Zobrazeno 1 - 10
of 465
pro vyhledávání: '"Tsukasa Seya"'
Publikováno v:
Cells, Vol 12, Iss 11, p 1504 (2023)
Viral infections are usually accompanied by systemic cytokinemia. Vaccines need not necessarily mimic infection by inducing cytokinemia, but must induce antiviral-acquired immunity. Virus-derived nucleic acids are potential immune-enhancers and parti
Externí odkaz:
https://doaj.org/article/ac61d3bd0c3d473ba7b9feb9578e673a
Autor:
Tsukasa Seya
Publikováno v:
Cells, Vol 12, Iss 3, p 371 (2023)
The evolution of the human species is the result of genetic variation [...]
Externí odkaz:
https://doaj.org/article/8d3913d09205451993d2464aed7ec94e
Publikováno v:
Cells, Vol 11, Iss 24, p 4006 (2022)
The vertebrate immune system functions to eliminate invading foreign nucleic acids and foreign proteins from infectious diseases and malignant tumors. Because pathogens and cancer cells have unique amino acid sequences and motifs (e.g., microbe-assoc
Externí odkaz:
https://doaj.org/article/f73b85e8763d489a80f041b28bce3fe7
Autor:
Junya Ono, Hiroaki Shime, Hiromi Takaki, Ken Takashima, Kenji Funami, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya
Publikováno v:
Journal of Biomedical Science, Vol 24, Iss 1, Pp 1-9 (2017)
Abstract Background Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+ mice. Microbiota also contains double-stranded RNA (dsRNA), a lig
Externí odkaz:
https://doaj.org/article/6c9f8f8b70c44fa89f5cf60678000e7f
Autor:
Takahisa Kouwaki, Masaaki Okamoto, Hirotake Tsukamoto, Yoshimi Fukushima, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract RIG-I and MDA5 are cytoplasmic viral RNA sensors that belong to the RIG-I-like receptors (RLRs), which induce antiviral innate immune responses, including the production of type I interferon and other pro-inflammatory cytokines. After recogn
Externí odkaz:
https://doaj.org/article/9be71f73eb1d49e9a5dea918b6fa101c
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1874-1887 (2017)
Cancer patients having anti-programmed cell death-1 (PD-1)/PD ligand 1 (L1)-unresponsive tumors may benefit from advanced immunotherapy. Double-stranded RNA triggers dendritic cell (DC) maturation to cross-prime antigen-specific cytotoxic T lymphocyt
Externí odkaz:
https://doaj.org/article/5e0b18602fea43ee9f6bc5388170677f
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cancer vaccines consist of a tumor-associated antigen (TAA) and adjuvant. These vaccines induce and activate proliferation of TAA-specific cytotoxic T lymphocytes (CTLs), suppressing tumor growth. The therapeutic efficacy of TAA-specific CTLs depends
Externí odkaz:
https://doaj.org/article/5c2e754d4f844f9fa8e29fb809094e0d
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mycoplasma fermentans-derived diacylated lipoprotein M161Ag (MALP404) is recognized by human/mouse toll-like receptor (TLR) 2/TLR6. Short proteolytic products including macrophage-activating lipopeptide 2 (MALP2) have been utilized as antitumor immun
Externí odkaz:
https://doaj.org/article/5390425c285746eb8fe11d733f2e0cd6
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs) suppress activation/proliferation of cytotoxic T cells, thereby hindering cancer immunotherapy. MDSCs are increased after adjuvant therapy with toll-like receptor (TLR) 2 ligands, such as Pam2CSK4,
Externí odkaz:
https://doaj.org/article/cd9136bf17a94ce0afd3e82f9f2ca37e
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Pattern recognition receptors (PRRs) play a crucial role in the innate immune system and contribute to host defense against microbial infection. PRR-mediated antimicrobial signals provide robust type-I IFN/cytokine production and trigger inflammation
Externí odkaz:
https://doaj.org/article/5afab374aabe45f08d50b96cacbee776