Výsledky vyhledávání - "Tsong H. Chang"

Quantitative analysis of growth factor production in the mechanism of fibrosis in agnogenic myeloid metaplasia

Autor: Jeffrey Lipton, Allan D. Novetsky, Steve Lichter, Amit Goldberg, Jen C. Wang, Tsong H. Chang

Publikováno v: Experimental hematology. 34(12)

The current study quantified the growth factors in megakaryocytes and monocytes and correlated them to the degree of fibrosis, as there is no quantitative analysis of growth factors from megakaryocytes or monocytes reported in patients with agnogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b448f0ee226b4719c52d37c374e894ea
https://pubmed.ncbi.nlm.nih.gov/17157157

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Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation

Autor: Kirugaval C. Hemavathy, William Charles, Sramila Aithal, Tsong H. Chang, Jen C. Wang, Haowei Zhang, Allan D. Novetsky, Amit Goldberg

Publikováno v: Leukemia research. 30(1)

Agnogenic myeloid metaplasia (AMM) is characterized by bone marrow fibrosis and enhanced proliferation of megakaryocytes and CD34+ cells. We have analyzed the factors that could lead to reduced expression of TGF beta1RII in CD34+ cells of AMM patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bc0394cb8d3da973e7bbf30a2505e9
https://pubmed.ncbi.nlm.nih.gov/16054691

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GATA-1 Protein Levels Are Not Altered in CD34+ and CD61+ Cells, but NF-κb Protein Levels Are Elevated in Patients with Idiopathic Myelofibrosis

Autor: Seema Naik, Tsong H. Chang, Jen-Chin Wang, Chi Chen, Ying-Yi Xiao

Publikováno v: Blood. 112:4498-4498

GATA-1 and NF-kB are important in megakaryocytopoiesis and pathogenesis of idiopathic myelofibrosis (IMF). Previous studies have shown that GATA-1 levels were normal in mRNA but were lower in protein content in CD61+ cells of patients with IMF, and w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8dcb64cfe19b4525e7da4fa545ac9df5
https://doi.org/10.1182/blood.v112.11.4498.4498

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Megakaryocytes Cultured from Patients with IMF Produced Significantly Higher mRNA but Not Protein Levels of Fibrosing Grown Factors

Autor: Amit Goldberg, Jeffrey H. Lipton, Allan D. Novetsky, Steven Lichter, Jen-Chin Wang, Tsong H. Chang

Publikováno v: Blood. 108:3607-3607

Currently, the prevailing concept concerning the etiology of bone marrow fibrosis in patients with idiopathic myelofibrosis (IMF) is that it results from excessive production of fibrosing growth factors including transforming growth factor beta (TGF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddca612a2abe021d63fbf064829b81ff
https://doi.org/10.1182/blood.v108.11.3607.3607

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GATA-1 Protein Levels Are Not Altered and Are Correlated to the Jak-2 Mutation Status in Patients with Idiopathic Myelofibrosis (IMF)

Autor: Ying-Li Xiao, Tsong H Chang, Jen-Chin Wang, Alan B. Astrow, Brian Hunis

Publikováno v: Blood. 108:4919-4919

GATA-1 is important in megakaryocytopoiesis, and the fact that GATA-1low mice eventually develop myelofibrosis indicates that GATA-1 is important in the pathogenesis of idiopathic myelofibrosis (IMF). Previous study has shown that GATA-1 levels were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b555e9c9cf98bde27a37d78989a83f59
https://doi.org/10.1182/blood.v108.11.4919.4919

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