., 129, 259-269]. There are also multiple prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddbc3e1ec6afa7fd7825802712672e0
https://doi.org/10.1093/oxfordjournals.jbchem.a002854
https://doi.org/10.1093/oxfordjournals.jbchem.a002854
Autor:
Tsuneo Omura
Publikováno v:
Seibutsu Butsuri. 41:181-185
The characteristic 450 nm spectrum of cytochrome P450 is highly sensitive to denaturation of the protein structure. It is a sensitive indicator of the native conformation of the heme-containing catalytic domain of P450 molecules, and can be convenien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c94d507323c64b8578d88eff83402dbd
https://doi.org/10.2142/biophys.41.181
https://doi.org/10.2142/biophys.41.181