Výsledky vyhledávání - "Tsun P. Au Yeung"

Supplemental Materials and Methods from Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Description of BT-984 synthesis and LC-MS/MS sample preparation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bee5c3a9b68ce367ede19f13dc1c698
https://doi.org/10.1158/1535-7163.22506001

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Supplemental Figure S3 from Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Pharmacokinetic analysis of PEN-221 and DM1 in non-tumor bearing mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba22bdfd82befebd5572cd48a27bdaf
https://doi.org/10.1158/1535-7163.22506007

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Supplemental Figure S1 from Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

SSTR2 expression analysis in xenograft tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d899304168a8b71603d60e73191077f4
https://doi.org/10.1158/1535-7163.22506013.v1

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Supplemental Table S1 from Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Immunohistochemical Analysis of SSTR2 Expression in 44 Small Cell Lung Cancer Patient Samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141bccd89c5c35a519cf8c28637438ec
https://doi.org/10.1158/1535-7163.22505998.v1

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Supplemental Figure S4 from Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Body weight (BW) and health observations for efficacy studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3248e730eaf2c8a4ee1d30e00eeb65de
https://doi.org/10.1158/1535-7163.22506004

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Supplemental Figure S2 from Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

In vitro inhibition of proliferation of SCLC cells by PEN-221 or DM1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4212c28310c2e0e3bfc21ede1e3380d9
https://doi.org/10.1158/1535-7163.22506010.v1

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Supplemental Table S2 from Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Immunohistochemical Analysis of SSTR2 Expression in 35 Small Cell Lung Cancer Patient Samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffa3d49115631c63d9d58915a516d65
https://doi.org/10.1158/1535-7163.22505995

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Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

Publikováno v: Molecular cancer therapeutics. 18(11)

Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma with a 95% mortality rate with no improvement to treatment in decades, and new therapies are desperately needed. PEN-221 is a miniaturized peptide–drug conjugate (∼2 kDa) des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d86567212741ac5bc34184a27e4c30
https://pubmed.ncbi.nlm.nih.gov/31649014

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