Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Tshering D Lama-Sherpa"'
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Akademický článek
AKAP13 couples GPCR signaling to mTORC1 inhibition.
Autor: Shihai Zhang, Huanyu Wang, Chase H Melick, Mi-Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Tshering D Lama-Sherpa, Delong Meng, Kelly A Servage, Nicholas G James, Jenna L Jewell
Publikováno v: PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focuse
Externí odkaz: https://doaj.org/article/358b3427813548ef951b4b856085d782
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2
Regulation of mTORC1 by the Rag GTPases
Autor: Tshering D. Lama-Sherpa, Mi-Hyeon Jeong, Jenna L. Jewell
Publikováno v: Biochemical Society Transactions. 51:655-664
The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator of cell growth. mTORC1 hyperactivation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca2cb05c3cc17541947aa7d6b8eaf18b
https://doi.org/10.1042/bst20210038
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3
Data from Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor Landscape
Autor: Lalita A. Shevde, Rajeev S. Samant, Anna G. Sorace, Heba A. Alsheikh, Patrick N. Song, Sarah C. Kammerud, Dominique C. Hinshaw, Shamik Das, Tshering D. Lama-Sherpa
Metastases account for the majority of mortalities related to breast cancer. The onset and sustained presence of hypoxia strongly correlates with increased incidence of metastasis and unfavorable prognosis in patients with breast cancer. The Hedgehog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2a2bcaa49a57c372392c04f0756b8fe
https://doi.org/10.1158/1541-7786.c.6545070.v1
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6
Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor Landscape
Autor: Sarah C. Kammerud, Rajeev S. Samant, Anna G. Sorace, Tshering D. Lama-Sherpa, Lalita A. Shevde, Heba Allah Alsheikh, Shamik Das, Patrick N. Song, Dominique C. Hinshaw
Publikováno v: Molecular Cancer Research. 20:150-160
Metastases account for the majority of mortalities related to breast cancer. The onset and sustained presence of hypoxia strongly correlates with increased incidence of metastasis and unfavorable prognosis in breast cancer patients. The Hedgehog (Hh)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::070509e7b933b04500a527f6c148ed91
https://doi.org/10.1158/1541-7786.mcr-21-0257
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7
SNAT7 regulates mTORC1 via macropinocytosis
Autor: Delong Meng, Qianmei Yang, Mi-Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Chase H. Melick, Tshering D. Lama-Sherpa, Huanyu Wang, Mariela Huerta-Rosario, Greg Urquhart, Lauren G. Zacharias, Cheryl Lewis, Ralph J. DeBerardinis, Jenna L. Jewell
Publikováno v: Proceedings of the National Academy of Sciences. 119
Mammalian target of rapamycin complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Some amino acids signal to mTORC1 through the Rag GTPase, whereas glutamine and asparagine activate mTORC1 through a Rag GTPase-ind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9521634e45051170a76c4d194e6c52a6
https://doi.org/10.1073/pnas.2123261119
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8
AKAP13 couples GPCR signaling to mTORC1 inhibition
Autor: Shweta Tiwary, Tshering D. Lama-Sherpa, Delong Meng, Shihai Zhang, Jenna L. Jewell, Nicholas G. James, Mi Hyeon Jeong, Chase H. Melick, Adna Curukovic, Huanyu Wang, Kelly A. Servage
Publikováno v: PLoS Genetics
PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focuse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a684702ef1d317e7e86038ccd65c13f
http://europepmc.org/articles/PMC8570464
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9
Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding
Autor: Brandon J. Metge, Dominique C. Hinshaw, Mateus Mota, Chae-Myeong Ha, Noha Sharafeldin, Tshering D. Lama-Sherpa, Adam R. Wende, Heba Allah Alsheikh, Lalita A. Shevde, Sarah C. Kammerud, Rajeev S. Samant
Publikováno v: Cancer Lett
Obesity and diabetes cumulatively create a distinct systemic metabolic pathophysiological syndrome that predisposes patients to several diseases including breast cancer. Moreover, diabetic and obese women with breast cancer show a significant increas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba56e62680142f729b90654e3862f023
https://europepmc.org/articles/PMC8740596/
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10
G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation
Autor: Chase H. Melick, Tshering D. Lama-Sherpa, Adna Curukovic, Jenna L. Jewell
Publikováno v: Molecular pharmacology. 101(4)
The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism, growth, and autophagy. Increased activation of mTOR complex 1 (mTORC1) is typically observed in human disease and continues t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602ba9e3eb3c6edd0fd0f9f6c1f513cc
https://pubmed.ncbi.nlm.nih.gov/34965982
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