Výsledky vyhledávání - "Trypanosomiasis/genetics"

Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis

Autor: Magdalena Radwanska, Stefan Magez, Hang Thi Thu Nguyen, Robin B. Guevarra

Publikováno v: PLoS Pathogens
PLOS PATHOGENS
PLoS Pathogens, Vol 17, Iss 11, p e1010026 (2021)

Salivarian trypanosomes are extracellular protozoan parasites causing infections in a wide range of mammalian hosts, with Trypanosoma evansi having the widest geographic distribution, reaching territories far outside Africa and occasionally even Euro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47e3f7f7cb5d23162e5d5c18750af98
https://pubmed.ncbi.nlm.nih.gov/34762705

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Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism*

Autor: Susan Wyllie, Paul G. Wyatt, Alan H. Fairlamb, Malcolm F. G. Stevens, Geoffrey Wells, Janine König

Publikováno v: The Journal of Biological Chemistry

Better drugs are urgently needed for the treatment of African sleeping sickness. We tested a series of promising anticancer agents belonging to the 4-substituted 4-hydroxycyclohexa-2,5-dienones class ("quinols") and identified several with potent try

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644701f01b2fea36b4b7629a41fa03c3
http://europepmc.org/articles/PMC3048735

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