Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Tsing-Bau Chen"'
Autor:
Guo-Jun Zhang, Tsing-Bau Chen, Bohumil Bednar, Brett M. Connolly, Richard Hargreaves, Cyrille Sur, David L. Williams, Jr.
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 8, Pp 652-661 (2007)
The in vivo hollow fiber assay, in which semipermeable hollow fibers filled with tumor cells, are implanted into animals, was originally developed to screen for anticancer compounds before assessment in more complex tumor models. To enhance screening
Externí odkaz:
https://doaj.org/article/f61be8d57bf0423ebd7d0d809e7a396c
Autor:
Manishkumar Patel, Alexa Gleason, Stacey O'Malley, Brett Connolly, Donna Suresch, John Virostko, Neil Phillips, Shu-An Lin, Tsing-Bau Chen, Michael Klimas, Richard J Hargreaves, Cyrille Sur, David L Williams, Alvin C Powers, Bohumil Bednar
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106693 (2014)
BACKGROUND:Type 2 diabetes results from failure of the β-cells to compensate for increased insulin demand due to abnormal levels of metabolic factors. The ob/ob(lep-/-) mouse has been extensively studied as an animal model of type 2 diabetes. Previo
Externí odkaz:
https://doaj.org/article/b351acae3b4d448490f7d29ab48b6176
Autor:
Tsing-Bau Chen, Stephanie Villarreal, Renee C. Gaspar, Zhizhen Zeng, Rhonda Roberts, Lars Edvinsson, Sajedeh Eftekhari, Christopher A. Salvatore
Publikováno v:
Journal of Comparative Neurology. 524:90-118
Functional imaging studies have revealed that certain brainstem areas are activated during migraine attacks. The neuropeptide calcitonin gene-related peptide (CGRP) is associated with activation of the trigeminovascular system and transmission of noc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08ef292964ec64a573276adc84f0bd22
https://doi.org/10.1002/cne.23828
https://doi.org/10.1002/cne.23828
Autor:
Sara Johansson, Sajedeh Eftekhari, Lars Edvinsson, Zhizhen Zeng, Tsing-Bau Chen, Christopher A. Salvatore
Publikováno v:
Brain Research. 1600:93-109
Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated anti-migraine efficacy. One remaining question is where do these blockers act? We hypothesized that the trigeminal ganglion could be one possible site. We examined the bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8d8a232eee974e44660fb07698d9a7
https://doi.org/10.1016/j.brainres.2014.11.031
https://doi.org/10.1016/j.brainres.2014.11.031
Autor:
Richard Hargreaves, Maria Madeira, Patricia Miller, Joyce Powell, Richard Hajdu, Selena Fung, Lin-Lin Shiao, Mark Rosenbach, Ping Liu, Zhizhen Zeng, Qingmei Hong, Catherine Abbadie, Tsing-Bau Chen, Aniket Joshi, Wenping Li, Suzanne M. Mandala, Diane Posavec, Jacquelynn J. Cook, Bindhu V. Karanam, Ling Xu, Jenna L. Terebetski, Marc D. Chioda, Kerry Riffel, Nina Jochnowitz, Robert J. DeVita, Joseph F. Leone, David L. Williams, Mangay Williams, Ravi P. Nargund, Stacey O'Malley, Marie A. Holahan, Linus S. Lin, Sandra Sanabria, Raman K. Bakshi, Mona Purcell, Kathleen A. Sullivan, Yan Guo, Terence G. Hamill, James Dellureficio, Linda Chang, Harry R. Chobanian, Jessica Alexander, Gino Salituro, Hong Jin
Publikováno v:
ACS Medicinal Chemistry Letters. 4:509-513
We report herein the discovery of a fatty acid amide hydrolase (FAAH) positron emission tomography (PET) tracer. Starting from a pyrazole lead, medicinal chemistry efforts directed toward reducing lipophilicity led to the synthesis of a series of imi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed1503c306a4b117735b46a064c5a03
https://doi.org/10.1021/ml4000996
https://doi.org/10.1021/ml4000996
Autor:
Brett Connolly, Amy Vanko, Tsing-Bau Chen, Cyrille Sur, Weikang Tao, Joseph P. Davide, David L. Williams, Guo-Jun Zhang
Publikováno v:
Molecular Imaging and Biology
Purpose Visualization of the cell cycle in living subjects has long been a big challenge. The present study aimed to noninvasively visualize mitotic arrest of the cell cycle with an optical reporter in living subjects. Procedures An N-terminal cyclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c73a973235b539ebef8339460348385
http://europepmc.org/articles/PMC3708287
http://europepmc.org/articles/PMC3708287
Publikováno v:
Nature Protocols. 3:891-899
We have applied noninvasive optical imaging technology to the in vivo hollow fiber assay, using tumor cell lines in which optical reporters are expressed in response to activation/inhibition of a specific molecular pathway. In vivo noninvasive imagin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b84db6c418462389f82f89fbaaa93e
https://doi.org/10.1038/nprot.2008.52
https://doi.org/10.1038/nprot.2008.52
Autor:
Cyrille Sur, Brett Connolly, David L. Williams, Richard Hargreaves, Guo-Jun Zhang, Tsing-Bau Chen, Bohumil Bednar
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 8, Pp 652-661 (2007)
The in vivo hollow fiber assay, in which semipermeable hollow fibers filled with tumor cells, are implanted into animals, was originally developed to screen for anticancer compounds before assessment in more complex tumor models. To enhance screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d339d878083d752dd3061a049f9909
http://www.sciencedirect.com/science/article/pii/S1476558607800728
http://www.sciencedirect.com/science/article/pii/S1476558607800728
Autor:
J. Fred Hess, Kathryn L. Murphy, Mark G. Bock, Rick W. Ransom, Dai-Shi Su, Douglas J. Pettibone, Tsing-Bau Chen, R. S. L. Chang, Sookhee Ha, Pat J. Hey
Publikováno v:
Biochemistry. 45:14355-14361
We report the critical residues for the interaction of the kinins with human bradykinin receptor 1 (B1) using site-directed mutagenesis in conjunction with molecular modeling of the binding modes of the kinins in the homology model of the B1 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc55ace01757df410c1bda88fec544d
https://doi.org/10.1021/bi060673f
https://doi.org/10.1021/bi060673f
Autor:
Dennis C. Dean, David L. Williams, Zhizhen Zeng, Cyrille Sur, Patricia Miller, Tsing-Bau Chen, Yui Sing Tang
Publikováno v:
Nuclear Medicine and Biology. 33:555-563
We have characterized the interaction of the serotonin transporter ligand [3H]-N,N-dimethyl-2-(2-amino-4-cyanophenylthio)-benzylamine (DASB) with rhesus monkey brain in vitro using tissue homogenate binding and autoradiographic mapping. [3H]-DASB, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561b5c29e6aa82c019edecf97da27c14
https://doi.org/10.1016/j.nucmedbio.2006.02.007
https://doi.org/10.1016/j.nucmedbio.2006.02.007