Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Tsigkos, S"'
This review provides an overview of nonclinical in vivo models that can be used to support orphan designation in selected rare infectious diseases in Europe, with the aim to inform and stimulate the planning of nonclinical development in this area of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::1a9cc2b126c50595103f2d07ce5e7fc3
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3020938
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3020938
Autor:
Southall, N.T., Natarajan, M., Lau, L.P.L., Jonker, A.H., Deprez, B., Guilliams, T., Hunter, L., Rademaker, C.M.A., Hivert, V., Ardigo, D., Cavalla, D., Colvis, C., Hettne, K., t'Hoen, P.B., Kant, C., Krischer, J., Marin, F., Quintana, J., Rademaker, C., Reed, J., Southali, N., Tsigkos, S., Thompson, R., IRDiRC Data Min Repurposing Task
Publikováno v:
Orphanet Journal of Rare Diseases, 14(1). BMC
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-8 (2019)
Orphanet Journal of Rare Diseases, 14, 225. BMC
Orphanet Journal of Rare Diseases, 14(1). BioMed Central
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-8 (2019)
Orphanet Journal of Rare Diseases, 14, 225. BMC
Orphanet Journal of Rare Diseases, 14(1). BioMed Central
Orphanet Journal of Rare Diseases
The number of available therapies for rare diseases remains low, as fewer than 6% of rare diseases have an approved treatment option. The International Rare Diseases Research Consortium (IRDiRC) set up the multi-stakeholder Data Mining and Repurposin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6e5817b8707da5aa953bdc37580c8e
https://doi.org/10.1186/s13023-019-1193-3
https://doi.org/10.1186/s13023-019-1193-3
Autor:
Pyriochou, A.1, Tsigkos, S.2, Vassilakopoulos, T.2, Cottin, T.3, Zhou, Z.2, Gourzoulidou, E.4,5, Roussos, C.2, Waldmann, H.4,5, Giannis, A.3, Papapetropoulos, A.1,2 apapapet@upatras.gr
Publikováno v:
British Journal of Pharmacology. Dec2007, Vol. 152 Issue 8, p1207-1214. 8p. 2 Black and White Photographs, 1 Diagram, 4 Graphs.
Autor:
Westermark, K, Holm, Bb, Söderholm, M, Llinares Garcia, J, Rivière, F, Aarum, S, Butlen Ducuing, F, Tsigkos, S, Wilk Kachlicka, A, N'Diamoi, C, Borvendég, J, Lyons, D, Sepodes, B, Bloechl Daum, B, Lhoir, A, Todorova, M, Kkolos, I, Kubáčková, K, Bosch Traberg, H, Tillmann, V, Saano, V, Héron, E, Elbers, R, Siouti, M, Eggenhofer, J, Salmon, P, Clementi, Maurizio, Krieviņš, D, Matulevičiene, A, Metz, H, Vincenti, Ac, Voordouw, A, Dembowska Bagińska, B, Nunes, Ac, Saleh, Fm, Foltánová, T, Možina, M, Farnell J, Torrent i., Beerman, B, Mariz, S, Evers, Mp, Greene, L, Thorsteinsson, S, Gramstad, L, Mavris, M, Bignami, F, Lorence, A, Belorgey, C, Committee for Orphan Medicinal Products, the European Medicines
Publikováno v:
Nature Reviews Drug Discovery. 10:341-349
In 2000, regulation on orphan medicinal products was adopted in the European Union with the aim of benefiting patients who suffer from serious, rare conditions for which there is currently no satisfactory treatment. Since then, more than 850 orphan d
Background and purpose: Angiopoietins (Ang) are crucial for new blood vessel formation and exert their effects by acting on the Tie2 receptor. We have recently described a sulindac analogue 2-((1E,Z)-1-benzylidene-5-bromo-2-methyl-1H-inden-3yl) aceti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::27501d200bdb05289e667d383161a6ad
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3137222
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3137222
Background: Human rhinoviruses, major precipitants of asthma exacerbations, infect the lower airway epithelium inducing inflammation. The possibility that viral infection may mediate angiogenesis, thus contributing to airway remodeling, has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::aeccaa8bc8bf4b02792a81c6d771d40c
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3004655
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3004655
Angiopoietin-2 (Ang2) is a Tie-2 ligand that destabilizes vascular structures, allowing for neovascularization or vessel regression depending on local vascular endothelial cell growth factor (VEGF) concentrations. Although various stimuli have been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::fe5952ac57488f683b41c88ccf61dd5a
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3099434
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3099434
Autor:
Roviezzo, F. Tsigkos, S. Kotanidou, A. Bucci, M. Brancaleone, V. Cirino, G. Papapetropoulos, A.
Angiopoietins (Angs) are endothelium-selective ligands that exert most of their actions through the Tie-2 receptor. It is widely accepted that Ang-1 promotes the structural integrity of blood vessels and exhibits anti-inflammatory properties. In cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::3f9a1637d7f99c6c340d73d5a4ef01f6
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3063019
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3063019
The angiopoietin (Ang) family of growth factors includes four members, all of which bind to the endothelial receptor tyrosine kinase Tie2. Two of the Angs, Ang-1 and Ang-4, activate the Tie2 receptor, whereas Ang-2 and Ang-3 inhibit Ang-1-induced Tie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0f4499e5e5ca195607e9febeedbb3df9
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3083778
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3083778
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