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SARS-CoV-2 Orphan Gene ORF10 Contributes to More Severe COVID-19 Disease.

Autor: Haltom J; Department of Genetics Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA., Trovao NS; Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, 20892, USA.; COVID-19 International Research Team, Medford, MA 02155, USA., Guarnieri J; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA., Vincent P; Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, 20892, USA., Singh U; Bioinformatics and Computational Biology Program, and Genetics Program, Iowa State University, Ames, IA 50011, USA., Tsoy S; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., O'Leary CA; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Bram Y; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Widjaja GA; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Cen Z; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Meller R; Morehouse School of Medicine, Atlanta, GA , 30310-1495, USA., Baylin SB; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231.; Van Andel Research Institute, Grand Rapids, MI 49503., Moss WN; Bioinformatics and Computational Biology Program, and Genetics Program, Iowa State University, Ames, IA 50011, USA.; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Nikolau BJ; Bioinformatics and Computational Biology Program, and Genetics Program, Iowa State University, Ames, IA 50011, USA.; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA., Enguita FJ; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal., Wallace DC; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA., Beheshti A; COVID-19 International Research Team, Medford, MA 02155, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Blue Marble Space Institute of Science, Seattle, WA, 98104 USA., Schwartz R; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA.; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA., Wurtele ES; Bioinformatics and Computational Biology Program, and Genetics Program, Iowa State University, Ames, IA 50011, USA.; Department of Genetics Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.; COVID-19 International Research Team, Medford, MA 02155, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Nov 27. Date of Electronic Publication: 2023 Nov 27.