Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Trx, thioredoxin"'
Publikováno v:
Translational Oncology, Vol 17, Iss, Pp 101341-(2022)
Translational Oncology
Translational Oncology
Highlights • Thioredoxin reductase (TrxR), a seleno enzyme, regulates cellular redox. • Several human cancers are known to overexpress TrxR. • Inhibitors of TrxR have enhanced radiation induced cytotoxicity in multiple cancers. • TrxR could b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaf62bdf3583fc4416746fca6cdfb01
http://www.sciencedirect.com/science/article/pii/S1936523322000031
http://www.sciencedirect.com/science/article/pii/S1936523322000031
Publikováno v:
The Journal of Biological Chemistry
Genetically encoded fluorescent H2O2 probes continue to advance the field of redox biology. Here, we compare the previously established peroxiredoxin-based H2O2 probe roGFP2-Tsa2ΔCR with the newly described OxyR-based H2O2 probe HyPer7, using yeast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad2bc52f4bdaeec9305224467f625768
https://pubmed.ncbi.nlm.nih.gov/34118234
https://pubmed.ncbi.nlm.nih.gov/34118234
Publikováno v:
The Journal of Biological Chemistry
Botulinum neurotoxins (BoNTs) are among the most widely used therapeutic proteins; however, only two subtypes within the seven serotypes, BoNT/A1 and BoNT/B1, are currently used for medical and cosmetic applications. Distinct catalytic properties, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63f4a9422b97519a0db73c3472043f3
http://europepmc.org/articles/PMC8135040
http://europepmc.org/articles/PMC8135040
Autor:
Jean-William Dupuy, Céline Léon, Frédéric Saltel, Sophie Collardeau-Frachon, Mathias Ruiz, Esra Karatas, Nathalie Senant, Marion Bouchecareilh, Sylvaine Di-Tommaso, Alain Lachaux, Anne-Aurélie Raymond
Publikováno v:
JHEP Reports
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (4), pp.100297. ⟨10.1016/j.jhepr.2021.100297⟩
JHEP Reports Innovation in Hepatology, 2021, 3 (4), pp.100297. ⟨10.1016/j.jhepr.2021.100297⟩
JHEP Reports, Vol 3, Iss 4, Pp 100297-(2021)
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (4), pp.100297. ⟨10.1016/j.jhepr.2021.100297⟩
JHEP Reports Innovation in Hepatology, 2021, 3 (4), pp.100297. ⟨10.1016/j.jhepr.2021.100297⟩
JHEP Reports, Vol 3, Iss 4, Pp 100297-(2021)
Background & Aims A single point mutation in the Z-variant of alpha 1-antitrypsin (Z-AAT) alone can lead to both a protein folding and trafficking defect, preventing its exit from the endoplasmic reticulum (ER), and the formation of aggregates that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948f690a1ce714d8e5a10b72ff26caa4
http://europepmc.org/articles/PMC8192868
http://europepmc.org/articles/PMC8192868
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, pp.100429. ⟨10.1016/j.jbc.2021.100429⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, pp.100429. ⟨10.1016/j.jbc.2021.100429⟩
The Journal of Biological Chemistry
The formation of a persulfide group (-SSH) on cysteine residues has gained attention as a reversible posttranslational modification contributing to protein regulation or protection. The widely distributed 3-mercaptopyruvate sulfurtransferases (MSTs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d2a1f1be4399098e61803ba8972aab97
https://hal.univ-lorraine.fr/hal-03157547
https://hal.univ-lorraine.fr/hal-03157547
Autor:
Jing Li, Shuang Li, Chaohua Tang, Tengfei Zhan, Qingyu Zhao, Kai Zhang, Xiaoqing Guo, Junmin Zhang, Yunsheng Han
Publikováno v:
Redox Biology
