Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tsuneo Deguchi"'
Autor:
Kaoru Kobayashi, Tsuneo Deguchi, Satoshi Abe, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Atsushi Kurihara, Mitsuo Oshimura, Yasuhiro Kazuki
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 6, Pp n/a-n/a (2022)
Abstract UDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constru
Externí odkaz:
https://doaj.org/article/8792878571ce483887e7d51d35ed617c
Autor:
Kaoru Kobayashi, Tsuneo Deguchi, Satoshi Abe, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Atsushi Kurihara, Mitsuo Oshimura, Yasuhiro Kazuki
Publikováno v:
Pharmacology Research & Perspectives. 10
UDP-glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1a94cdfe2bedd50f63d35afa44f622
https://doi.org/10.1002/prp2.1030
https://doi.org/10.1002/prp2.1030
Autor:
Satoshi Watanabe, Takayoshi Fukushima, Yusuke Matsuo, Takahito Morimoto, Tsuneo Deguchi, Keisuke Fukumuro, Yu Sawai
Publikováno v:
Applied Microbiology; Volume 2; Issue 4; Pages: 905-920
Deciphering the key factors underlying individual responses to a habitual diet is important in implementing personalized nutrition strategies to treat allergic diseases. This prospective randomized cohort study aimed to identify key factors determini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344a324a131f9b695c65d1f20d54df65
Autor:
Chungwen Wei, Benjamin G. Barwick, Jeremy M. Boss, Christopher D. Scharer, Bridget E. Neary, Tsuneo Deguchi, Iñaki Sanz, Tian Mi, Arezou Khosroshahi, F. Eun-Hyung Lee, Scott A. Jenks, Dillon G. Patterson, Emily L. Blalock, Sakeenah L. Hicks, Kevin S. Cashman
Publikováno v:
Nature immunology
Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular pathogenic B cells derived from newly activated naive cells. Although these cells express distinct markers, their epigenetic architecture and how it contributes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34abb8857af29ee011d71c48ba95799c
http://europepmc.org/articles/PMC6642679
http://europepmc.org/articles/PMC6642679
Autor:
Atsushi Yamasaki, Misa Ikuta, Manabu Abe, Tsuneo Deguchi, Yasuki Kamai, Kenji Nakamaru, Toshinori Agatsuma
Publikováno v:
Cancer Research. 82:5376-5376
Introduction: T-DXd (trastuzumab deruxtecan) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2) composed of a humanized anti-HER2 monoclonal antibody conjugated to a DNA topoisomerase I inhibitor, DXd throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24cdc7ddb95b281b00347e7ccfc18868
https://doi.org/10.1158/1538-7445.am2022-5376
https://doi.org/10.1158/1538-7445.am2022-5376
Autor:
Minori Osamura, Mitsuo Oshimura, Mari Hashimoto, Masato Takiguchi, Kanako Kazuki, Rika Hirashima, Naoto Senda, Nico Scheer, Daisuke Satoh, Takehito Kaneko, Yasuko Tsukazaki, Jiro Kuze, Naoyo Kajitani, Shoko Takehara, Yasuhiro Kazuki, Tsuneo Deguchi, Takashi Yamamoto, Tetsushi Sakuma, Riko Wakatsuki, Ryoichi Fujiwara, Satoshi Abe, Tomoji Mashimo, Kaoru Kobayashi, Masumi Hirabayashi, Atsushi Kurihara
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Genomically humanized animals overcoming species differences are invaluable for biomedical research. Although rats would be preferred over mice for several applications, generation of a humanized model is restricted to mice due to the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a6abe0e80c40a0d93fc48413bfcd08
https://pubmed.ncbi.nlm.nih.gov/30718425
https://pubmed.ncbi.nlm.nih.gov/30718425
Autor:
Kousei, Shimada, Yasuo, Ohata, Jun, Kobayashi, Yoshiyuki, Onishi, Asuka, Kawamura, Yuki, Domon, Naohisa, Arakawa, Tatsuya, Inoue, Yutaka, Kitano, Fumihiko, Matsuda, Yuki, Abe, Tsuneo, Deguchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(11)
We identified novel (3R, 5S)-3-aminomethyl-5-methanesulfanyl hexanoic acid (5a: DS75091588) and (3R, 5S)-3-aminomethyl-5-ethanesulfanyl hexanoic acid (6a: DS18430756) as sulfur-containing γ-amino acid derivatives that were useful for the treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c1e70a90bb98fa8e065cd38f9bceede
https://pubmed.ncbi.nlm.nih.gov/29752183
https://pubmed.ncbi.nlm.nih.gov/29752183
Autor:
Veronika Rozehnal, Ilona Schreck, Osamu Ando, Tsuneo Deguchi, Chie Makino, Hiroshi Yamazaki, Nobuaki Watanabe, Hideyuki Shiozawa, Akiko Watanabe, Tomoko Ishizuka, Norie Murayama
A 1,2,4-oxadiazole ring-containing compound DS-8500a was developed as a novel G protein-coupled receptor 119 agonist. In vivo metabolic fates of [14C]DS-8500a differently radiolabeled in the benzene ring or benzamide side carbon in rats were investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8f1ae2301ed630b4a364b1d890d9ea
Autor:
Christopher Scharer, Emily Blalock, Tian Mi, Benjamin Barwick, Scott Jenks, Bridget Neary, Dillon Patterson, Tsuneo Deguchi, Eun-Hyung Lee, Chungwen Wei, Ignacio Sanz, Jeremy M Boss
Publikováno v:
The Journal of Immunology. 202:50.10-50.10
Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular pathogenic B cells derived from newly activated naïve cells. Although these cells have distinct markers and phenotypes, their epigenetic architecture and how it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::307391d4a2e7eafdecf8409671a1310d
https://doi.org/10.4049/jimmunol.202.supp.50.10
https://doi.org/10.4049/jimmunol.202.supp.50.10
Autor:
Yoshitake Furuta, Makiko Yamada, Nobuhisa Masuda, Minoru Uchiyama, Koichi Yabe, Shin-ichi Inoue, Tsuneo Deguchi
Publikováno v:
Open Forum Infectious Diseases
Background Clostridium difficile infection (CDI) is the most common cause of diarrhea in hospitals. The only available intravenous (IV) therapy for CDI is metronidazole, which showed only a 52.4% cure rate in a prospective observational study. DS1196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b58c612af63454b478bf7df3b8456d
http://europepmc.org/articles/PMC5631360
http://europepmc.org/articles/PMC5631360