New susceptibility alleles associated with severe coronary artery stenosis in the Lebanese population

Autor: Victor Wakim, Elie Abi Khalil, Angelique K. Salloum, Georges Khazen, Michella Ghassibe-Sabbagh, Pierre A. Zalloua

Publikováno v: BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)

Abstract Background Coronary Artery Disease (CAD) is the narrowing or blockage of the coronary arteries. It is closely associated with numerous genetics and environmental factors that have been extensively evaluated in various populations. In recent

Externí odkaz: https://doaj.org/article/fded511834324feb90c9437dcf5dfa4b

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

DNA Methylation and Gene Expression in Blood and Adipose Tissue of Adult Offspring of Women with Diabetes in Pregnancy—A Validation Study of DNA Methylation Changes Identified in Adolescent Offspring

Autor: Eleonora Manitta, Irene Carolina Fontes Marques, Sandra Stokholm Bredgaard, Louise Kelstrup, Azadeh Houshmand-Oeregaard, Tine Dalsgaard Clausen, Louise Groth Grunnet, Elisabeth Reinhardt Mathiesen, Louise Torp Dalgaard, Romain Barrès, Allan Arthur Vaag, Peter Damm, Line Hjort

Publikováno v: Manitta, E, Marques, I C F, Bredgaard, S S, Kelstrup, L, Houshmand-Oeregaard, A, Clausen, T D, Grunnet, L G, Mathiesen, E R, Dalgaard, L T, Barrès, R, Vaag, A A, Damm, P & Hjort, L 2022, ' DNA Methylation and Gene Expression in Blood and Adipose Tissue of Adult Offspring of Women with Diabetes in Pregnancy-A Validation Study of DNA Methylation Changes Identified in Adolescent Offspring ', Biomedicines, vol. 10, no. 6, 1244 . https://doi.org/10.3390/biomedicines10061244
Biomedicines; Volume 10; Issue 6; Pages: 1244

Maternal gestational diabetes and obesity are associated with adverse outcomes in offspring, including increased risk of diabetes and cardiovascular diseases. Previously, we identified a lower DNA methylation degree at genomic sites near the genes ES

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3387752bac3f40c79b914ea182702ba9
https://doi.org/10.3390/biomedicines10061244

New susceptibility alleles associated with severe coronary artery stenosis in the Lebanese population

Autor: Georges Khazen, Pierre Zalloua, Angelique K. Salloum, Elie Abi Khalil, Michella Ghassibe-Sabbagh, Victor Wakim

Publikováno v: BMC Medical Genomics
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)

Background Coronary Artery Disease (CAD) is the narrowing or blockage of the coronary arteries. It is closely associated with numerous genetics and environmental factors that have been extensively evaluated in various populations. In recent studies,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e56fb18be3071e49683febfce4e566
https://pubmed.ncbi.nlm.nih.gov/33766035

The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

Autor: Edward T Davis, Michael G. Tomlinson, Lisa Seipold, Murat Keles, Natalie S. Poulter, Paul Saftig, Antonia Malinova, Stephan A. Mueller, Stefan F. Lichtenthaler, Alexandra L. Matthews, Bethany Cragoe, Hanh T.H. Nguyen, Stephen J. Briddon, Nicholas D. Holliday, Christos Pliotas, Chek Ziu Koo, Eric Rubinstein, Thomas A. McFarlane, Johanna Tüshaus, Michael C. Sykes, Justyna Szyroka, Eleanor Cull, Katie Willis, Haroon Ahmed, Alessandro Di Maio, Clara Apicella, Joelle Goulding, Peter J. Noy, Neale Harrison, Hung-En Hsia, Philip R. Morrison

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
The journal of biological chemistry 295(36), 12822-12839 (2020). doi:10.1074/jbc.RA120.012601
J Biol Chem
Journal of Biological Chemistry, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
Koo, C Z, Harrison, N, Noy, P J, Szyroka, J, Matthews, A L, Hsia, H-E, Müller, S A, Tüshaus, J, Goulding, J, Willis, K, Apicella, C, Cragoe, B, Davis, E, Keles, M, Malinova, A, McFarlane, T A, Morrison, P R, Nguyen, H T H, Sykes, M C, Ahmed, H, Maio, A D, Seipold, L, Saftig, P, Cull, E, Pliotas, C, Rubinstein, E, Poulter, N S, Briddon, S J, Holliday, N D, Lichtenthaler, S F & Tomlinson, M G 2020, ' The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12822-12839 . https://doi.org/10.1074/jbc.RA120.012601

International audience; A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein essential for embryonic development, and its dysregulation underlies disorders such as cancer, Alzheimer's disease, and inflammation. ADAM10 is a “mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8eb363ab27157e6e501561ef205a029
https://hal.sorbonne-universite.fr/hal-03124330