βPS-Integrin acts downstream of Innexin 2 in modulating stretched cell morphogenesis in the Drosophila ovary

Autor: Yi-Chia Huang, Kuan-Han Chen, Yu-Yang Chen, Liang-Hsuan Tsao, Tsung‐Han Yeh, Yu-Chia Chen, Ping-Yen Wu, Tsu-Wei Wang, Jenn-Yah Yu

Publikováno v: G3: Genes, Genomes, Genetics, Vol 11, Iss 9 (2021)

AbstractDuring oogenesis, a group of specialized follicle cells, known as stretched cells (StCs), flatten drastically from cuboidal to squamous shape. While morphogenesis of epithelia is critical for organogenesis, genes and signaling pathways involv

Externí odkaz: https://doaj.org/article/f85e4c64cc65484a9f4a4285736bdeae

The Hippo pathway acts downstream of the Hedgehog signaling to regulate follicle stem cell maintenance in the Drosophila ovary

Autor: Ta-Hsing Hsu, Chia-Yu Yang, Tsung-Han Yeh, Yi-Chia Huang, Tsu-Wei Wang, Jenn-Yah Yu

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract The Hippo pathway is conserved and plays important roles in organ size control. The core components of the Hippo pathway are two kinases Hippo (Hpo), Warts (Wts), and a transcription-co-activator Yorkie (Yki). Yki activity is regulated by ph

Externí odkaz: https://doaj.org/article/50deaebf4e6b45aeb7d648fe64ee7dbb

Neonatal hypoxic–ischemic injury increases forebrain subventricular zone neurogenesis in the mouse

Autor: Jennifer M Plane, Ruowen Liu, Tsu-Wei Wang, Faye S Silverstein, Jack M Parent

Publikováno v: Neurobiology of Disease, Vol 16, Iss 3, Pp 585-595 (2004)

Neurogenesis persists throughout life in the rodent subventricular zone (SVZ)–olfactory bulb pathway and increases in the adult after brain insults. The influence of neonatal injury on SVZ neural precursors is unknown. We examined the effects of hy

Externí odkaz: https://doaj.org/article/665f58287ba3436f829cd48a36d48740

Lithium for schizophrenia: supporting evidence from a 12-year, nationwide health insurance database and from Akt1-deficient mouse and cellular models

Autor: Wen-Sung Lai, Chia-Yuan Chang, Tsung-Ren Huang, Tsu Wei Wang, Da Zhong Luo, Vincent Studer

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-019-57340-8⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Accumulating evidence suggests AKT1 and DRD2-AKT-GSK3 signaling involvement in schizophrenia. AKT1 activity is also required for lithium, a GSK3 inhibitor, to modulate mood-related behaviors. Notably, GSK3 inhibitor significantly alleviates behaviora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d8646749d580cf067ae698f36beec2
https://hal.archives-ouvertes.fr/hal-03096957

Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon

Autor: Tsu Wei Wang, Yuchio Yanagawa, Pei-Lin Cheng, Jin Wu Tsai, Wan Shan Yang, Yuan Hsuan Liu, Jenn Yah Yu, Jia Long Chen, Pei Ching Chang, David L. Turner

Publikováno v: Scientific Reports

During development, cortical interneurons generated from the ventral telencephalon migrate tangentially into the dorsal telencephalon. Although Achaete-scute family bHLH transcription factor 1 (Ascl1) plays important roles in the developing telenceph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dd2a5901c89945c853ad9aa5bf6f5f