Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Tsunehito, Higashi"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 1, Pp 22-25 (2023)
Cigarette smoking is a risk factor for respiratory infection caused by immune cell dysfunction. Cigarette smoke is divided into tar and gas phases. Although the gas phase induces cell death in various cell types, the mechanism for gas phase-induced c
Externí odkaz:
https://doaj.org/article/6aa82a0400d54315a3a36208e76315d5
Autor:
Yuichi Mazaki, Yasuhito Onodera, Tsunehito Higashi, Takahiro Horinouchi, Tsukasa Oikawa, Hisataka Sabe
Publikováno v:
Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-10 (2017)
Abstract Background The small GTPase ARF1 mediates membrane trafficking mostly from the Golgi, and is essential for the G protein-coupled receptor (GPCR)-mediated chemotaxis of neutrophils. In this process, ARF1 is activated by the guanine nucleotide
Externí odkaz:
https://doaj.org/article/d63fb7f8a8a2413fb303a405597c31e2
Autor:
Hitoshi Kashiwagi, Koh-ichi Yuhki, Yoshitaka Imamichi, Fumiaki Kojima, Shima Kumei, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa, Shuh Narumiya, Fumitaka Ushikubi
Publikováno v:
TH Open, Vol 01, Iss 02, Pp e122-e129 (2017)
The results of studies that were performed to determine whether cigarette smoking affects platelet function have been controversial, and the effects of nicotine- and tar-free cigarette smoke extract (CSE) on platelet function remain to be determined.
Externí odkaz:
https://doaj.org/article/fba1e4b6dccf43528bc4de002045df76
Publikováno v:
Journal of Pharmacological Sciences, Vol 123, Iss 2, Pp 85-101 (2013)
The endothelin (ET) system consists of two G protein coupled–receptors (GPCRs), ET type A receptor (ETAR) and ET type B receptor (ETBR), and three endogenous ligands, ET-1, ET-2, and ET-3. Stimulation of ETRs with ET-1 induces an increase in intrac
Externí odkaz:
https://doaj.org/article/276126b17ff2494dafd86c9ff802f16d
Autor:
Sachihiro Matsunaga, Hideaki Takata, Akihiro Morimoto, Kayoko Hayashihara, Tsunehito Higashi, Kouhei Akatsuchi, Eri Mizusawa, Mariko Yamakawa, Mamoru Ashida, Tomoko M. Matsunaga, Takachika Azuma, Susumu Uchiyama, Kiichi Fukui
Publikováno v:
Cell Reports, Vol 1, Iss 4, Pp 299-308 (2012)
Cohesion is essential for the identification of sister chromatids and for the biorientation of chromosomes until their segregation. Here, we have demonstrated that an RNA-binding motif protein encoded on the X chromosome (RBMX) plays an essential rol
Externí odkaz:
https://doaj.org/article/8afe847aad06443ca154bc83dfc1b39f
Autor:
Yosuke Mai, Tsunehito Higashi, Koji Terada, Chizuru Hatate, Prabha Nepal, Mika Horiguchi, Takuya Harada, Soichi Miwa, Takahiro Horinouchi
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 4, Pp 310-314 (2012)
Nicotine- and tar-free cigarette smoke extract (CSE) is reported to induce cell damage via activation of protein kinase C (PKC) and NADPH oxidase (NOX) in rat C6 glioma cells. Here we determined PKC isozyme(s) activated by CSE and their activation me
Externí odkaz:
https://doaj.org/article/5834ec6c718e48bd8a9bfdc0743fa03a
Autor:
Tsunehito Higashi, Hisataka Sabe, Yuichi Mazaki, Shingo Takada, Yasuhito Onodera, Junko Nio-Kobayashi, Satoshi Maekawa
Publikováno v:
Biochemical and Biophysical Research Communications. 513:708-713
Neutrophils rapidly migrate to infection sites after the recognition of invaders. During chemotaxis, neutrophils require energy supplied by mitochondria oxidative phosphorylation (OXPHOS), whereas neutrophils rely heavily on glycolysis under normal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef9ae13d2e0c0860946a0aa92b4ff5c
https://doi.org/10.1016/j.bbrc.2019.04.037
https://doi.org/10.1016/j.bbrc.2019.04.037
Publikováno v:
Biochemical and Biophysical Research Communications. 511:69-72
The overexpression of endothelin (ET)-1 or ET receptors (ETRs) is related to initiation and progression of tumor. In cancer cells, ET-1 activates various signaling pathways, including mitogen-activated protein kinase, phosphatidylinositol 3-kinase, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e22b3149b8372fcd354d1eab4be2a76
https://doi.org/10.1016/j.bbrc.2019.02.040
https://doi.org/10.1016/j.bbrc.2019.02.040
Autor:
Tsunehito Higashi, Yosuke Mai, Yoichi Noya, Takahiro Horinouchi, Koji Terada, Akimasa Hoshi, Prabha Nepal, Takuya Harada, Mika Horiguchi, Chizuru Hatate, Yuji Kuge, Soichi Miwa
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107856 (2014)
Cigarette smoke consists of tar and gas phase: the latter is toxicologically important because it can pass through lung alveolar epithelium to enter the circulation. Here we attempt to establish a standard method for preparation of gas phase extract
Externí odkaz:
https://doaj.org/article/c764a807973a401f8bc4832708c36f62
Autor:
Yu Ohmura, Tsunehito Higashi, Utano Tomaru, Tomoki Ito, Ruka Tomatsu, Masanori Kasahara, Yuji Kuge, Syota Miyajima, Mitsuhiro Yoshioka, Akihiro Ishizu, Kei Higashikawa
Publikováno v:
The American journal of pathology. 191(1)
Alzheimer disease (AD) is a progressive neurodegenerative disorder and the most common type of dementia worldwide. There is considerable evidence of age-related disruption of proteostasis being responsible for the development of AD. The proteasome is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2507d794ef233a5f1a4484a395c089
https://pubmed.ncbi.nlm.nih.gov/33339546
https://pubmed.ncbi.nlm.nih.gov/33339546