Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice.

Autor: Junji Okuda, Shinnichiro Niizuma, Tetsuo Shioi, Takao Kato, Yasutaka Inuzuka, Tsuneaki Kawashima, Yodo Tamaki, Akira Kawamoto, Yohei Tanada, Yoshitaka Iwanaga, Michiko Narazaki, Tetsuya Matsuda, Souichi Adachi, Tomoyoshi Soga, Genzou Takemura, Hiroshi Kondoh, Toru Kita, Takeshi Kimura

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72173 (2013)

BACKGROUND: Heart failure is associated with changes in cardiac energy metabolism. Glucose metabolism in particular is thought to be important in the pathogenesis of heart failure. We examined the effects of persistent overexpression of phosphoglycer

Externí odkaz: https://doaj.org/article/2fcfa27192c649699058d616c584bc86

Effect of persistent activation of phosphoinositide 3-kinase on heart

Autor: Yuki Yoshida, Yasutaka Inuzuka, Toru Kita, Tsuneaki Kawashima, Yoshitaka Iwanaga, Shinichiro Niizuma, Takao Kato, Rie Kosugi, Tetsuo Shioi, Tohru Izumi, Takeshi Kimura, Kayo Watanabe-Maeda, Yoji Machida, Shingo Tsuji, Hiroyuki Aburatani, Yodo Tamaki, Junji Okuda

Publikováno v: Life Sciences. 90:619-628

Aims Insulin/insulin-like growth factor-1 (IGF-1) signaling plays an important role in many biological processes. The class IA isoform of phosphoinositide 3-kinase (PI3K) is an important downstream effector of the insulin/IGF-1 signaling pathway. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c330a299c0226a3dd4c489ad1c1820e2
https://doi.org/10.1016/j.lfs.2012.02.010

MURC, a Muscle-Restricted Coiled-Coil Protein That Modulates the Rho/ROCK Pathway, Induces Cardiac Dysfunction and Conduction Disturbance

Autor: Naofumi Takehara, Takehiro Ogata, Koji Isodono, Tsuneaki Kawashima, Hiroaki Matsubara, Tomosaburo Takahashi, Tomomi Ueyama, Hidemasa Oh, Koichiro Harada, Tetsuo Shioi, Masashi Tagawa

Publikováno v: Molecular and Cellular Biology. 28:3424-3436

We identified a novel muscle-restricted putative coiled-coil protein, MURC, which is evolutionarily conserved from frog to human. MURC was localized to the cytoplasm with accumulation in the Z-line of the sarcomere in the murine adult heart. MURC mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bff6a69d8724ab008cac4cd4e7f3d2d
https://doi.org/10.1128/mcb.02186-07

Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts

Autor: Shunichi Miyazaki, Yoshitaka Iwanaga, Shinichiro Niizuma, Kazuhiro Kobuke, Takao Kato, Tsuneaki Kawashima, Taka-aki Koshimizu, Søren P. Sheikh, Takahiro Horie, Yasutaka Inuzuka, Takeshi Kimura, Yasumitsu Akahashi, Noona Ambartsumian, Eugene Lukanidin, Toru Takase, Yodo Tamaki, Hanako Morooka, Tetsuo Shioi, Koh Ono

Publikováno v: Tamaki, Y, Iwanaga, Y, Niizuma, S, Kawashima, T, Kato, T, Inuzuka, Y, Horie, T, Morooka, H, Takase, T, Akahashi, Y, Kobuke, K, Ono, K, Shioi, T, Sheikh, S P, Ambartsumian, N, Lukanidin, E, Koshimizu, T-A, Miyazaki, S & Kimura, T 2013, ' Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts ', Journal of Molecular and Cellular Cardiology, vol. 57, pp. 72-81 . https://doi.org/10.1016/j.yjmcc.2013.01.007

Metastasis-associated protein, S100A4 is suggested as a marker for fibrosis in several organs. It also modulates DNA binding of p53 and affects its function. However, the functional role of S100A4 in the myocardium has remained unclear. Therefore, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1826b4c0cfd2100fa89544315a812d95
https://pubmed.ncbi.nlm.nih.gov/23352991

Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure

Autor: Yasutaka Inuzuka, Yodo Tamaki, Toru Kita, Takao Kato, Yoshitaka Iwanaga, Shinichiro Niizuma, Takeshi Kimura, Tomoyoshi Soga, Michiko Narazaki, Junji Okuda, Tsuneaki Kawashima, Tetsuo Shioi, Tetsuya Matsuda

Publikováno v: Circulation. Heart failure. 3(3)

Background— Congestive heart failure (CHF) is associated with a change in cardiac energy metabolism. However, the mechanism by which this change is induced and causes the progression of CHF is unclear. Methods and Results— We analyzed the cardiac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4560da01e1d43c1b104c7777d881fa7e
https://pubmed.ncbi.nlm.nih.gov/20176713