Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Tsukasa Kadota"'
Autor:
Yu Fujita, Tsukasa Kadota, Reika Kaneko, Yuta Hirano, Shota Fujimoto, Naoaki Watanabe, Ryusuke Kizawa, Takashi Ohtsuka, Kazuyoshi Kuwano, Takahiro Ochiya, Jun Araya
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Acute lung injury (ALI) is characterized by respiratory failure resulting from the disruption of the epithelial and endothelial barriers as well as immune system. In this study, we evaluated the therapeutic potential of airway epithelial cel
Externí odkaz:
https://doaj.org/article/3f232368bcd5464db8bf088406cf5fc6
Autor:
Akihiko Ito, Mitsuo Hashimoto, Jun Tanihata, Sachi Matsubayashi, Ryoko Sasaki, Shota Fujimoto, Hironori Kawamoto, Yusuke Hosaka, Akihiro Ichikawa, Tsukasa Kadota, Yu Fujita, Daisuke Takekoshi, Sabro Ito, Shunsuke Minagawa, Takanori Numata, Hiromichi Hara, Tatsuki Matsuoka, Jun Udaka, Jun Araya, Mitsuru Saito, Kazuyoshi Kuwano
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 3, Pp 1864-1882 (2022)
Abstract Background Sarcopenia is characterized by the loss of skeletal muscle mass and strength and is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) exposure, a major cause for COP
Externí odkaz:
https://doaj.org/article/ad895a5d387e4cd6855dea08a616154a
Publikováno v:
European Respiratory Review, Vol 31, Iss 163 (2022)
The unperturbed lung is highly quiescent, with a remarkably low level of cell turnover. However, once damaged, the lung shows an extensive regenerative capacity, with resident progenitor cell populations re-entering the cell cycle and differentiating
Externí odkaz:
https://doaj.org/article/455a99dabb154f6fb53264c6e9a04e9f
Autor:
Tsukasa Kadota, Yu Fujita, Jun Araya, Naoaki Watanabe, Shota Fujimoto, Hironori Kawamoto, Shunsuke Minagawa, Hiromichi Hara, Takashi Ohtsuka, Yusuke Yamamoto, Kazuyoshi Kuwano, Takahiro Ochiya
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 10, Pp n/a-n/a (2021)
Abstract Idiopathic pulmonary fibrosis (IPF) is characterized by devastating and progressive lung parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of developmental lung gene expression, including genes for transfo
Externí odkaz:
https://doaj.org/article/6a88b2c6d3a3411688dd1af52c8a3412
Autor:
Yu Fujita, Tokio Hoshina, Juntaro Matsuzaki, Yusuke Yoshioka, Tsukasa Kadota, Yusuke Hosaka, Shota Fujimoto, Hironori Kawamoto, Naoaki Watanabe, Kenji Sawaki, Yohei Sakamoto, Makiko Miyajima, Kwangyole Lee, Kazuhiko Nakaharai, Tetsuya Horino, Ryo Nakagawa, Jun Araya, Mitsuru Miyato, Masaki Yoshida, Kazuyoshi Kuwano, Takahiro Ochiya
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 8, Pp n/a-n/a (2021)
Abstract The clinical manifestations of COVID‐19 vary broadly, ranging from asymptomatic infection to acute respiratory failure and death. But the predictive biomarkers for characterizing the variability are still lacking. Since emerging evidence i
Externí odkaz:
https://doaj.org/article/05acfe5b14d141c8969c51f964f32fdf
Autor:
Masahiro Yoshida, Shunsuke Minagawa, Jun Araya, Taro Sakamoto, Hiromichi Hara, Kazuya Tsubouchi, Yusuke Hosaka, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Nahoko Sato, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hirohumi Utsumi, Hiroshi Wakui, Takanori Numata, Yumi Kaneko, Shohei Mori, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Takeo Iwamoto, Hirotaka Imai, Kazuyoshi Kuwano
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Altered iron homeostasis resulting in excessive oxidative stress has been implicated in smoke-induced lung diseases. Here the authors show that ferroptosis of lung epithelial cells, potentially resulting from excessive ferritinophagy, is involved in
Externí odkaz:
https://doaj.org/article/7f973dabdbee4e05bfa82fda5c334da7
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2021)
Respiratory diseases and their comorbidities, such as cardiovascular disease and muscle atrophy, have been increasing in the world. Extracellular vesicles (EVs), which include exosomes and microvesicles, are released from almost all cell types and pl
Externí odkaz:
https://doaj.org/article/79e776369fe64ac09fb46677e0bf8c15
Autor:
Yusuke Kurita, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Kazuya Tsubouchi, Nahoko Sato, Masahiro Yoshida, Kenji Kobayashi, Saburo Ito, Yu Fujita, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Yutaka Yoshii, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Kazuyoshi Kuwano
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background Pirfenidone (PFD) is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis (IPF), but its precise mechanism of action remains elusive. Accumulation of profibrotic myofibroblasts is a crucial process for fibrotic remod
Externí odkaz:
https://doaj.org/article/1146926490a44a5c8c9022cb1d7ba748
Autor:
Yu Fujita, Jun Araya, Saburo Ito, Kenji Kobayashi, Nobuyoshi Kosaka, Yusuke Yoshioka, Tsukasa Kadota, Hiromichi Hara, Kazuyoshi Kuwano, Takahiro Ochiya
Publikováno v:
Journal of Extracellular Vesicles, Vol 4, Iss 0, Pp 1-12 (2015)
Extracellular vesicles (EVs), such as exosomes and microvesicles, encapsulate proteins and microRNAs (miRNAs) as new modulators of both intercellular crosstalk and disease pathogenesis. The composition of EVs is modified by various triggers to mainta
Externí odkaz:
https://doaj.org/article/5bd24b65c0ed4f6194fb91eb651b0ee8
Autor:
Naoaki Watanabe, Yu Fujita, Jun Nakayama, Yutaro Mori, Tsukasa Kadota, Yusuke Hayashi, Iwao Shimomura, Takashi Ohtsuka, Koji Okamoto, Jun Araya, Kazuyoshi Kuwano, Yusuke Yamamoto
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:708-719
Phenotypic alterations in the lung epithelium have been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, but the precise mechanisms orchestrating this persistent inflammatory process remain unknown because of the comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381ad3e03fda2142b45d906df44ad419
https://doi.org/10.1165/rcmb.2021-0555oc
https://doi.org/10.1165/rcmb.2021-0555oc