Zobrazeno 1 - 10
of 557
pro vyhledávání: '"Trypanocidal Agent"'
Autor:
Isabella Coimbra Vila Nova, Leyllane Rafael Moreira, Diego José Lira Torres, Kamila Kássia dos Santos Oliveira, Leydianne Leite de Siqueira Patriota, Luana Cassandra Breitenbach Barroso Coelho, Patrícia Maria Guedes Paiva, Thiago Henrique Napoleão, Virgínia Maria Barros de Lorena, Emmanuel Viana Pontual
Publikováno v:
Antibiotics, Vol 9, Iss 8, p 515 (2020)
Trypanosoma cruzi causes the lethal Chagas disease, which is endemic in Latin America. Flowers of Moringa oleifera (Moringaceae) express a trypsin inhibitor (MoFTI) whose toxicity to T. cruzi trypomastigotes was previously reported. Here, we studied
Externí odkaz:
https://doaj.org/article/17cd0bf88e8c4afc92829f6b5ce3fc43
Autor:
Alonzo González-González, Oscar Sánchez-Sánchez, R. Luise Krauth-Siegel, Maria Laura Bolognesi, Rogelio Gớmez-Escobedo, Benjamín Nogueda-Torres, Lenci K. Vázquez-Jiménez, Emma Saavedra, Rusely Encalada, José Carlos Espinoza-Hicks, Alma D. Paz-González, Gildardo Rivera
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13315
American trypanosomiasis is a worldwide health problem that requires attention due to ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives against trypomastigotes of the Trypanosoma cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803cde7b31a7080142bfe3b173ac4946
Autor:
Nora Andrea Gutiérrez-Nágera, José G. Trujillo-Ferrara, Elaheh Mirzaeicheshmeh, Roberto I. Cuevas-Hernández, Sarai Martínez-Cerón
Publikováno v:
Parasitology Research. 120:2905-2918
Current treatments for Chagas disease have a limited impact during the chronic stage and trigger severe side effects. Treatments target Trypanosoma cruzi, the etiological agent of the disease. The aims of this study were to evaluate the trypanocidal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171eb680f196de47add6fffce54d5eb1
https://doi.org/10.1007/s00436-021-07137-4
https://doi.org/10.1007/s00436-021-07137-4
Autor:
Katielle Albuquerque Freire, Dânya Bandeira Lima, Alice Maria Costa Martins, Vani Xavier Oliveira, Marcelo D. T. Torres, Ramon Róseo Paula Pessoa Bezerra de Menezes, Marília Lopes Monteiro
Publikováno v:
Toxicon. 181:71-78
Chagas disease is caused by Trypanosoma cruzi and affects approximately 10 million people a year worldwide. The only two treatment options, benznidazole and nifurtimox, have low efficacy and high toxicity towards human cells. Mastoporan peptide (MP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0d4824e9d9a2572c277f08b616a975
https://doi.org/10.1016/j.toxicon.2020.04.099
https://doi.org/10.1016/j.toxicon.2020.04.099
Autor:
Santo Previti, Roberta Ettari, Carla Di Chio, Rahul Ravichandran, Marta Bogacz, Ute A. Hellmich, Tanja Schirmeister, Sandro Cosconati, Maria Zappalà
Publikováno v:
Molecules; Volume 27; Issue 12; Pages: 3765
Human African Trypanosomiasis (HAT) is an endemic protozoan disease widespread in the sub-Saharan region that is caused by T. b. gambiense and T. b. rhodesiense. The development of molecules targeting rhodesain, the main cysteine protease of T. b. rh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01322c81c16e5a3e1a702d0fc6c260c1
https://pubmed.ncbi.nlm.nih.gov/35744891
https://pubmed.ncbi.nlm.nih.gov/35744891
Autor:
Cleydson Finotti Cordeiro, Monica Fraccarolli Pelozo, Stefânia Neiva Lavorato, Luana Sueli Silva, Jamie Anthony Hawkes, Giovanna Fiori Serpa Lima, Lucas Lopardi Franco, Diogo Teixeira Carvalho, Ivo Santana Caldas
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021)
Background: The search for new drug compounds is always challenging and there are several different strategies that involve the most varied and creative approaches in medicinal chemistry. One of them is the technique of molecular hybridisation: formi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60532ed9f5803ce34faa352db02b7bd
https://pubmed.ncbi.nlm.nih.gov/34410908
https://pubmed.ncbi.nlm.nih.gov/34410908
Autor:
Luis Barbo Hernández-Portilla, Laura Castañeda-Partida, Irma Elena Dueñas-García, Bertha Guadalupe Ramírez-Cruz, Ángel Durán-Díaz, Zaira Yuriria Olvera-Romero, María Eugenia Heres-Pulido, César Mendoza-Martínez, Francisco Hernández-Luis, Miguel García-Salomé, Elías Piedra-Ibarra, Luis Felipe Santos-Cruz
Publikováno v:
Mutagenesis. 35:299-310
Chagas disease, caused by the protozoan Trypanosoma cruzi, has increased in the world due to migration, travelling and climate change; at present, the principal problem is that common trypanocidal agents have resulted in toxic or inconvenient side ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79659ea86e93862d6ff5f623dcfa8279
https://doi.org/10.1093/mutage/gez042
https://doi.org/10.1093/mutage/gez042
Autor:
Danielle Ferreira Dias, Ivo Santana Caldas, Camila Coelho Rodrigues, Fávero Reisdorfer Paula, Diogo Teixeira Carvalho, Thiago Belarmino de Souza
Publikováno v:
Chemical Biology & Drug Design. 95:124-129
The search for compounds with new structural scaffolds is an important tool to the discovery of new drugs against Chagas disease. We report herein the synthesis of 1,2,3-triazoles obtained from eugenol and di-hydroeugenol and their in vitro and in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd03feb6df4e95599f0b2573dc247fb8
https://doi.org/10.1111/cbdd.13628
https://doi.org/10.1111/cbdd.13628
Autor:
Samuel Delgado-Hernández, Atteneri López-Arencibia, José E. Piñero, David Tejedor, Ines Sifaoui, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Fernando García-Tellado, Jacob Lorenzo-Morales
Publikováno v:
Pharmaceuticals
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Volume 14
Issue 6
Pharmaceuticals, Vol 14, Iss 552, p 552 (2021)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Volume 14
Issue 6
Pharmaceuticals, Vol 14, Iss 552, p 552 (2021)
The neglected infection known as Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, results in more than 7000 deaths per year, with an increasing number of cases in non-endemic areas such as Europe or the United States. Moreover, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbda49f557e3010d0b605088e13a008e
http://europepmc.org/articles/PMC8228537
http://europepmc.org/articles/PMC8228537
Autor:
Maiara Amaral, Alexsandro Branco, Eric Umehara, Manoelito Coelho dos Santos Junior, Isabella Mary Alves Reis, Rodrigo Souza Conceição, Larissa de Mattos Oliveira, Thais A. Costa-Silva, João Henrique G. Lago, Andre G. Tempone
Publikováno v:
Chemistrybiodiversity. 18(9)
In the present study, five known γ-lactones (majoranolide B - 1, majorenolide - 2, majorynolide - 3, lincomolide D - 4, and isolinderanolide E - 5), as well as a new one (perseanolide - 6), were isolated from Persea fulva and P. americana. All isola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9193ca1efe7b407b701294f36fc4919
https://pubmed.ncbi.nlm.nih.gov/34254435
https://pubmed.ncbi.nlm.nih.gov/34254435