Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Tsugutaka, Ito"'
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 39:61-67
Effects of antihistamines, ebastine and terfenadine, on electrocardiogram in conscious dogs and cats
Autor:
Katsuyoshi Nakatsuji, Yoshihide Kii, Michiaki Matsuda, Masafumi Yabuuchi, Tsugutaka Ito, Isamu Nose
Publikováno v:
Drug Development Research. 58:209-217
The purpose of this study was to evaluate the effects of ebastine and terfenadine on the electrocardiogram of conscious dogs and cats. In dogs, terfenadine at oral doses of 30 mg/kg twice a day for 7 days prolonged the electrocardiographic QT interva
Effects of Mosapride Citrate, a 5-HT4 Receptor Agonist, on Colonic Motility in Conscious Guinea Pigs
Publikováno v:
Japanese Journal of Pharmacology. 90:313-320
It is known that 5-HT(4) receptors in the colon of guinea pigs show a distribution similar to that in humans. Thus, we examined the effects of mosapride citrate (mosapride) and cisapride, two 5-HT(4)-receptor agonists, on colonic motility in consciou
Publikováno v:
Pharmacology and Toxicology. 89:171-176
The present study was performed to compare the properties of ebastine--the long duration of antiallergic effect and less penetration to the CNS--with those of other H1-antihistamines. Passive cutaneous anaphylactic reaction was induced and the dye le
Publikováno v:
Neuroscience Letters. 234:115-118
Kindling model is useful to study the mechanism of learning and memory. Cholecystokinin (CCK) mRNA and CCK-like immunoreactivity (CCK-LI) levels in the hippocampus and frontal cortex of chemically kindled rats were determined at different time points
Autor:
Yoshihide Kii, Tsugutaka Ito
Publikováno v:
Journal of Cardiovascular Pharmacology. 29:670-675
The purpose of this study was to examine the effects of 5-HT4-receptor agonists cisapride, mosapride citrate (mosapride), and zacopride on action potentials (APs) in guinea pig isolated papillary muscles. Cisapride (0.1-3 microM) concentration-relate
Publikováno v:
YAKUGAKU ZASSHI. 116:533-547
Zonisamide (1,2-benzisoxazole-3-methanesulfonamide, AD-810) is a broad spectrum antiepileptic drug which has been launched in Japan and South Korea. It lacks the ureide structure included in most of the existing antiepileptic drugs. Zonisamide was sy
Publikováno v:
ChemInform. 28
Zonisamide (1,2-benzisoxazole-3-methanesulfonamide, AD-810) is a broad spectrum antiepileptic drug which has been launched in Japan and South Korea. It lacks the ureide structure included in most of the existing antiepileptic drugs. Zonisamide was sy
Autor:
Yoshihide, Kii, Tsugutaka, Ito
Publikováno v:
Pharmacologytoxicology. 90(5)
The aims of this study were to develop a suitable model to study proarrhythmic potential using isolated rabbit hearts with atrioventricular block and to examine the proarrhythmic potential of several drugs using this model. With a normal K/Mg solutio
Autor:
Masafumi Yabuuchi, Isamu Nose, Tsugutaka Ito, Yasuyuki Mizuki, Katsuyoshi Nakatsuji, Yoshihide Kii
Publikováno v:
Pharmacologytoxicology. 89(2)
The purpose of this study was to examine the arrhythmogenic potential of 5-HT4 receptor agonists, cisapride and mosapride citrate (mosapride) in vivo. In anaesthetized rats, cisapride at intravenous infusion of 10 and 30 mg/kg/hr for 1 hr prolonged t