An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells.

Autor: Kyriazi D; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Voth L; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Bader A; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Ewert W; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany.; Institute for Functional Gene Analytics (IFGA), Bonn-Rhein-Sieg University of Applied Sciences, Rheinbach, Germany., Gerlach J; Faculty of Chemistry, TU Dresden, Dresden, Germany., Elfrink K; Institute of Integrative Cell Biology and Physiology, University of Münster, Münster, Germany., Franz P; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Tsap MI; Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany., Schirmer B; Institute of Pharmacology, Hannover Medical School, Hannover, Germany., Damiano-Guercio J; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Hartmann FK; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Plenge M; Department of Cell Physiology and Biophysics, Institute of Cell Biology and Biophysics, Leibniz Universität Hannover, Hannover, Germany., Salari A; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Schöttelndreier D; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Strienke K; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Bresch N; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Salinas C; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Gutzeit HO; Department of Biology, TU Dresden, Dresden, Germany., Schaumann N; Institute for Pathology, Hannover Medical School, Hannover, Germany., Hussein K; Institute of Pathology, KRH Klinikum Nordstadt, Hannover, Germany., Bähre H; Research Core Unit Mass Spectrometry-Metabolomics, Hannover Medical School, Hanover, Germany., Brüsch I; Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany., Claus P; SMATHERIA gGmbH-Non-Profit Biomedical Research Institute, Hannover, Germany., Neumann D; Institute of Pharmacology, Hannover Medical School, Hannover, Germany., Taft MH; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany., Shcherbata HR; Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany., Ngezahayo A; Department of Cell Physiology and Biophysics, Institute of Cell Biology and Biophysics, Leibniz Universität Hannover, Hannover, Germany., Bähler M; Institute of Integrative Cell Biology and Physiology, University of Münster, Münster, Germany., Amiri M; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Knölker HJ; Faculty of Chemistry, TU Dresden, Dresden, Germany., Preller M; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany.; Institute for Functional Gene Analytics (IFGA), Bonn-Rhein-Sieg University of Applied Sciences, Rheinbach, Germany., Tsiavaliaris G; Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany. Tsiavaliaris.Georgios@mh-hannover.de.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 16; Vol. 15 (1), pp. 9947. Date of Electronic Publication: 2024 Nov 16.