Tsa1 is the dominant peroxide scavenger and a source of H 2 O 2 -dependent GSSG production in yeast.

Autor: Zimmermann J; Institute of Biochemistry, Centre for Human and Molecular Biology (ZHMB), Saarland University, 66123 Saarbrücken, Germany., Lang L; Faculty of Chemistry, Comparative Biochemistry, RPTU Kaiserslautern, D-67663 Kaiserslautern, Germany., Calabrese G; Institute for Biochemistry, Redox Biochemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Laporte H; Institute of Biochemistry, Centre for Human and Molecular Biology (ZHMB), Saarland University, 66123 Saarbrücken, Germany., Amponsah PS; Institute of Biochemistry, Centre for Human and Molecular Biology (ZHMB), Saarland University, 66123 Saarbrücken, Germany; Cellular Biochemistry, RPTU Kaiserslautern, 67663 Kaiserslautern, Germany., Michalk C; Cellular Biochemistry, RPTU Kaiserslautern, 67663 Kaiserslautern, Germany., Sukmann T; Institute of Biochemistry, Centre for Human and Molecular Biology (ZHMB), Saarland University, 66123 Saarbrücken, Germany., Oestreicher J; Institute of Biochemistry, Centre for Human and Molecular Biology (ZHMB), Saarland University, 66123 Saarbrücken, Germany., Tursch A; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Peker E; Institute for Biochemistry, Redox Biochemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Owusu TNE; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Weith M; Institute for Biochemistry, Redox Biochemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany., Roma LP; Institute of Biophysics, Centre for Human and Molecular Biology (ZHMB), Saarland University, 66424 Homburg, Germany., Deponte M; Faculty of Chemistry, Comparative Biochemistry, RPTU Kaiserslautern, D-67663 Kaiserslautern, Germany. Electronic address: deponte@chemie.uni-kl.de., Riemer J; Institute for Biochemistry, Redox Biochemistry, University of Cologne, Zuelpicher Str. 47a/R. 3.49, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany. Electronic address: jan.riemer@uni-koeln.de., Morgan B; Institute of Biochemistry, Centre for Human and Molecular Biology (ZHMB), Saarland University, 66123 Saarbrücken, Germany. Electronic address: bruce.morgan@uni-saarland.de.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2024 Nov 06. Date of Electronic Publication: 2024 Nov 06.

Estudos estruturais e funcionais de Tsa1 de Saccharomyces cerevisiae: um modelo biológico para o estudo de inibidores de crescimento celular para leucemia linfoide aguda

Autor: Santos, Melina Cardoso dos

As peroxirredoxinas (Prx) são enzimas antioxidantes que se destacam pela capacidade de decompor uma grande variedade de hidroperóxidos com elevada eficiência (106-108M-1s-1), mantendo essas moléculas em níveis adequados à homeostase celular. En

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/9/9134/tde-18102017-143906/

Nitro-Oleic Acid-Mediated Nitroalkylation Modulates the Antioxidant Function of Cytosolic Peroxiredoxin Tsa1 during Heat Stress in Saccharomyces cerevisiae

Autor: Lorena Aranda-Caño, Raquel Valderrama, José Rafael Pedrajas, Juan C. Begara-Morales, Mounira Chaki, María N. Padilla, Manuel Melguizo, Francisco Javier López-Jaramillo, Juan B. Barroso

Publikováno v: Antioxidants, Vol 11, Iss 5, p 972 (2022)

Heat stress is one of the abiotic stresses that leads to oxidative stress. To protect themselves, yeast cells activate the antioxidant response, in which cytosolic peroxiredoxin Tsa1 plays an important role in hydrogen peroxide removal. Concomitantly

Externí odkaz: https://doaj.org/article/5541e693bdef4d46b9e2668900f0e470

Peroxiredoxin Tsa1 Is the Key Peroxidase Suppressing Genome Instability and Protecting against Cell Death in Saccharomyces cerevisiae.

Autor: Iraqui, Ismail¹, Kienda, Guy¹, Soeur, Jérémie¹, Faye, Gérard¹, Baldacci, Giuseppe¹, Kolodner, Richard D.², Meng-Er Huang¹

Publikováno v: PLoS Genetics. Jun2009, Vol. 5 Issue 6, p1-14. 14p. 2 Black and White Photographs, 1 Diagram, 2 Charts, 3 Graphs.

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