Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tsai-Chun Lai"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The effective treatment of breast cancer remains a profound clinical challenge, especially due to drug resistance and metastasis which unfortunately arise in many patients. The transcription inhibitor 5,6-dichloro-1-beta-D-ribofuranosyl-benz
Externí odkaz:
https://doaj.org/article/a23c1da0c58b4b2f821f6d3d0d50d8e4
Autor:
Tsai-Chun Lai, Yu-Chen Chen, Hui-Hua Cheng, Tzu-Lin Lee, Jaw-Shiun Tsai, I.-Ta Lee, Kuo-Ti Peng, Chiang-Wen Lee, Lee-Fen Hsu, Yuh-Lien Chen
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-22 (2022)
Abstract Background Cardiovascular diseases (CVDs) are related to particulate matter (PM2.5) exposure. Researchers have not clearly determined whether hyperglycemia, a hallmark of diabetes, exacerbates PM2.5-induced endothelial damage. Thus, this stu
Externí odkaz:
https://doaj.org/article/81f57a31b97e43f4a36709cbabf8224b
Autor:
Yu-Chen Chen, Tzu-Yi Chuang, Chen-Wei Liu, Chi-Wei Liu, Tzu-Lin Lee, Tsai-Chun Lai, Yuh-Lien Chen
Publikováno v:
Particle and Fibre Toxicology, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background Particulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress increased the expressi
Externí odkaz:
https://doaj.org/article/882afa52e2824cf9a27dc5d0d67c8074
Autor:
Tsai-Chun Lai, Tzu-Lin Lee, Yu-Chun Chang, Yu-Chen Chen, Shu-Rung Lin, Shu-Wha Lin, Chi-Ming Pu, Jaw-Shiun Tsai, Yuh-Lien Chen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Cardiovascular disease is a major health problem in industrialized and developing countries and is the leading cause of death and disability. Myocardial ischemia/reperfusion (I/R) causes cardiomyocyte damage such as apoptosis and hypertrophy. The pur
Externí odkaz:
https://doaj.org/article/3e58461d0de748459506825f92edb311
Autor:
Tzu-Lin Lee, Ming-Hsueh Lee, Yu-Chen Chen, Yi-Chieh Lee, Tsai-Chun Lai, Hugo You-Hsien Lin, Lee-Fen Hsu, Hsin-Ching Sung, Chiang-Wen Lee, Yuh-Lien Chen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Myocardial infarction is the leading cause of morbidity and mortality worldwide. Although myocardial reperfusion after ischemia (I/R) is an effective method to save ischemic myocardium, it can cause adverse reactions, including increased oxidative st
Externí odkaz:
https://doaj.org/article/8fa70257bbf440eda3a51077d8a0c2fb
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is involved in the synthesis of active steroid hormones. Two human 3β-HSD isoforms are expressed in a tissue-specific pattern. HSD3B1 (type I) expression is essential to produc
Externí odkaz:
https://doaj.org/article/e1f23b51de7445fcae7c171b16fdaee1
Autor:
Yu-Chen Chen, Tzu Yi Chuang, Chiang-Wen Lee, Yuh-Lien Chen, I. Ta Lee, Hsin Ching Sung, Tzu Lin Lee, Tsai Chun Lai
Publikováno v:
Cell Biology and Toxicology
Graphical abstract Previous work has shown an association between vitamin D3 deficiency and an increased risk for acquiring various inflammatory diseases. Vitamin D3 can reduce morbidity and mortality in these patients via different mechanisms. Lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30021d3e691be0e93f0635c1479f6ce1
https://doi.org/10.1007/s10565-021-09629-6
https://doi.org/10.1007/s10565-021-09629-6
Autor:
Shu-Rung Lin, Chiang-Wen Lee, Yu-Chen Chen, Chi-Ming Pu, I-Ta Lee, Jaw-Shiun Tsai, Tzu-Lin Lee, Shu-Wha Lin, Yuh-Lien Chen, Tsai-Chun Lai
Publikováno v:
Theranostics
Rationale: Cardiovascular diseases, such as myocardial infarction (MI), are the leading causes of death worldwide. Reperfusion therapy is the common standard treatment for MI. However, myocardial ischemia/reperfusion (I/R) causes cardiomyocyte injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5547797337077c764c420fbe4086a2ef
https://doi.org/10.7150/thno.52677
https://doi.org/10.7150/thno.52677
Autor:
Chi-Wei Liu, Tsai-Chun Lai, Tzu-Lin Lee, Tzu Yi Chuang, Yu-Chen Chen, Chen-Wei Liu, Yuh-Lien Chen
Publikováno v:
Particle and Fibre Toxicology, Vol 17, Iss 1, Pp 1-14 (2020)
Particle and Fibre Toxicology
Particle and Fibre Toxicology
Background Particulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress increased the expression of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95284c274a7514adc495c2eba480d1e8
http://link.springer.com/article/10.1186/s12989-020-00373-z
http://link.springer.com/article/10.1186/s12989-020-00373-z
Autor:
Meng Chun Hu, Tsai-Chun Lai
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Liver receptor homologue-1 (LRH-1) plays a critical role in hepatic metabolism and disease. Here we show that LRH-1 protein stability is regulated by the cullin 4 (CUL4) E3 ubiquitin ligase complex. We found that DNA damage-binding protein 2 (DDB2) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373c8ef0f5407f4b49175d111ed42cd0
https://pubmed.ncbi.nlm.nih.gov/30923324
https://pubmed.ncbi.nlm.nih.gov/30923324