Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Tsu Tshen Chuang"'
Autor:
Anna C. Liang, Emiri T. Mandeville, Takakuni Maki, Akihiro Shindo, Angel T. Som, Naohiro Egawa, Kanako Itoh, Tsu Tshen Chuang, John D. Mcneish, Julie C. Holder, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Aging and vascular comorbidities such as hypertension comprise critical cofactors that influence how the brain responds to stroke. Ischemic stress induces neurogenesis and oligodendrogenesis in younger brains. However, it remains unclear whether thes
Externí odkaz:
https://doaj.org/article/7f922247b54b4e03869f0a5b1867d9c6
Autor:
Seong-Ho Koh, Anna C Liang, Yoko Takahashi, Takakuni Maki, Akihiro Shindo, Noriko Osumi, Jing Zhao, Hong Lin, Julie C Holder, Tsu Tshen Chuang, John D McNeish, Ken Arai, Eng H Lo
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138724 (2015)
Adult mammalian brain can be plastic after injury and disease. Therefore, boosting endogenous repair mechanisms would be a useful therapeutic approach for neurological disorders. Isoxazole-9 (Isx-9) has been reported to enhance neurogenesis from neur
Externí odkaz:
https://doaj.org/article/b9dd175d20b44bf8ae6c1950c4205930
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16991 (2011)
Impaired insulin signalling is increasingly thought to contribute to Alzheimer's disease (AD). The ε4 isoform of the APOE gene is the greatest genetic risk factor for sporadic, late onset AD, and is also associated with risk for type 2 diabetes mell
Externí odkaz:
https://doaj.org/article/f07aeb8cb7d248069530e26bba939a50
Autor:
Veronique Beneton, Veena Supramaniam, Bobbi Fleiss, Juliette Van Steenwinckel, Ana A. Baburamani, Carina Mallard, Leslie Schwendimann, Jingjun Li, Nathalie Journiac, Pierrette Young-Ten, Boris Matrot, Pierre Gressens, Johanna Maze, A. David Edwards, Claire-Marie Rangon, Sophie Lebon, Henrik Hagberg, Libo Chen, Tingting Fu, Thomas Bourgeois, Tsu Tshen Chuang, Lionel Trottet, Anne-Laure Schang
Publikováno v:
Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, 2018, 74, pp.265-276. ⟨10.1016/j.bbi.2018.09.017⟩
Brain, Behavior, and Immunity, Elsevier, 2018, 74, pp.265-276. ⟨10.1016/j.bbi.2018.09.017⟩
Rangon, C-M, Schang, A-L, Van Steenwinckel, J, Schwendimann, L, Lebon, S, Fu, T, Chen, L, Beneton, V, Journiac, N, Young-Ten, P, Bourgeois, T, Maze, J, Matrot, B, Baburamani, A A, Supramaniam, V, Mallard, C, Trottet, L, Edwards, A D, Hagberg, H, Fleiss, B, Li, J, Tshen Chuang, T & Gressens, P 2018, ' Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury ', Brain, Behavior, and Immunity . https://doi.org/10.1016/j.bbi.2018.09.017
Brain, Behavior, and Immunity, 2018, 74, pp.265-276. ⟨10.1016/j.bbi.2018.09.017⟩
Brain, Behavior, and Immunity, Elsevier, 2018, 74, pp.265-276. ⟨10.1016/j.bbi.2018.09.017⟩
Rangon, C-M, Schang, A-L, Van Steenwinckel, J, Schwendimann, L, Lebon, S, Fu, T, Chen, L, Beneton, V, Journiac, N, Young-Ten, P, Bourgeois, T, Maze, J, Matrot, B, Baburamani, A A, Supramaniam, V, Mallard, C, Trottet, L, Edwards, A D, Hagberg, H, Fleiss, B, Li, J, Tshen Chuang, T & Gressens, P 2018, ' Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury ', Brain, Behavior, and Immunity . https://doi.org/10.1016/j.bbi.2018.09.017
Fifteen million babies are born preterm every year and a significant number suffer from permanent neurological injuries linked to white matter injury (WMI). A chief cause of preterm birth itself and predictor of the severity of WMI is exposure to mat
Autor:
Tsu Tshen Chuang
Publikováno v:
Regenerative medicine. 11(5)
Autor:
Takakuni Maki, John D. McNeish, Josephine Lok, Eng H. Lo, Ken Arai, Tsu Tshen Chuang, Akihiro Shindo, Kanako Itoh, Angel T. Som, Anna C. Liang, Julie C. Holder, Naohiro Egawa, Emiri T. Mandeville
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Aging and vascular comorbidities such as hypertension comprise critical cofactors that influence how the brain responds to stroke. Ischemic stress induces neurogenesis and oligodendrogenesis in younger brains. However, it remains unclear whether thes
Autor:
John D. McNeish, Kanako Itoh, Josephine Lok, Julie C. Holder, Anna C. Liang, Takakuni Maki, Akihiro Shindo, Mia C Borlongan, Emiri T. Mandeville, Hidekazu Tomimoto, Naohiro Egawa, Eng H. Lo, Ken Arai, Naoki Itoh, Tsu Tshen Chuang
Publikováno v:
Stroke. 47(4)
Background and Purpose— Pentraxin 3 (PTX3) is released on inflammatory responses in many organs. However, roles of PTX3 in brain are still mostly unknown. Here we asked whether and how PTX3 contributes to blood–brain barrier dysfunction during th
Autor:
Aurelie C. Champigny, Benjamin D. Bax, James R. Musgrave, Emma J. Jones, Murray J. B. Brown, J. Mosley, John A. Christopher, Francis Louis Atkinson, Tsu Tshen Chuang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2230-2234
A series of 1-aryl-3,4-dihydroisoquinoline inhibitors of JNK3 are described. Compounds 20 and 24 are the most potent inhibitors (pIC50 7.3 and 6.9, respectively in a radiometric filter binding assay), with 10- and 1000-fold selectivity over JNK2 and
Publikováno v:
Journal of Neurochemistry. 107:964-975
The proliferation and differentiation of neural progenitor (NP) cells can be regulated by neurotransmitters including GABA and dopamine. The present study aimed to examine how these two neurotransmitter systems interact to affect post-natal hippocamp
Autor:
Jie Luo, Emiri T. Mandeville, Hong Lin, Eng H. Lo, Xuedong Dai, Dan Pu, Ken Arai, Jing Zhao, Qinghua Meng, Julie C. Holder, Libo Chen, Tsu Tshen Chuang, Douglas Minick, Jamie Wang, Haiyan Fang, Sharon Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(17)
A novel neurogenic compound (1), discovered from a mouse neural progenitor cell (NPC) screen, showed profound neurogenic effect on human NPCs. Synthesis and SAR of this novel 2,3,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinoline-1,4(6H)-dione series a