Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides.

Autor: Tone Y; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.; Discovery Research Laboratories in Tsukuba, Nippon Shinyaku Co., Ltd., Tsukuba, Japan., Mamchaoui K; Center of Research in Myology, Sorbonne University, INSERM, Institute of Myology, Paris, France., Tsoumpra MK; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Hashimoto Y; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Terada R; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Maruyama R; Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Gait MJ; Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Arzumanov AA; Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom.; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., McClorey G; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Imamura M; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Takeda S; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan., Yokota T; Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Wood MJA; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Oxford Harrington Rare Disease Centre, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom., Mouly V; Center of Research in Myology, Sorbonne University, INSERM, Institute of Myology, Paris, France., Aoki Y; Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.

Publikováno v: Nucleic acid therapeutics [Nucleic Acid Ther] 2021 Apr; Vol. 31 (2), pp. 172-181. Date of Electronic Publication: 2021 Feb 09.

How do we sense phosphate to regulate serum phosphate level?

Autor: Fukumoto S; Department of Molecular Endocrinology, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan. fukumoto-tky@umin.ac.jp., Takashi Y; Department of Molecular Endocrinology, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.; Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyoin, Chikushino, 818-8502, Japan., Tsoumpra MK; Department of Molecular Endocrinology, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.; Department of Molecular Therapy, National Institute of Neuroscience, National Center for Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo, 187-8502, Japan., Sawatsubashi S; Department of Molecular Endocrinology, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan., Matsumoto T; Department of Molecular Endocrinology, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.

Publikováno v: Journal of bone and mineral metabolism [J Bone Miner Metab] 2020 Jan; Vol. 38 (1), pp. 1-6. Date of Electronic Publication: 2019 Dec 03.

Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation.

Autor: Takashi Y; Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 7708503 Tokushima, Japan.; Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 7708503 Tokushima, Japan.; Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo-ku, 1138655 Tokyo, Japan.; Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 7708503 Tokushima, Japan., Kosako H; Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 7708503 Tokushima, Japan., Sawatsubashi S; Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 7708503 Tokushima, Japan., Kinoshita Y; Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo-ku, 1138655 Tokyo, Japan., Ito N; Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo-ku, 1138655 Tokyo, Japan., Tsoumpra MK; Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 7708503 Tokushima, Japan., Nangaku M; Division of Nephrology and Endocrinology, The University of Tokyo Hospital, Bunkyo-ku, 1138655 Tokyo, Japan., Abe M; Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 7708503 Tokushima, Japan., Matsuhisa M; Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 7708503 Tokushima, Japan., Kato S; Graduate School of Science and Engineering, Iryo Sosei University, Iwaki, 9708551 Fukushima, Japan.; Research Institute of Innovative Medicine, Tokiwa Foundation, Iwaki, 9728322 Fukushima, Japan., Matsumoto T; Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 7708503 Tokushima, Japan., Fukumoto S; Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 7708503 Tokushima, Japan; fukumoto-tky@umin.ac.jp.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jun 04; Vol. 116 (23), pp. 11418-11427. Date of Electronic Publication: 2019 May 16.

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

Autor: Lawson MA; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Ebetino FH; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK.; Department of Chemistry, University of Rochester, Rochester, NY, USA., Mazur A; TWI Chem LLC, Mason, OH, USA., Chantry AD; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Paton-Hough J; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Evans HR; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Lath D; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Tsoumpra MK; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK., Lundy MW; Department of Anatomy and Cell Biology, Indiana University, Indianapolis, IN, USA., Dobson RL; Procter & Gamble, Mason, OH, USA., Quijano M; Procter & Gamble, Mason, OH, USA., Kwaasi AA; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Dunford JE; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Duan X; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Triffitt JT; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK., Jeans G; Procter & Gamble, Mason, OH, USA., Russell RGG; Department of Oncology and Metabolism, Medical School, University of Sheffield, UK.; Mellanby Centre for Bone Research, Medical School, University of Sheffield, UK.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Oxford University Institute of Musculoskeletal Sciences, The Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK.

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2017 Sep; Vol. 32 (9), pp. 1860-1869. Date of Electronic Publication: 2017 Apr 21.