Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Tryfon Zarganes-Tzitzikas"'
Autor:
Sohaib Nizami, Val Millar, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases. After priming and activation by inflammation triggers, NLRP3 for
Externí odkaz:
https://doaj.org/article/1fa617be6c444588bad302d2d3607a84
Autor:
Gonçalo S. Clemente, Jens Rickmeier, Inês F. Antunes, Tryfon Zarganes-Tzitzikas, Alexander Dömling, Tobias Ritter, Philip H. Elsinga
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Background Statins are lipid-lowering agents that inhibit cholesterol synthesis and are clinically used in the primary and secondary prevention of cardiovascular diseases. However, a considerable group of patients does not respond to statin
Externí odkaz:
https://doaj.org/article/23c106c6b3934e74b0ac4ab9403ca740
Autor:
Marion Schuller, Tryfon Zarganes-Tzitzikas, James Bennett, Stephane De Cesco, Daren Fearon, Frank von Delft, Oleg Fedorov, Paul E. Brennan, Ivan Ahel
Publikováno v:
Pathogens, Vol 12, Iss 2, p 324 (2023)
The worldwide public health and socioeconomic consequences caused by the COVID-19 pandemic highlight the importance of increasing preparedness for viral disease outbreaks by providing rapid disease prevention and treatment strategies. The NSP3 macrod
Externí odkaz:
https://doaj.org/article/d095de8ed820404392759fd4296b33f6
Autor:
Constantinos G. Neochoritis, Maryam Kazemi Miraki, Eman M. M. Abdelraheem, Ewa Surmiak, Tryfon Zarganes-Tzitzikas, Beata Łabuzek, Tad A. Holak, Alexander Dömling
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 513-520 (2019)
Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F19W23L25. The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclizati
Externí odkaz:
https://doaj.org/article/714269d16b8d497eab7b91bf23d416a7
Autor:
Domna Iordanidou, Michael G. Kallitsakis, Marina A. Tzani, Dimitris I. Ioannou, Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Alexander Dömling, Michael A. Terzidis, Ioannis N. Lykakis
Publikováno v:
Molecules, Vol 27, Iss 14, p 4395 (2022)
The synthesis of 3,4-dihydroquinoxalin-2-ones via the selective reduction of aromatic, multifunctional nitro precursors catalyzed by supported gold nanoparticles is reported. The reaction proceeds through the in situ formation of the corresponding am
Externí odkaz:
https://doaj.org/article/28e2485e8796495bad185d4eb026eb08
Autor:
Shabnam Shaabani, Louis Gadina, Ewa Surmiak, Zefeng Wang, Bidong Zhang, Roberto Butera, Tryfon Zarganes-Tzitzikas, Ismael Rodriguez, Justyna Kocik-Krol, Katarzyna Magiera-Mularz, Lukasz Skalniak, Alexander Dömling, Tad A. Holak
Publikováno v:
Molecules, Vol 27, Iss 11, p 3454 (2022)
New biphenyl-based chimeric compounds containing pomalidomide were developed and evaluated for their activity to inhibit and degrade the programmed cell death-1/programmed cell death- ligand 1 (PD-1/PD-L1) complex. Most of the compounds displayed exc
Externí odkaz:
https://doaj.org/article/67a2552841844f3d9aa8c069ce56167b
Autor:
Domna Iordanidou, Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Alexander Dömling, Ioannis N. Lykakis
Publikováno v:
ACS Omega, Vol 3, Iss 11, Pp 16005-16013 (2018)
Externí odkaz:
https://doaj.org/article/daf7ee767b62405689b444ad6175e7a6
Autor:
Sohaib Nizami, Val Millar, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/87b5d1c433174420bb315595d76f8e3d
Publikováno v:
Molecules, Vol 24, Iss 23, p 4210 (2019)
There is an unmet need for late-stage 18F-fluorination strategies to label molecules with a wide range of relevant functionalities to medicinal chemistry, in particular (hetero)arenes, aiming to obtain unique in vivo information on the pharmacokineti
Externí odkaz:
https://doaj.org/article/56a9a8d1f5104786936b75a9f187e9d7
Publikováno v:
Molecules, Vol 24, Iss 7, p 1327 (2019)
Imaging techniques, such as positron emission tomography (PET), represent great progress in the clinical development of drugs and diagnostics. However, the efficient and timely synthesis of appropriately labeled compounds is a largely unsolved proble
Externí odkaz:
https://doaj.org/article/13c5eaaea8244176b9f4c82b490e90ce