Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Tsuneo Oda"'
Autor:
Junya Shirai, Yoshiyuki Fukase, Tetsuji Kawamoto, Mitsunori Kono, Tsuneo Oda, Mikio Shirasaki, Yasushi Fujitani, Hiroyuki Watanabe, Hideyuki Nakagawa, Keiko Uga, Michiko Tawada, Naohiro Taya, Akira Shibata, Takashi Imada, Yoshihide Tomata, Masashi Yamasaki, Tomoya Yukawa, Shoji Fukumoto, Hidekazu Tokuhara, Satoshi Yamamoto, Naoki Ishii, Atsuko Ochida, Yoshihiro Banno
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:470-482
A series of tetrahydroisoquinoline derivatives were designed, synthesized, and evaluated for their potential as novel orally efficacious retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of Th17-driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525a6e1c5124e88399900d795fac2e06
https://doi.org/10.1016/j.bmc.2017.12.008
https://doi.org/10.1016/j.bmc.2017.12.008
Autor:
Masashi Yamasaki, Ayumu Sato, Tsuneo Oda, Gyorgy Snell, Junya Shirai, Yoshiyuki Fukase, Bi-Ching Sang, Keiko Uga, Atsuko Ochida, Yusuke Sasaki, Hideyuki Nakagawa, Akira Shibata, Satoshi Yamamoto, Naoki Ishii, Yoshihide Tomata, Shoji Fukumoto, Mikio Shirasaki, Isaac Hoffman, Mitsunori Kono, Robert J. Skene, Yumi N. Imai
Publikováno v:
ChemMedChem. 14(22)
Retinoic-acid-related orphan receptor γt (RORγt) inverse agonists could be used for the treatment of autoimmune diseases. Previously, we reported a novel quinazolinedione 1 a with a flexible linear linker as a novel RORγt inverse agonist. A U-shap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c774a9c6a16ee109cae218661d3aa241
https://pubmed.ncbi.nlm.nih.gov/31659845
https://pubmed.ncbi.nlm.nih.gov/31659845
Autor:
Naohiro Taya, Chien-Hung Chen, Tsuneo Oda, Bi-Ching Sang, Tomoya Yukawa, Takayuki Sato, Yoshi Nara, Noriko Uchiyama, Zenyu Shiokawa, Terufumi Takagi, Satoshi Yamamoto, Ayumu Sato, Ryokichi Koyama, Nobuyuki Negoro, Gyorgy Snell, Junya Shirai, Ryosuke Katsuyama, Takashi Imada, Yoshihiro Banno, Isaac Hoffman, Tetsuji Kawamoto, Mitsunori Kono, Robert J. Skene
Publikováno v:
Journal of medicinal chemistry. 62(3)
Retinoic acid receptor-related orphan receptor γt (RORγt) agonists are expected to provide a novel class of immune-activating anticancer drugs via activation of Th17 cells and Tc17 cells. Herein, we describe a novel structure-based functionality sw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1871e7ef2034f04a5ead2918edf01322
https://pubmed.ncbi.nlm.nih.gov/30652849
https://pubmed.ncbi.nlm.nih.gov/30652849
Autor:
Keiko Igaki, Yoshihiro Banno, Tsuneo Oda, Akira Shibata, Bi-Ching Sang, Masashi Yamasaki, Hideyuki Nakagawa, Atsuko Ochida, Hidekazu Tokuhara, Kazuko Yonemori, Junya Shirai, Satoshi Yamamoto, Yoshiyuki Fukase, Gyorgy Snell, Shinichi Masada, Tomoya Yukawa, Yoshi Nara, Isaac Hoffman, Tetsuji Kawamoto, Mitsunori Kono, Noboru Tsuchimori, Yoshiki Nakamura, Keiko Uga, Takashi Imada, Naohiro Taya, Robert J. Skene
Publikováno v:
Journal of medicinal chemistry. 61(7)
A series of tetrahydronaphthyridine derivatives as novel RORγt inverse agonists were designed and synthesized. We reduced the lipophilicity of tetrahydroisoquinoline compound 1 by replacement of the trimethylsilyl group and SBDD-guided scaffold exch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9548ec5d97f7b04e014802ee8f90a5b0
https://pubmed.ncbi.nlm.nih.gov/29510038
https://pubmed.ncbi.nlm.nih.gov/29510038
Autor:
Keishi Shimada, Yujiro Kitade, Shigeru Aoki, Kohei Mizobata, Lingqiao Cheng, Kunio T. Takahashi, Ryosuke Makabe, Jota Kanda, Tsuneo Odate
Publikováno v:
Communications Earth & Environment, Vol 3, Iss 1, Pp 1-9 (2022)
Under rapid and persistent freshening in source waters, a decline in the supply of Antarctic Bottom Water to the Australian-Antarctic Basin is compensated by an increase in ventilation of the layer immediately above, suggests an analysis of in situ o
Externí odkaz:
https://doaj.org/article/7b3501fa38f54fdf8a521e26abf82f03
Autor:
Katsuji Aikawa, Yoshio Aramaki, Yuji Iizawa, Masanori Baba, Tsuneo Oda, Mitsuru Shiraishi, Naoyuki Kanzaki, Masaki Seto, Hiroshi Imoto
Publikováno v:
Chemical and Pharmaceutical Bulletin. 52:818-829
In order to develop orally active CCR5 antagonists, we investigated 1-benzoxepine derivatives containing new polar substituents, such as phosphonate, phosphine oxide or pyridine N-oxide moieties, as replacements for the previously reported quaternary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbac99c70a445eafcc7c43663be1b35
https://doi.org/10.1248/cpb.52.818
https://doi.org/10.1248/cpb.52.818
Autor:
Mitsunori Kono, Atsuko Ochida, Tsuneo Oda, Takashi Imada, Yoshihiro Banno, Naohiro Taya, Shinichi Masada, Tetsuji Kawamoto, Kazuko Yonemori, Yoshi Nara, Yoshiyuki Fukase, Tomoya Yukawa, Hidekazu Tokuhara, Skene, Robert, Bi-Ching Sang, Hoffman, Isaac D., Snell, Gyorgy P., Keiko Uga, Akira Shibata, Keiko Igaki
Publikováno v:
Journal of Medicinal Chemistry; 4/12/2018, Vol. 61 Issue 7, p2973-2988, 16p
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 613:43-49
An on-line urine clean-up system was developed for the simultaneous determination of free and total pyridinoline, hydroxylysyl-pyridinoline (HP) and lysylpyridinoline (LP) by high-performance liquid chromatography (HPLC) using a column-switching tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2449ea35d31ee8c4fb9cb122a33c5d
https://doi.org/10.1016/0378-4347(93)80195-a
https://doi.org/10.1016/0378-4347(93)80195-a
Autor:
Atsuo Baba, Tsuneo Oda, Takashi Sohda, Haruhiko Makino, Kohei Notoya, Atsushi Nishimura, Shigehisa Taketomi
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::297c45e3c5e490abc08c931007ae77ea
https://doi.org/10.1002/chin.199942153
https://doi.org/10.1002/chin.199942153
Autor:
Yuji Iizawa, Masanori Baba, Yoshio Aramaki, Tsuneo Oda, Katsuji Aikawa, Masaki Seto, Hiroshi Imoto, Naoyuki Kanzaki, Mitsuru Shiraishi
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::017a804333d371df723edef1be73952d
https://doi.org/10.1002/chin.200451140
https://doi.org/10.1002/chin.200451140