Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tsunemichi Hosokawa"'
Autor:
Hideki Yamamoto, Tsunemichi Hosokawa, Yoshiro Tani, Koji Yamate, Yoko Kamai, Hatsue Mizuno, Kunio Doi
Publikováno v:
The Journal of Toxicological Sciences. 26:25-37
Mini rats are a transgenic rat strain carrying antisense gene for rat growth hormone (GH), resulting in retarded growth and a lower blood GH level (136 +/- 42.0 ng/mL) compared with that of age-matched parental strain Wistar rats (329 +/- 337 ng/mL).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f322fd4eac3f01b38119101a914a1b
https://doi.org/10.2131/jts.26.25
https://doi.org/10.2131/jts.26.25
Autor:
Yumiko Mori, Tsunemichi Hosokawa, Tatsuya Inoue, Tomihisa Yokoyoma, Yukio Sasaki, Hiroaki Yanagisawa, Hiroyuki Koike
Publikováno v:
Current Eye Research. 23:133-138
To evaluate the ocular hypotensive effect of topical CS-088, an angiotensin AT1 receptor antagonist, and the effect of CS-088 on aqueous humor dynamics.The effects of CS-088 on intraocular pressure (IOP) were studied in 2 models of rabbit ocular hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b229da18248cbc2fa30ce9338801e3fb
https://doi.org/10.1076/ceyr.23.2.133.5473
https://doi.org/10.1076/ceyr.23.2.133.5473
Publikováno v:
Journal of Toxicologic Pathology. 14:151-155
We have shown that the Mini rat, a transgenic rat strain carrying the antisense transgene for rat growth hormone, is a useful model to investigate the role of growth hormone in the expression of hepatic microsomal cytochrome P450s (CYPs). However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74acddd7446b845d84e88d3ccf2a4b47
https://doi.org/10.1293/tox.14.151
https://doi.org/10.1293/tox.14.151
Autor:
Hiroyoshi Horikoshi, Sayaka Takahashi, Junichiro Fukushige, Ogawa Junko, Shinichi Kurakata, Fujiwara Toshihiko, Takashi Izumi, Tsunemichi Hosokawa
Publikováno v:
Life Sciences. 65:1287-1296
Recent investigations suggest that cytotoxic cytokines such as tumor necrosis factor (TNF)alpha and interleukin (IL)-1beta or free radicals play an essential role in destruction of pancreatic beta cells in Type 1 diabetes and that, therefore, anti-ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e193fb69aec05ff3a1085b9e97123feb
https://doi.org/10.1016/s0024-3205(99)00364-1
https://doi.org/10.1016/s0024-3205(99)00364-1
Autor:
Kohji Tanaka, Yoshiro Tani, Shinya Sehata, Takashi Yamoto, Junichiro Fukushige, Tsunemichi Hosokawa, Toshihiko Makino, Naoyuki Maeda, Etsuji Matsumoto, Sunao Manabe, Hideki Yamamoto, Satoko Sato, Mayumi Watanabe, Kazuo Endo, Munehiro Teranishi, Seiya Ogata, Masaya Takaoka
Publikováno v:
Journal of Toxicologic Pathology. 12:119-129
Mini rats, a Wistar-derived transgenic rat strain harboring a rat growth hormone (GH) antisense gene, show lower plasma GH levels than Wistar rats. In our previous study, Mini rats showed a smaller femur size with lower mineral density and a reductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c4b7bded9d47e38de1113c592d61215
https://doi.org/10.1293/tox.12.119
https://doi.org/10.1293/tox.12.119
Autor:
Munehiro Teranishi, Seiya Ogata, Isao Igarashi, Toshihiko Makino, Hideki Yamamoto, Sunao Manabe, Kohji Tanaka, Shinya Sehata, Masaya Takaoka, Naoyuki Maeda, Takashi Yamoto, Kazuo Endo, Tsunemichi Hosokawa, Satoko Sato, Etsuji Matsumoto, Yoshiro Tani, Junichiro Fukushige, Mayumi Watanabe
Publikováno v:
Journal of Toxicologic Pathology. 12:131-140
Growth hormone (GH) plays an important role in longitudinal bone growth, and hypophysectomized rats have generally been used as a model for GH deficiency in humans. Recently, researchers have bred Mini rats, a Wistar-derived transgenic rat strain har
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::075b65b754f5db1aad0956f19a53b4e5
https://doi.org/10.1293/tox.12.131
https://doi.org/10.1293/tox.12.131
Autor:
Naoyuki Maeda, Sunao Manabe, Takashi Yamoto, Mayumi Watanabe, Satoko Sato, Isao Igarashi, Kohji Tanaka, Munehiro Teranishi, Toshihiko Makino, Seiya Ogata, Yoshiro Tani, Tsunemichi Hosokawa, Masaya Takaoka, Junichiro Fukushige, Kazuo Endo, Shinya Sehata, Etsuji Matsumoto, Hideki Yamamoto
Publikováno v:
Journal of Toxicologic Pathology. 12:183-190
Growth hormone (GH) plays an important role in longitudinal bone growth, and hypophysectomized rats or mutant rats exhibiting dwarfism have generally been used as a GH-deficient model for humans. There also has been a GH deficient model produced by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a841265dbb1d2c5bdbaf71e049c6aa2d
https://doi.org/10.1293/tox.12.183
https://doi.org/10.1293/tox.12.183
Autor:
Sunao Manabe, Junichiro Fukushige, Masaya Takaoka, Naoyuki Maeda, Takashi Yamoto, Yoshiro Tani, Tsunemichi Hosokawa, Satoko Sato, Toshihiko Makino, Shinya Sehata, Kohji Tanaka, Kazuo Endo, Munehiro Teranishi, Etsuji Matsumoto, Seiya Ogata, Hideki Yamamoto, Mayumi Watanabe
Publikováno v:
Journal of Toxicologic Pathology. 12:191-202
Mini rats have been reported to be a Wistar-derived strain of transgenic rats that harbors a rat growth hormone (GH) antisense gene and shows lower plasma GH levels than Wistar rats. Our previous study has revealed that: 1) Mini rats show smaller hin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90195501dbae2dc63a199eeac18d5b13
https://doi.org/10.1293/tox.12.191
https://doi.org/10.1293/tox.12.191
Autor:
Yoshiro Tani, Junichiro Fukushige, Koji Uetsuka, Sachiko Kajiwara, Shinji Murata, Hiroyuki Nakayama, Kunio Doi, Tsunemichi Hosokawa, Hatsue Mizuno
Publikováno v:
Journal of Toxicologic Pathology. 11:119-125
A histopathological study was carried out on the liver of thioacetamide (TAA)-treated rats of Jcl: Wistar-TgN(ARGHGEN)1Nts strain (Mini rats), in which the expression of growth hormone (GH) gene is suppressed by the presence of antisense transgene, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf83c511c6d53808b331eebbf147d0ee
https://doi.org/10.1293/tox.11.119
https://doi.org/10.1293/tox.11.119
Autor:
Yoko Kamai, Mikie Kubota, Yasuki Kamai, Scott G. Filler, Tsunemichi Hosokawa, Takashi Fukuoka
Publikováno v:
Infection and Immunity. 70:5256-5258
We investigated the contribution of Candida albicans ALS1 , which encodes a candidal adhesin, to the pathogenesis of experimental murine oropharyngeal candidiasis. Our results indicate that the ALS1 gene product is important for the adherence of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0fd1e905535d8c8cd0cd03511a29c5
https://doi.org/10.1128/iai.70.9.5256-5258.2002
https://doi.org/10.1128/iai.70.9.5256-5258.2002