Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Tsukasa, Uno"'
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 54:677-685
BackgroundThis study developed a novel high-performance liquid chromatography (HPLC) method for the simultaneous quantification of clozapine and its active metabolite, N-desmethylclozapine, in human plasma and investigated the effects of various fact
Autor:
Ikumi Tamai, Ichiro Ieiri, Hisakazu Komori, Norio Yasui-Furukori, Masatomo Miura, Yumiko Akamine, Tsukasa Uno
Publikováno v:
Drug Metabolism and Pharmacokinetics. 30:352-357
The stereoselective pharmacokinetics of fexofenadine are associated with OATP2B1-mediated transport, and grapefruit juice (GFJ) is an inhibitor of OATP2B1. Therefore, in this study, we aimed to investigate whether and to what extent GFJ ingestion aff
Publikováno v:
Current drug metabolism. 20(2)
Background:Recent US Food and Drug Administration (FDA) draft guidance on pharmacokinetic drugdrug interactions (DDIs) has highlighted the clinical importance of ABC transporters B1 or P-glycoprotein (P-gp), hepatic organic anion-transporting polypep
Effects of selective serotonin reuptake inhibitors on the pharmacokinetics of proton pump inhibitors
Publikováno v:
Neuropsychiatry.
By now, the differential effects of several selective serotonin reuptake inhibitors (SSRIs) on the cytochrome P450 (CYP) enzymes are well defined and that the drug-drug interactions (DDIs) are a major issue in the management of depression. In many ca
Autor:
Masatomo Miura, Hiroyuki Kusuhara, Ikumi Tamai, Ichiro Ieiri, Yumiko Akamine, Norio Yasui-Furukori, Shun Saito, Hisakazu Komori, Tsukasa Uno
Publikováno v:
European Journal of Clinical Pharmacology. 70:1087-1095
We examined the effect of a single apple juice intake on the pharmacokinetics of fexofenadine enantiomers in healthy Japanese subjects.In a randomized two phase, open-label crossover study, 14 subjects received 60 mg of racemic fexofenadine simultane
Autor:
Yumiko Akamine, Tomonori Tateishi, Norio Yasui-Furukori, Satoshi Yamada, Hideo Shiohira, Tsukasa Uno
Publikováno v:
European Journal of Clinical Pharmacology. 69:1423-1428
Omeprazole has (R)- and (S)-enantiomers, which exhibit different pharmacokinetics (PK) among patients with cytochrome P450 (CYP) 2C19 genotype groups. The aim of this study was to investigate whether the 1-point, 4-h postdose (R)-omeprazole hydroxyla
Autor:
Satoshi Yamada, Tsukasa Uno
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 44:219-224
Autor:
Junji Saruwatari, Norio Yasui-Furukori, Yumiko Akamine, Sunao Kaneko, Tsukasa Uno, Takenori Niioka, Ayaka Takashima
Publikováno v:
Journal of Clinical Psychopharmacology. 32:195-199
Although the interaction between selective serotonin reuptake inhibitors (SSRIs) and other drugs is important in the treatment of depression, there have been few studies of SSRIs concerning transporter-mediated interactions in humans. The objective o
Publikováno v:
British Journal of Clinical Pharmacology. 73:478-481
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • We have shown that P-glycoprotein (P-gp) inhibitors such as itraconazole and verapamil significantly increase the plasma concentrations of fexofenadine enantiomers, and their effects are greater for (S)-fe
Publikováno v:
Clinical Neuropsychopharmacology and Therapeutics. 3:8-14