Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tsuguka Kouno"'
Autor:
Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata, Daisuke Yasuda, Kyoko Takahashi, Tsutomu Fujimura, Jingbo Pi, Myung-Shik Lee, Takashi Ueno, Tomoyuki Ohe, Tadahiko Mashino, Toshifumi Wakai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hozumi Motohashi, Satoshi Waguri, Tomoyoshi Soga, Masayuki Yamamoto, Keiji Tanaka, Masaaki Komatsu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Dysregulation of p62 has been implicated in tumorigenesis. Here, the authors show that p62 promotes hepatocellular carcinoma by reprogramming glucose and glutamine metabolism through Nrf2 and present a novel compound that can inhibit p62 action thus
Externí odkaz:
https://doaj.org/article/f562794e07c0466a84d8f58624fb3b55
Autor:
Kyoko Takahashi, Miki Obata, Takefumi Uemura, Tsuguka Kouno, Masayuki Nagahashi, Shujiro Okuda, Tetsuya Saito, Takafumi Suzuki, Tomoyuki Ohe, Tadahiko Mashino, Satoshi Waguri, Yukio Tada, Jingbo Pi, Kenji Takagi, Maki Ohishi, Yuki Hirose, Masayuki Yamamoto, Toshifumi Wakai, Takayoshi Okabe, Rika Obata, Hozumi Motohashi, Myung-Shik Lee, Tetsuro Iso, Daisuke Yasuda, Takashi Ueno, Tsutomu Fujimura, Yasumasa Nishito, Tsunehiro Mizushima, Keiko Taguchi, Keiji Tanaka, Tetsuo Nagano, Yoshinobu Ichimura, Tomoyoshi Soga, Keiko Endo, Riyo Imamura, Toshiaki Fukutomi, Masaaki Komatsu, Hirotatsu Kojima
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that is degraded by autophagy. Amplification of the p62/Sqstm1 gene, and aberrant accumulation and phosphorylation of p62/Sqstm1, have been implicated in tumour deve
Autor:
Masayuki Yamamoto, Shun Kageyama, Lynn Bedford, R. John Mayer, Keiji Tanaka, Satoshi Kametaka, Tetsuya Saito, Tsuguka Kouno, Satoshi Waguri, Masaaki Komatsu, Takefumi Uemura, Ryosuke Ishimura, Myung-Shik Lee, Yu-shin Sou
The ubiquitin-proteasome system and autophagy are crucially important for proteostasis in cells. These pathways are interdependent, and dysfunction in either pathway causes accumulation of ubiquitin-positive aggregates, a hallmark of human pathologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd60bf3ce54f288767d5724de636de6
https://europepmc.org/articles/PMC4155663/
https://europepmc.org/articles/PMC4155663/
Autor:
Yu-shin Sou, Takayuki Hoshii, Yoshinobu Ichimura, Myung-Shik Lee, Tsuguka Kouno, Tamotsu Yoshimori, Masaaki Komatsu, Jun Hasegawa, Tetsuya Saito, Masayuki Yamamoto, Satoshi Waguri, Yinjie Yang, Shun Kageyama, Toshiaki Fukutomi, Kenji Takagi, Tsunehiro Mizushima, Keiji Tanaka, Ryosuke Ishimura, Hozumi Motohashi, Atsushi Hirao
Publikováno v:
Molecular cell. 51(5)
Summary The Keap1-Nrf2 system and autophagy are both involved in the oxidative-stress response, metabolic pathways, and innate immunity, and dysregulation of these processes is associated with pathogenic processes. However, the interplay between thes
Autor:
Masaaki Komatsu, Tsuguka Kouno, Sumio Watanabe, Ayako N. Sakamoto, Yoshihiro Inami, Okio Hino, Manabu Iwadate, Jin Ando, Satoshi Waguri, Myung-Shik Lee, Kazuto Nakada, Keiji Tanaka, Masayuki Yamamoto
Publikováno v:
The Journal of Cell Biology
Impaired autophagy stabilizes p62 and promotes tumorigenesis through activation of the Nrf2 transcription factor.
Suppression of autophagy is always accompanied by marked accumulation of p62, a selective autophagy substrate. Because p62 interact
Suppression of autophagy is always accompanied by marked accumulation of p62, a selective autophagy substrate. Because p62 interact
Autor:
Shun Kageyama1,2, Yu-shin Sou2, Takefumi Uemura3, Satoshi Kametaka3, Tetsuya Saito1,4, Ryosuke Ishimura1,4, Tsuguka Kouno2, Lynn Bedford5, John Mayer, R.5, Myung-Shik Lee6, Masayuki Yamamoto7, Waguri, Satoshi3, Keiji Tanaka4, Masaaki Komatsu1,2 komatsu-ms@med.niigata-u.ac.jp
Publikováno v:
Journal of Biological Chemistry. 9/5/2014, Vol. 289 Issue 36, p24944-24955. 12p.