Dissecting heterogeneous cell populations across drug and disease conditions with PopAlign

Autor: Chen, Sisi, Rivaud, Paul, Park, Jong H., Tsou, Tiffany, Charles, Emeric, Haliburton, John R., Pichiorri, Flavia, Thomson, Matt

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2020 Nov . 117(46), 28784-28794.

Externí odkaz: https://www.jstor.org/stable/26971001

D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response

Autor: Jiang, Jialong, Chen, Sisi, Tsou, Tiffany, McGinnis, Christopher S., Khazaei, Tahmineh, Zhu, Qin, Park, Jong H., Strazhnik, Inna-Marie, Hanna, John, Chow, Eric D., Sivak, David A., Gartner, Zev J., Thomson, Matt

Publikováno v: bioRxiv

Gene regulatory networks within cells modulate the expression of the genome in response to signals and changing environmental conditions. Reconstructions of gene regulatory networks can reveal the information processing and control principles used by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a49777e4b31ab068e97d3ea14712d9
https://doi.org/10.1101/2023.04.19.537364

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D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response.

Autor: Jiang J; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125, USA., Chen S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125, USA.; Beckman Single-Cell Profiling and Engineering Center, California Institute of Technology, Pasadena, CA, 91125, USA.; Apertura Gene Therapy, 345 Park Ave South, New York, NY 10010., Tsou T; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125, USA.; Beckman Single-Cell Profiling and Engineering Center, California Institute of Technology, Pasadena, CA, 91125, USA., McGinnis CS; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94143, USA., Khazaei T; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125, USA., Zhu Q; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94143, USA., Park JH; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125, USA.; Beckman Single-Cell Profiling and Engineering Center, California Institute of Technology, Pasadena, CA, 91125, USA., Strazhnik IM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125, USA., Vielmetter J; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125, USA., Gong Y; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125, USA., Hanna J; Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, 02115, USA., Chow ED; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, 94143, USA.; Center for Advanced Technology, University of California San Francisco, San Francisco, CA, 94143, USA., Sivak DA; Department of Physics, Simon Fraser University, Burnaby, BC V5A 1S6, Canada., Gartner ZJ; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94143, USA.; Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94115, USA.; Chan Zuckerberg BioHub, University of California San Francisco, San Francisco, CA, 94143, USA.; Center for Cellular Construction, University of California San Francisco, San Francisco, CA, 94143, USA., Thomson M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125, USA.; Beckman Single-Cell Profiling and Engineering Center, California Institute of Technology, Pasadena, CA, 91125, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 04. Date of Electronic Publication: 2024 Jun 04.