Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Tsuneaki Asai"'
Supplementary Fig. S6 from Humanized ADEPT comprised of an engineered human purine nucleoside phosphorylase and a tumor targeting peptide for treatment of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ad51480d17ddfdc49200045cea2c74
https://doi.org/10.1158/1535-7163.22482179
https://doi.org/10.1158/1535-7163.22482179
Immunogenicity caused by the use of nonhuman enzymes in antibody-directed enzyme prodrug therapy has limited its clinical application. To overcome this problem, we have developed a mutant human purine nucleoside phosphorylase, which, unlike the wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d8ef06395bc12c71e6e034b59269fe
https://doi.org/10.1158/1535-7163.c.6530849
https://doi.org/10.1158/1535-7163.c.6530849
Supplementary Data from Humanized ADEPT comprised of an engineered human purine nucleoside phosphorylase and a tumor targeting peptide for treatment of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2087d7ccac4f6486b625934e900b8f
https://doi.org/10.1158/1535-7163.22482197.v1
https://doi.org/10.1158/1535-7163.22482197.v1
Publikováno v:
Molecular Cancer Therapeutics. 8:185-193
Immunogenicity caused by the use of nonhuman enzymes in antibody-directed enzyme prodrug therapy has limited its clinical application. To overcome this problem, we have developed a mutant human purine nucleoside phosphorylase, which, unlike the wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7523a77393cd39d1ed90a638fba921f1
https://doi.org/10.1158/1535-7163.mct-08-0652
https://doi.org/10.1158/1535-7163.mct-08-0652
Autor:
Julia Dewdney, Julia M. Plotnikov, Kris A. Blee, Laurence V. Bindschedler, Julie M. Stone, Chris Gerrish, Carine Denoux, G. Paul Bolwell, Frederick M. Ausubel, Dewi R. Davies, Tsuneaki Asai, Tezni Hayes
Publikováno v:
The Plant Journal. 47:851-863
The oxidative burst is an early response to pathogen attack leading to the production of reactive oxygen species (ROS) including hydrogen peroxide. Two major mechanisms involving either NADPH oxidases or peroxidases that may exist singly or in combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e185bc9602a45751701e2198a26ddde8
https://doi.org/10.1111/j.1365-313x.2006.02837.x
https://doi.org/10.1111/j.1365-313x.2006.02837.x
Publikováno v:
Journal of Immunological Methods. 299:63-76
We have previously demonstrated that an antibody-avidin fusion protein could be used to deliver biotinylated enzymes to tumor cells for antibody-directed enzyme prodrug therapy. However, the presence of the chicken protein avidin suggests that immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669f8e934b2ba12a23e3eb7a4caef9f2
https://doi.org/10.1016/j.jim.2005.01.020
https://doi.org/10.1016/j.jim.2005.01.020
Autor:
Tsuneaki Asai, Heard Jacqueline, Yelena Kovtun, Frederick M. Ausubel, Julie M. Stone, Peter Yorgey, Jen Sheen
Publikováno v:
The Plant Cell. 12:1823-1835
We have established an Arabidopsis protoplast model system to study plant cell death signaling. The fungal toxin fumonisin B1 (FB1) induces apoptosis-like programmed cell death (PCD) in wild-type protoplasts. FB1, however, only marginally affects the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff044ad4bc19d775eb5ac78557fb5d7
https://doi.org/10.1105/tpc.12.10.1823
https://doi.org/10.1105/tpc.12.10.1823
Publikováno v:
Proceedings of the National Academy of Sciences. 96:8973-8978
The downstream box (DB) is a sequence element that enhances translation of several bacterial and phage mRNAs. It has been proposed that the DB enhances translation by base pairing transiently to bases 1469–1483 of 16S rRNA, the so-called anti-DB, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc821d45fd0fed93b96621a1ff26fdb
https://doi.org/10.1073/pnas.96.16.8973
https://doi.org/10.1073/pnas.96.16.8973
Publikováno v:
Proceedings of the National Academy of Sciences. 96:1971-1976
Current global phylogenies are built predominantly on rRNA sequences. However, an experimental system for studying the evolution of rRNA is not readily available, mainly because the rRNA genes are highly repeated in most experimental organisms. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e20c6cf334df1559a4a2c6e54f4f60fc
https://doi.org/10.1073/pnas.96.5.1971
https://doi.org/10.1073/pnas.96.5.1971
Publikováno v:
Molecular Microbiology. 29:671-675
Initiation of chromosome replication is a key event in the life cycle of any organism. Little is known, however, about the regulatory mechanisms of this vital process. Conventionally, the initiation mechanism of chromosome replication in microorganis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d98816bc787a7d6c0ae569e35667a8
https://doi.org/10.1046/j.1365-2958.1998.00901.x
https://doi.org/10.1046/j.1365-2958.1998.00901.x