Progressive degeneration in a new Drosophila model of spinocerebellar ataxia type 7.

Autor: Sujkowski A; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall Rm 3108, Detroit, MI, 48201, USA., Ranxhi B; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall Rm 3108, Detroit, MI, 48201, USA., Bangash ZR; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall Rm 3108, Detroit, MI, 48201, USA., Chbihi ZM; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall Rm 3108, Detroit, MI, 48201, USA., Prifti MV; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall Rm 3108, Detroit, MI, 48201, USA., Qadri Z; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall Rm 3108, Detroit, MI, 48201, USA., Alam N; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall Rm 3108, Detroit, MI, 48201, USA., Todi SV; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall Rm 3108, Detroit, MI, 48201, USA.; Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA., Tsou WL; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Scott Hall Rm 3108, Detroit, MI, 48201, USA. wtsou@wayne.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Jun 21; Vol. 14 (1), pp. 14332. Date of Electronic Publication: 2024 Jun 21.

Lysine 117 on ataxin-3 modulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.

Autor: Blount JR; Department of Pharmacology, Wayne State University, United States of America., Patel NC; Department of Pharmacology, Wayne State University, United States of America., Libohova K; Department of Pharmacology, Wayne State University, United States of America., Harris AL; Department of Pharmacology, Wayne State University, United States of America; Maximizing Access to Research Careers, Wayne State University, United States of America., Tsou WL; Department of Pharmacology, Wayne State University, United States of America., Sujkowski A; Department of Pharmacology, Wayne State University, United States of America. Electronic address: asujkows@med.wayne.edu., Todi SV; Department of Pharmacology, Wayne State University, United States of America; Maximizing Access to Research Careers, Wayne State University, United States of America; Department of Neurology, Wayne State University, United States of America. Electronic address: stodi@wayne.edu.

Publikováno v: Journal of the neurological sciences [J Neurol Sci] 2023 Nov 15; Vol. 454, pp. 120828. Date of Electronic Publication: 2023 Oct 05.

A survey of protein interactions and posttranslational modifications that influence the polyglutamine diseases.

Autor: Johnson SL; Department of Pharmacology, Wayne State University, Detroit, MI, United States., Tsou WL; Department of Pharmacology, Wayne State University, Detroit, MI, United States., Prifti MV; Department of Pharmacology, Wayne State University, Detroit, MI, United States., Harris AL; Department of Pharmacology, Wayne State University, Detroit, MI, United States.; Maximizing Access to Research Careers (MARC) Program, Wayne State University, Detroit, MI, United States., Todi SV; Department of Pharmacology, Wayne State University, Detroit, MI, United States.; Maximizing Access to Research Careers (MARC) Program, Wayne State University, Detroit, MI, United States.; Department of Neurology, Wayne State University, Detroit, MI, United States.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2022 Sep 14; Vol. 15, pp. 974167. Date of Electronic Publication: 2022 Sep 14 (Print Publication: 2022).

Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3.

Autor: Johnson SL; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Libohova K; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Blount JR; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Sujkowski AL; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA; Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Prifti MV; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Tsou WL; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA., Todi SV; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA; Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA. Electronic address: stodi@wayne.edu.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2021 Dec; Vol. 160, pp. 105516. Date of Electronic Publication: 2021 Sep 24.

ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans (C. elegans).

Autor: Ladagu, Amany¹ (AUTHOR), Olopade, Funmilayo² (AUTHOR), Chazot, Paul³ (AUTHOR), Elufioye, Taiwo⁴ (AUTHOR), Luong, Toan⁵ (AUTHOR), Fuller, Madison⁵ (AUTHOR), Halprin, Ethan⁶ (AUTHOR), Mckay, Jessica⁶ (AUTHOR), Ates-Alagoz, Zeynep⁷ (AUTHOR), Gilbert, Taidinda¹ (AUTHOR), Adejare, Adeboye⁶ (AUTHOR) aadejare@sju.edu, Olopade, James¹ (AUTHOR)

Publikováno v: BMC Neuroscience. 10/28/2024, Vol. 25 Issue 1, p1-20. 20p.