Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tsukasa Mizuhara"'
Publikováno v:
ACS Nano. 12:89-94
Early detection of biofilms is crucial for limiting infection-based damage. Imaging these biofilms is challenging: conventional imaging agents are unable to penetrate the dense matrix of the biofilm, and many imaging agents are susceptible to false p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b561c2f917196bee7baa9635a2894e73
https://doi.org/10.1021/acsnano.7b07496
https://doi.org/10.1021/acsnano.7b07496
Autor:
Sukru Gokhan Elci, Singyuk Hou, Vincent M. Rotello, Tsukasa Mizuhara, Gulen Yesilbag Tonga, Ngoc D. B. Le, Valery Normand, Huda A. Jerri, Richard W. Vachet, Daniel Benczedi
Publikováno v:
Particleparticle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems. 34(10)
Interactions between macromolecular systems and biosurfaces are complicated by the complexity of these multivalent interactions and challenges in quantifying affinities. In this study, a library of gold nanoparticles (AuNPs) with different functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e230f6b0fa86ff6be643995503b21a2
https://pubmed.ncbi.nlm.nih.gov/30410221
https://pubmed.ncbi.nlm.nih.gov/30410221
Autor:
Bradley Duncan, Xing-Jie Liang, Daniel F. Moyano, Vincent M. Rotello, Riddha Das, Shuaidong Huo, Ying Jiang, Singyuk Hou, Yi-Wei Lee, Tsukasa Mizuhara
Publikováno v:
ACS Nano. 9:9986-9993
Correlation of the surface physicochemical properties of nanoparticles with their interactions with biosystems provides key foundational data for nanomedicine. We report here the systematic synthesis of 2, 4, and 6 nm core gold nanoparticles (AuNP) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48f5a9bf81a52063d58b8c15f3dfd3b
https://doi.org/10.1021/acsnano.5b03521
https://doi.org/10.1021/acsnano.5b03521
Autor:
Tsukasa Mizuhara, Bo Yan, Yi-Cheun Yeh, Sung Tae Kim, Youngdo Jeong, Singyuk Hou, Vincent M. Rotello, Bradley Duncan, Riddha Das, Rubul Mout, Gulen Yesilbag Tonga
Publikováno v:
Nature Chemistry. 7:597-603
Bioorthogonal catalysis broadens the functional possibilities of intracellular chemistry. Effective delivery and regulation of synthetic catalytic systems in cells are challenging due to the complex intracellular environment and catalyst instability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17af99193ccbbb96bcbeaacf675123b0
https://doi.org/10.1038/nchem.2284
https://doi.org/10.1038/nchem.2284
Binding studies of cucurbit[7]uril with gold nanoparticles bearing different surface functionalities
Autor:
Krishnendu Saha, Gulen Yesilbag Tonga, Ziwen Jiang, Riddha Das, Singyuk Hou, Tsukasa Mizuhara, Vincent M. Rotello
Publikováno v:
Tetrahedron Letters. 56:3653-3657
Host–guest interactions between a synthetic receptor, cucurbit[7]uril (CB[7]), and gold nanoparticles (AuNPs) have been quantified using isothermal titration calorimetry. AuNPs were functionalized with ligands containing tertiary or quaternary benz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff4e210347874156d9bd8a39b8b1987
https://doi.org/10.1016/j.tetlet.2015.04.125
https://doi.org/10.1016/j.tetlet.2015.04.125
Autor:
Gulen Yesilbag Tonga, Bo Yan, Vincent M. Rotello, Tsukasa Mizuhara, Singyuk Hou, Patrick W. Fedick, Felix S. Alfonso, Yi-Cheun Yeh, Richard W. Vachet
Publikováno v:
Analytical Chemistry
Synthetic host–guest chemistry is a versatile tool for biomedical applications. Characterization and detection of host–guest complexes in biological systems, however, is challenging due to the complexity of the biological milieu. Here, we describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119050c6e8757be8b49cb57971fcf4d8
http://europepmc.org/articles/PMC4082387
http://europepmc.org/articles/PMC4082387
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2079-2087
To investigate the mechanism of action of the potent antiviral compound PD 404182, three novel photoaffinity probes equipped with a biotin or alkyne indicator were designed and synthesized based on previous structure–activity relationship studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7e0419f281fde67ac4a3aa65bd9d8f
https://doi.org/10.1016/j.bmc.2013.01.016
https://doi.org/10.1016/j.bmc.2013.01.016
The surface properties of nanoparticles (NPs) dictate their interaction with the outside world. The use of precisely designed molecular ligands to control NP surface properties provides an important toolkit for modulating their interaction with biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c01aa89595c72de3578a9f0c5019b60
https://europepmc.org/articles/PMC4847953/
https://europepmc.org/articles/PMC4847953/
Publikováno v:
Bioorganic & medicinal chemistry. 20(21):6434-6441
3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine (PD 404182) is an antiretroviral agent with submicromolar inhibitory activity against human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. In the current study, the structure–activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6c845a9148a548b9e4f495991b62c6
http://hdl.handle.net/2433/161054
http://hdl.handle.net/2433/161054
Autor:
Nobutaka Fujii, Kazuya Shimura, Hiroaki Ohno, Shiho Okazaki, Shinya Oishi, Hiroto Murayama, Masao Matsuoka, Tsukasa Mizuhara
Publikováno v:
Bioorganicmedicinal chemistry. 23(7)
3, 4-Dihydro-2H-benzo[4, 5]isothiazolo[2, 3-a]pyrimidine is a newly identified antiviral agent against human immunodeficiency virus type 1 (HIV-1) infection, derived from 3, 4-dihydro-2H, 6H-pyrimido[1, 2-c][1, 3]benzothiazin-6-imine (PD 404182). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadaed17cc1c66be53e843fa5d950a43
https://pubmed.ncbi.nlm.nih.gov/25744188
https://pubmed.ncbi.nlm.nih.gov/25744188