Inhibition of de novo pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer.

Autor: Phan T; Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010., Nguyen VH; Department of Hematology, City of Hope National Medical Center, Duarte, CA 91010., Buettner R; Department of Hematology, City of Hope National Medical Center, Duarte, CA 91010., Morales C; Department of Hematology, City of Hope National Medical Center, Duarte, CA 91010., Yang L; Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544., Wong P; Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010., Tsai W; Department of Hematology, City of Hope National Medical Center, Duarte, CA 91010., Salazar MD; Department of Hematology, City of Hope National Medical Center, Duarte, CA 91010., Gil Z; Rambam Medical Center, Israel., Diamond DJ; Department of Hematology, City of Hope National Medical Center, Duarte, CA 91010., Rabinowitz JD; Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544., Rosen S; Department of Hematology, City of Hope National Medical Center, Duarte, CA 91010., Melstrom LG; Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010.

Publikováno v: International journal of biological sciences [Int J Biol Sci] 2021 Jun 01; Vol. 17 (9), pp. 2240-2251. Date of Electronic Publication: 2021 Jun 01 (Print Publication: 2021).