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Akademický článek

A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice.

Autor: Willett RA; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA., Tryndyak VP; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA., Hughes Hanks JM; Toxicologic Pathology Associates, Jefferson, AR, USA., Elkins L; Toxicologic Pathology Associates, Jefferson, AR, USA., Nagumalli SK; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA., Avigan MI; Office of Pharmacovigilance and Epidemiology, FDA-Center for Drug Evaluation and Research, Silver Spring, MD, USA., Ross SA; Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA., da Costa GG; Office of the Director, FDA-National Center for Toxicological Research, Jefferson, AR, USA., Beland FA; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA., Rusyn I; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA., Pogribny IP; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA. Electronic address: igor.pogribny@fda.hhs.gov.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2024 Oct; Vol. 491, pp. 117046. Date of Electronic Publication: 2024 Jul 29.

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Akademický článek

Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification.

Autor: Willett RA; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, Arkansas, USA., Tryndyak VP; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, Arkansas, USA., Beland FA; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, Arkansas, USA., Pogribny IP; Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, Arkansas, USA.

Publikováno v: Journal of environmental science and health. Part C, Toxicology and carcinogenesis [J Environ Sci Health C Toxicol Carcinog] 2024; Vol. 42 (1), pp. 74-92. Date of Electronic Publication: 2024 Jan 19.

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Akademický článek

Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound.

Autor: Rice PA; FDA/CFSAN/OFAS/DFCN, 5001 Campus Drive, HFS 275, College Park, MD, 20740, USA. Electronic address: penelope.rice@fda.hhs.gov., Kabadi SV; FDA/CFSAN/OFAS/DFCN, 5001 Campus Drive, HFS 275, College Park, MD, 20740, USA., Doerge DR; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Vanlandingham MM; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Churchwell MI; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Tryndyak VP; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Fisher JW; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Aungst J; FDA/CFSAN/OFAS/DFCN, 5001 Campus Drive, HFS 275, College Park, MD, 20740, USA., Beland FA; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA.

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Jan; Vol. 183, pp. 114333. Date of Electronic Publication: 2023 Dec 05.

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Akademický článek

Gene expression analyses reveal potential mechanism of inorganic arsenic-induced apoptosis in zebrafish.

Autor: Silva CS; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA., Kudlyk T; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA., Tryndyak VP; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA., Twaddle NC; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA., Robinson B; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA., Gu Q; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA., Beland FA; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA., Fitzpatrick SC; Office of the Center Director, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA., Kanungo J; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.

Publikováno v: Journal of applied toxicology : JAT [J Appl Toxicol] 2023 Dec; Vol. 43 (12), pp. 1872-1882. Date of Electronic Publication: 2023 Jul 27.

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Akademický článek

Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice.

Autor: Tryndyak VP; Division of Biochemical Toxicology, Food and Drug Administration-National Center for Toxicological Research, Jefferson, Arkansas., Willett RA; Division of Biochemical Toxicology, Food and Drug Administration-National Center for Toxicological Research, Jefferson, Arkansas., Nagumalli SK; Division of Biochemical Toxicology, Food and Drug Administration-National Center for Toxicological Research, Jefferson, Arkansas., Li D; Division of Bioinformatics and Biostatistics, Food and Drug Agency-National Center for Toxicological Research, Jefferson, Arkansas., Avigan MI; Office of Pharmacovigilance and Epidemiology, Food and Drug Administration-Center for Drug Evaluation and Research, Silver Spring, Maryland., Beland FA; Division of Biochemical Toxicology, Food and Drug Administration-National Center for Toxicological Research, Jefferson, Arkansas., Rusyn I; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas., Pogribny IP; Division of Biochemical Toxicology, Food and Drug Administration-National Center for Toxicological Research, Jefferson, Arkansas.

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2023 Mar 01; Vol. 324 (3), pp. G232-G243. Date of Electronic Publication: 2023 Jan 10.

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