Redox Biology, Vol 36, Iss, Pp 101519-(2020)
Redox Biology, Vol 36, Iss, Pp 101519-(2020)
Selenium (Se) intake disequilibrium is associated with many human diseases (e.g., Keshan disease and type 2 diabetes). To understand the mechanism of Se deficiency-induced hepatic pathogenesis, a pure line pig model was established by feeding a diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c256895562836b68aac08f98cd61154a
http://europepmc.org/articles/PMC7287308
http://europepmc.org/articles/PMC7287308
Publikováno v:
Redox Biology, Vol 32, Iss, Pp-(2020)
Redox Biology
Redox Biology
Hepatocellular carcinoma (HCC) accounts for most of primary liver cancer, of which five-year survival rate remains low and chemoprevention has become a strategy to reduce disease burden of HCC. We aim to explore the in vivo chemopreventive effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80eb373f3f3770341d44824dda53c2b3
http://www.sciencedirect.com/science/article/pii/S2213231720304936
http://www.sciencedirect.com/science/article/pii/S2213231720304936
Publikováno v:
Shu, N, Cheng, Q, Arner, E S J & Davies, M J 2020, ' Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone ', Redox Biology, vol. 28, 101335 . https://doi.org/10.1016/j.redox.2019.101335
Redox Biology
Redox Biology, Vol 28, Iss, Pp-(2020)
Redox Biology
Redox Biology, Vol 28, Iss, Pp-(2020)
Quinones are common in nature, and often cytotoxic. Their proposed toxicity mechanisms involve redox cycling with radical generation, and/or reactions with nucleophiles, such as protein cysteine (Cys) residues, forming adducts via Michael addition re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deff0ff237c1dbe23349174a540bc470
https://curis.ku.dk/portal/da/publications/inhibition-and-crosslinking-of-the-selenoprotein-thioredoxin-reductase1-by-pbenzoquinone(eca1d1e1-ad99-41d7-8ae2-ef2076fe9b7e).html
https://curis.ku.dk/portal/da/publications/inhibition-and-crosslinking-of-the-selenoprotein-thioredoxin-reductase1-by-pbenzoquinone(eca1d1e1-ad99-41d7-8ae2-ef2076fe9b7e).html
Autor:
Christina Wilms, Klaudia Lepka, Felix Häberlein, Steven Edwards, Jörg Felsberg, Linda Pudelko, Tobias T. Lindenberg, Gereon Poschmann, Nan Qin, Katrin Volbracht, Tim Prozorovski, Sven G. Meuth, Ulf D. Kahlert, Marc Remke, Orhan Aktas, Guido Reifenberger, Lars Bräutigam, Benjamin Odermatt, Carsten Berndt
Publikováno v:
Redox Biology
Redox Biology, Vol 49, Iss, Pp 102221-(2022)
Redox Biology, Vol 49, Iss, Pp 102221-(2022)
Redox regulation of specific cysteines via oxidoreductases of the thioredoxin family is increasingly being recognized as an important signaling pathway. Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1264a8b55337ae59a0642c7caca10f50
https://doi.org/10.1016/j.redox.2021.102221
https://doi.org/10.1016/j.redox.2021.102221
Autor:
Kaori Okinaka, Goshi Shiota, Hiroyuki Oka, Tsuyoshi Yokobata, Shizuma Okazaki, Ikuya Noda, Minoru Morimoto, Noriko Itaba, Yohei Kono
Publikováno v:
Regenerative Therapy, Vol 9, Iss, Pp 45-57 (2018)
Regenerative Therapy
Regenerative Therapy
Introduction We previously reported that transplantation of hepatic cell sheets from human bone marrow-derived mesenchymal stem cells (BM-MSCs) with hexachlorophene, a Wnt/β-catenin signaling inhibitor, ameliorated acute liver injury. In a further p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d56c4d56ae22c9ffa2f008940c3783
http://www.sciencedirect.com/science/article/pii/S2352320418300142
http://www.sciencedirect.com/science/article/pii/S2352320418300142