Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Tsuneo Okutomi"'
1
Disposition of Q-35. (3). Transfer into Fetus and Milk in Rats
Autor: Ken Okano, Norihisa Ohishi, Satofumi Iida, Tsuneo Okutomi, Masaki Ishigai, Akira Okazaki, Toshito Nakagawa, Masami Hayashi, Yoshihiko Ishitani
Publikováno v: Drug Metabolism and Pharmacokinetics. 10:617-624
Transfer of radioactivity into fetus and milk were studied after a single oral administration of 14C-Q-35 at the dose of 20 mg/kg in pregnant and in lactating rats.1. Whole body autoradiography of pregnant rats showed that radioactivity distributed w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ed84b107ea6c3ecc09dc38f6418b35a
https://doi.org/10.2133/dmpk.10.617
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2
Disposition of Q-35. (1). Absorption and Excretion after Single Administration of 14C-Q-35 in Rats
Autor: Toshito Nakagawa, Masaki Ishigai, Kazumi Ohkubo, Tsuneo Okutomi, Akira Okazaki, Satofumi Iida
Publikováno v: Drug Metabolism and Pharmacokinetics. 10:595-603
The absorption and excretion of 14C labeled Q-35[(±)-1-Cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid], a new fluoroquinolone antimicrobial agent, were studied in rats.1. When 14C-Q-35 wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fe7cf4e5a0037c37632a165e0ef0882
https://doi.org/10.2133/dmpk.10.595
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5
Effect of ascofuranone on serum lipids of rats fed a cholesterol rich diet
Autor: Tsuneo Okutomi, Koji Suzuki, Tomoyoshi Hosokawa, Mikio Sawada, Kunio Ando
Publikováno v: Japanese journal of pharmacology. 25(1)
Ascofuranone, a fungal metabolite, significantly reduced serum lipid levels, when orally administered to male Wistar rats fed a cholesterol rich diet. The treatment also resulted in a marked reduction of hepatic and cardiac cholesterol contents witho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed3bc8bbd562129bac80550a2eaeb63
https://pubmed.ncbi.nlm.nih.gov/1152308
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6
Inhibition of nucleic acid biosynthesis in procaryotic and eucaryotic cells by cyanocycline A
Autor: Seikichi Suzuki, Tsuneo Okutomi, Hiroshi Okazaki, Toshiaki Hayashi
Publikováno v: The Journal of antibiotics. 36(9)
Cyanocycline A was cytotoxic against Meth A cells in vitro, and also showed marked activity against the same cell line grown as an experimental ascites tumor. This antibiotic inhibited nucleic acid synthesis in Escherichia coli and Meth A cells. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778f2c21f617e4f1c3c144e045766c35
https://pubmed.ncbi.nlm.nih.gov/6355040
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7
Hypolipidemic property of ascofuranone
Autor: Tsuneo Okutomi, Kunio Ando, Mikio Sawada, Tomoyoshi Hosokawa
Publikováno v: The Journal of antibiotics. 26(11)
Ascofuranone significantly reduced serum lipid levels of rats fed with normal diet 6 hours after a single oral administration of 108 mg/kg. When the antibiotic was orally given for consecutive 10 days to normolipidemic rats, the treatment resulted in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8711bb30143c66547bb22ec3ff4eb1e9
https://pubmed.ncbi.nlm.nih.gov/4792116
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