Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Tse‐Hua Tan"'
Autor:
Hsiao-Han Lin, Cheng-Wei Chang, Yu-Ting Liao, Shauh-Der Yeh, Hsiu-Ping Lin, Hui-Min Ho, Chantal Hoi-Yin Cheung, Hsueh-Fen Juan, Yi-Rong Chen, Yu-Wen Su, Li-Mei Chen, Tse-Hua Tan, Wen-Jye Lin
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our study demonstrated that decreased DUSP22 expression is associated with shorter disea
Externí odkaz:
https://doaj.org/article/9070ec439dfa49ff8d34cbdafe135424
Autor:
I-Tsu Chyuan, Hsiu-Jung Liao, Tse-Hua Tan, Huai-Chia Chuang, Yu-Chuan Chu, Meng-Hsun Pan, Chien-Sheng Wu, Ching-Liang Chu, Bor-Ching Sheu, Ping-Ning Hsu
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-16 (2024)
Abstract Background T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that transduces apoptotic
Externí odkaz:
https://doaj.org/article/bfe955ba0c0042ae99e7e6e66da63154
Autor:
Ying-Chun Shih, Hsueh-Fen Chen, Chia-Ying Wu, Yi-Ru Ciou, Chia-Wen Wang, Huai-Chia Chuang, Tse-Hua Tan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract DUSP22 is a dual-specificity phosphatase that inhibits T cell activation by inactivating the kinase Lck. Here we show that the E3 ubiquitin ligase UBR2 is a positive upstream regulator of Lck during T-cell activation. DUSP22 dephosphorylates
Externí odkaz:
https://doaj.org/article/74ada20324de4b6ca3ec165d10c91490
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-26 (2023)
Abstract Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against several chronic diseases. Besides chronic diseases, ACE2 is the host receptor for SARS-CoV or SARS-CoV-2 virus, mediatin
Externí odkaz:
https://doaj.org/article/febcbf663ce94e31a8ff99aa9768d4c0
Autor:
Huai-Chia Chuang, Chia-Hsin Hsueh, Pu-Ming Hsu, Ching-Yi Tsai, Ying-Chun Shih, Hsien-Yi Chiu, Yi-Ming Chen, Wen-Kuang Yu, Ming-Han Chen, Tse-Hua Tan
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Dual-specificity phosphatase 8 (DUSP8) is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of DUSP8 in T cells remains unclear. Using T cell–specific Dusp8 cond
Externí odkaz:
https://doaj.org/article/f37e99b47c2e42e8982271f79bee0148
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Dual-specificity phosphatases (DUSPs) can dephosphorylate both tyrosine and serine/threonine residues of their substrates and regulate T cell-mediated immunity and autoimmunity. The aim of this study was to investigate the potenti
Externí odkaz:
https://doaj.org/article/5bdb14d1afbf4c02a1469beb2baccc6f
Autor:
Huai‐Chia Chuang, Chia‐Hsin Hsueh, Pu‐Ming Hsu, Rou‐Huei Huang, Ching‐Yi Tsai, Nai‐Hsiang Chung, Yen‐Hung Chow, Tse‐Hua Tan
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp 1-18 (2022)
Abstract ACE2 on epithelial cells is the SARS‐CoV‐2 entry receptor. Single‐cell RNA‐sequencing data derived from two COVID‐19 cohorts revealed that MAP4K3/GLK‐positive epithelial cells were increased in patients. SARS‐CoV‐2‐induced
Externí odkaz:
https://doaj.org/article/51c0e30c8182433d87959ca3893a8445
Autor:
Hua Wang, Rohan Moniruzzaman, Lei Li, Baoan Ji, Yi Liu, Xiangsheng Zuo, Reza Abbasgholizadeh, Jun Zhao, Guangchao Liu, Ruiqi Wang, Hongli Tang, Ryan Sun, Xiaoping Su, Tse-Hua Tan, Anirban Maitra, Huamin Wang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Ras plays an essential role in the development of acinar-to-ductal metaplasia (ADM) and pancreatic ductal adenocarcinoma (PDAC). However, mutant Kras is an inefficient driver for PDAC development. The mechanisms of the switching from low Ras activity
Externí odkaz:
https://doaj.org/article/387208fdd37b4d7fa8c9d084ec53be4a
Autor:
Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan, Yi-Rong Chen
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-14 (2022)
Abstract Background Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities. Dual specificity phosphatase 3 (DUSP3), a suppressor of
Externí odkaz:
https://doaj.org/article/85ceada134e8423ba5108b0f13ee2d0a
Autor:
Cherng-Shyang Chang, Wen-Hsuan Yu, Chang-Chao Su, Jhen-Wei Ruan, Chiao-Mei Lin, Chih-Ting Huang, Yi-Ting Tsai, I-Jung Lin, Chao-Yang Lai, Tsung-Hsien Chuang, Wen-Jye Lin, Tse-Hua Tan, Hsuan-Cheng Huang, Hsueh-Fen Juan, Cheng-Yuan Kao
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103738- (2022)
Summary: Single-cell RNA sequencing (scRNA-seq) approach can broadly and specifically evaluate the individual cells with minimum detection bias. To explore the individual compositional and transcriptional alteration of intestinal leukocytes in the Du
Externí odkaz:
https://doaj.org/article/4f65673e087a4d40bdb5e3d0a441551a