Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tsuguo Ikebe"'
Autor:
Takeshi Kawakita, Shuji Sonda, Koji Kanzaki, Keiichiro Haga, Takanobu Kuroita, Katsuhiko Itoh, Noriko Sato, Hideo Tomozane, Tsuguo Ikebe
Publikováno v:
European Journal of Medicinal Chemistry. 34:977-989
A number of new carboxamide derivatives were synthesized. The affinity of these compounds for the serotoninergic 5-HT(4) receptor was evaluated by use of radioligand-binding techniques. The agonistic activity was evaluated as the contractile effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d6b155b250cb35ff1c20be761036b3
https://doi.org/10.1016/s0223-5234(99)00158-0
https://doi.org/10.1016/s0223-5234(99)00158-0
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1245-1250
(R)-N-(1-Benzyl-2-pyrrolidinylmethyl)-6-methylthio-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide exhibited high affinities for all of D2, 5-HT1 A, and 5-HT2 receptors (Ki=0.0042 μM, Ki=0.017 μM, and Ki=0.027 μM, respectively).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa09c1553af8fb11a55c6708318fc93c
https://doi.org/10.1016/0960-894x(95)00197-2
https://doi.org/10.1016/0960-894x(95)00197-2
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d48af62dadb3536244f584e935df7e9f
https://doi.org/10.1002/chin.199242159
https://doi.org/10.1002/chin.199242159
Autor:
Atsushi Fukunari, Takanori Oe, Yoichi Naka, Seigo Ishibuchi, Tsuguo Ikebe, Hiroshi Morimoto, Ichimaro Yamada, Miho Kamezawa, Hiroyoshi Inoue
Publikováno v:
ChemInform. 32
A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78fdbfd650314b9307c626149025262b
https://doi.org/10.1002/chin.200150107
https://doi.org/10.1002/chin.200150107
Autor:
Hiroshi Morimoto, Tsuguo Ikebe, Atsushi Fukunari, Yoichi Naka, Takanori Oe, Ichimaro Yamada, Seigo Ishibuchi, Hiroyoshi Inoue, Miho Kamezawa
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(7)
A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7106faab40971656ad68c7636cf3101a
https://pubmed.ncbi.nlm.nih.gov/11294382
https://pubmed.ncbi.nlm.nih.gov/11294382
N-((1-long alkyl-2-pyrrolidinyl) methyl) benzamides with potent serotonin 5-HT1A receptor affinities
Publikováno v:
Chemical and Pharmaceutical Bulletin. 39:3370-3372
A series of N-(2-pyrrolidinylmethyl)-2-methoxy-5-sulfamoylbenzamide derivatives bearing a long alkyl chain at the 1-position of the pyrrolidine ring was synthesized and found to possess high affinities for serotonin 5-HT1A receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdaaa704d86dc013698635f93f31402
https://doi.org/10.1248/cpb.39.3370
https://doi.org/10.1248/cpb.39.3370