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Akademický článek

Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3.

Autor: Wen Hwa Lee, Elisabeth Schaffner-Reckinger, Demokritos C Tsoukatos, Kelly Aylward, Vassilios Moussis, Vassilios Tsikaris, Paraskevi Trypou, Marion Egot, Dominique Baruch, Nelly Kieffer, Christilla Bachelot-Loza

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0134952 (2015)

Agonist-stimulated platelet activation triggers conformational changes of integrin αIIbβ3, allowing fibrinogen binding and platelet aggregation. We have previously shown that an octapeptide, p1YMESRADR8, corresponding to amino acids 313-320 of the

Externí odkaz: https://doaj.org/article/02f6cc7527ea44f0a394fd7b92417bb0

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A highly constrained cyclic (S,S)-CDC- peptide is a potent inhibitor of carotid artery thrombosis in rabbits

Autor: Roussa, V. D., Stathopoulou, E. M., Papamichael, N. D., Englezopoulos, C. V., Rousouli, K. I., Trypou, P., Moussis, V., Tellis, C. C., Katsouras, C. S., Tsikaris, V., Tselepis, A. D., Michalis, L. K.

Inhibition of platelet aggregation is indispensable for the treatment of acute arterial thrombotic episodes. We have previously reported the synthesis of a highly constrained cyclic peptide, that incorporates the -CDC- sequence, (S,S) PSRCDCR-NH(2),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::f160e70d9e736ce2dc0a7a2065787318
http://olympias.lib.uoi.gr/jspui/handle/123456789/10246