Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tryphon Mazu"'
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 16:555-578
Pathogenic fungi are a major causative group for opportunistic infections (OIs). AIDS patients and other immunocompromised individuals are at risk for OIs, which if not treated appropriately, contribute to the mortality associated with their conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d563d9c0a7c19197afa9ac950d48b7
https://doi.org/10.2174/1389557516666160118112103
https://doi.org/10.2174/1389557516666160118112103
Publikováno v:
Biologics : Targets & Therapy
Miles D Freeman, Tryphon Mazu, Jana S Miles, Selina Darling-Reed, Hernan Flores-Rozas College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, USA Abstract: The SWI/SNF chromatin-remodeling complex plays an essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2276312ca82246ff5d626ab68360fe5
https://www.dovepress.com/inactivation-of-chromatin-remodeling-factors-sensitizes-cells-to-selec-peer-reviewed-article-BTT
https://www.dovepress.com/inactivation-of-chromatin-remodeling-factors-sensitizes-cells-to-selec-peer-reviewed-article-BTT
Autor:
Sidney Bolden, Tryphon Mazu, Seth Y. Ablordeppey, Hernan Flores-Rozas, Xue Y. Zhu, Jagan R. Etukala, Shabana I. Khan, Comfort A. Boateng, Melissa R. Jacob, Larry A. Walker
Opportunistic infections are devastating to immunocompromised patients. And in especially sub-Saharan Africa where the AIDS epidemic is still raging, the mortality rate was recently as high as 70%. The paucity of anti-opportunistic drugs, the decreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb011101263cfd9eb979a4bfffd87605
https://europepmc.org/articles/PMC3870201/
https://europepmc.org/articles/PMC3870201/
Autor:
Miles D. Freeman, Jana S. Miles, R. Renee Reams, Tryphon Mazu, Hernan Flores-Rozas, Adrienne P. Stephenson
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2013 (2013)
BioMed Research International, Vol 2013 (2013)
Manganese (Mn) is essential for normal physiologic functioning; therefore, deficiencies and excess intake of manganese can result in disease. In humans, prolonged exposure to manganese causes neurotoxicity characterized by Parkinson-like symptoms. Mn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75146e775a5f13bf10932ee514bab13
Autor:
Shabana I. Khan, Tryphon Mazu, Larry A. Walker, Jagan R. Etukala, Melissa R. Jacob, Seth Y. Ablordeppey
Publikováno v:
European journal of medicinal chemistry. 46(6)
Previous studies have indicated that the δ-carboline (2) ring system derived from the natural product cryptolepine (1) may represent a pharmacophore for anti-infective activity. This paper describes the design and synthesis of a small library of sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531cdaca084f52bcfbbdc2537d7c0277
https://pubmed.ncbi.nlm.nih.gov/21459492
https://pubmed.ncbi.nlm.nih.gov/21459492
Autor:
Jagan R. Etukala, Larry A. Walker, Shabana I. Khan, Seth Y. Ablordeppey, Tryphon Mazu, Melissa R. Jacob, Xue Y. Zhu
Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473a441322891a42a2ebcd88dc050942
https://europepmc.org/articles/PMC3014406/
https://europepmc.org/articles/PMC3014406/
Autor:
Olufisayo O. Salako, Byron J. Aguilar, Rosemary A. Poku, Tryphon Mazu, Augustine T. Nkembo, Hernan Flores-Rozas, Nazarius S. Lamango
Publikováno v:
Cancer Research. 75:2035-2035
Pancreatic cancer (PC) incidence is a major healthcare problem as the five-year survival rate remains below 5%. Over 90% of PC cases harbor the hyperactive K-Ras mutant protein. Polyisoprenylation processes facilitate the proper localization and sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb8dab899c10e2124b85ea032b8dade6
https://doi.org/10.1158/1538-7445.am2015-2035
https://doi.org/10.1158/1538-7445.am2015-2035
Autor:
Rosemary A. Poku, Nazarius S. Lamango, Olufisayo O. Salako, Felix Amissah, Augustine T. Nkembo, Hernan Flores-Rozas, Tryphon Mazu
Publikováno v:
Cancer Research. 75:5090-5090
Background: Metastatic castration-resistant prostate cancer (mCRPC) poses a major clinical management challenge due to lack of effective therapies. Monomeric G- proteins of the Ras superfamily such as Rho, Rac and Cdc42 are critical mediators in pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a158deaf679163240610620372adeb7
https://doi.org/10.1158/1538-7445.am2015-5090
https://doi.org/10.1158/1538-7445.am2015-5090
Publikováno v:
Cancer Research. 75:2545-2545
Anthracyclines constitute drugs of choice as single agents or in combination therapy in cancers that are refractory to other therapies, such as triple negative breast cancer, commonly observed in African-American women (AA) and is characterized for l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01f2b45a067a818a4e85500bcc5d9183
https://doi.org/10.1158/1538-7445.am2015-2545
https://doi.org/10.1158/1538-7445.am2015-2545
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 23:C50-C50
Breast cancer is the most common cancer in women worldwide. African-American women (AA) tend to have more aggressive breast cancers that present more frequently as estrogen receptor, progesterone receptor (PR) and HER2 negative which are referred to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b63a2e27287d4f5b0eee895ab4e95315
https://doi.org/10.1158/1538-7755.disp13-c50
https://doi.org/10.1158/1538-7755.disp13-c50