A transgenic mouse line for assaying tissue-specific changes in endoplasmic reticulum proteostasis.

Autor: Svarcbahs R; Cellular Stress and Inflammation Section, Intramural Research Program, National Institute On Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA., Blossom SM; Cellular Stress and Inflammation Section, Intramural Research Program, National Institute On Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA., Baffoe-Bonnie HS; Cellular Stress and Inflammation Section, Intramural Research Program, National Institute On Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA., Trychta KA; Cellular Stress and Inflammation Section, Intramural Research Program, National Institute On Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA., Greer LK; Cellular Stress and Inflammation Section, Intramural Research Program, National Institute On Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA., Pickel J; Transgenic Technology Core, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, 20892, USA., Henderson MJ; Cellular Stress and Inflammation Section, Intramural Research Program, National Institute On Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Harvey BK; Cellular Stress and Inflammation Section, Intramural Research Program, National Institute On Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA. bharvey@mail.nih.gov.

Publikováno v: Transgenic research [Transgenic Res] 2023 Jun; Vol. 32 (3), pp. 209-221. Date of Electronic Publication: 2023 May 03.

Computational Modeling of C-Terminal Tails to Predict the Calcium-Dependent Secretion of Endoplasmic Reticulum Resident Proteins.

Autor: Trychta KA; Molecular Mechanisms of Cellular Stress and Inflammation Unit, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States., Xie B; Computational Chemistry and Molecular Biophysics Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States., Verma RK; Computational Chemistry and Molecular Biophysics Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States., Xu M; Computational Chemistry and Molecular Biophysics Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States., Shi L; Computational Chemistry and Molecular Biophysics Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States., Harvey BK; Molecular Mechanisms of Cellular Stress and Inflammation Unit, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States.

Publikováno v: Frontiers in chemistry [Front Chem] 2021 Jun 29; Vol. 9, pp. 689608. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.

Autor: Henderson MJ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. Electronic address: mark.henderson2@nih.gov., Trychta KA; National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA., Yang SM; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Bäck S; National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA., Yasgar A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Wires ES; National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA., Danchik C; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Yan X; National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA., Yano H; National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA., Shi L; National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA., Wu KJ; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan 35053, Taiwan., Wang AQ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Tao D; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Zahoránszky-Kőhalmi G; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Hu X; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Xu X; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Maloney D; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Zakharov AV; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Rai G; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Urano F; Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University in St. Louis, St. Louis, MO 63110, USA., Airavaara M; Neuroscience Center, HiLIFE & Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Gavrilova O; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA., Jadhav A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Wang Y; Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan 35053, Taiwan., Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Harvey BK; National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address: bharvey@intra.nida.nih.gov.

Publikováno v: Cell reports [Cell Rep] 2021 Apr 27; Vol. 35 (4), pp. 109040.

KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency.

Autor: Trychta KA; Molecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA., Bäck S; Molecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA., Henderson MJ; Molecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA., Harvey BK; Molecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA. Electronic address: bharvey@intra.nida.nih.gov.

Publikováno v: Cell reports [Cell Rep] 2018 Nov 13; Vol. 25 (7), pp. 1829-1840.e6.

Longitudinal monitoring of Gaussia and Nano luciferase activities to concurrently assess ER calcium homeostasis and ER stress in vivo.

Autor: Wires ES; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, United States of America., Henderson MJ; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, United States of America., Yan X; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, United States of America., Bäck S; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, United States of America., Trychta KA; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, United States of America., Lutrey MH; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, United States of America., Harvey BK; Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, United States of America.

Publikováno v: PloS one [PLoS One] 2017 Apr 12; Vol. 12 (4), pp. e0175481. Date of Electronic Publication: 2017 Apr 12 (Print Publication: 2017).