Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Trupti Vardam"'
Autor:
Trupti Vardam-Kaur, Alma Banuelos, Maria Gabaldon-Parish, Bruna Gois Macedo, Caio Loureiro Salgado, Kelsey Marie Wanhainen, Maggie Hanqi Zhou, Sarah van Dijk, Igor Santiago-Carvalho, Angad S. Beniwal, Chloe L. Leff, Changwei Peng, Nhan L. Tran, Stephen C. Jameson, Henrique Borges da Silva
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110290- (2024)
Summary: Sensing of extracellular ATP (eATP) controls CD8+ T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin 1 (Panx1). Whether Panx1 controls CD8+ T cell immune responses in v
Externí odkaz:
https://doaj.org/article/bd022071210a4cfc9b97ed22f0917cb0
Autor:
Igor Santiago-Carvalho, Gislane Almeida-Santos, Bruna Gois Macedo, Caio Cesar Barbosa-Bomfim, Fabricio Moreira Almeida, Marcos Vinícios Pinheiro Cione, Trupti Vardam-Kaur, Mia Masuda, Sarah Van Dijk, Bruno Marcel Melo, Rogério Silva do Nascimento, Rebeka da Conceição Souza, Alba Lucínia Peixoto-Rangel, Robson Coutinho-Silva, Mario Hiroyuki Hirata, José Carlos Alves-Filho, José Maria Álvarez, Elena Lassounskaia, Henrique Borges da Silva, Maria Regina D’Império-Lima
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113448- (2023)
Summary: CD4+ T cells are key components of the immune response during lung infections and can mediate protection against tuberculosis (TB) or influenza. However, CD4+ T cells can also promote lung pathology during these infections, making it unclear
Externí odkaz:
https://doaj.org/article/fe5978ef17a34b0d8f92e8f6d5272a3f
Autor:
Joao Incio, Priya Suboj, Shan M Chin, Trupti Vardam-Kaur, Hao Liu, Tai Hato, Suboj Babykutty, Ivy Chen, Vikram Deshpande, Rakesh K Jain, Dai Fukumura
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0141392 (2015)
Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor desmoplasia. We have previously demonstrated that preventing the activation of pancreat
Externí odkaz:
https://doaj.org/article/b3ca4367ad574db591a996ff36751465
Autor:
Fumito Ito, Amy W Ku, Mark J Bucsek, Jason B Muhitch, Trupti Vardam-Kaur, Minhyung Kim, Daniel T Fisher, Marta Camoriano, Thaer Khoury, Joseph J Skitzki, Sandra O Gollnick, Sharon S Evans
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143370 (2015)
While surgical resection is a cornerstone of cancer treatment, local and distant recurrences continue to adversely affect outcome in a significant proportion of patients. Evidence that an alternative debulking strategy involving radiofrequency ablati
Externí odkaz:
https://doaj.org/article/30ddd6b0e3464a5daa61095a99011bf2
Akademický článek
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Autor:
Dominique B. Hoelzinger, Sophia J. Quinton, Denise K. Walters, Trupti Vardam-Kaur, Renee C. Tschumper, Henrique Borges da Silva, Diane F. Jelinek
Publikováno v:
Blood Advances. 6:3458-3471
Identifying factors secreted by multiple myeloma (MM) cells that may contribute to MM tumor biology and progression is of the utmost importance. In this study, hepatoma-derived growth factor (HDGF) was identified as a protein present in extracellular
Autor:
Trupti Vardam-Kaur, Sarah van Dijk, Changwei Peng, Kelsey M. Wanhainen, Stephen C. Jameson, Henrique Borges da Silva
Publikováno v:
J Immunol
Development of CD8+ central memory T (Tcm) and resident memory T (Trm) cells, which promote immunity in the circulation and in barrier tissues, respectively, is not completely understood. Tcm and Trm cells may arise from common precursors; however, t
Autor:
Sandra J. Gendler, Latha B. Pathangey, P. Leif Bergsagel, Trupti Vardam-Kaur, Daniel J. McCormick, Peter A. Cohen
Publikováno v:
Oncotarget. 12:2051-2067
Multiple Myeloma (MM) patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses. Here we evaluate the possibility of adoptive cell tr
Autor:
Igor Santiago-Carvalho, Gislane Almeida-Santos, Bruna Gois Macedo, Caio Cesar Barbosa-Bomfim, Fabricio Moreira Almeida, Marcos Vinícios Pinheiro Cione, Trupti Vardam-Kaur, Mia Masuda, Sarah Van Dijk, Bruno Marcel Melo, Rogério Silva do Nascimento, Rebeka da Conceição Souza, Alba Lucínia Peixoto-Rangel, Robson Coutinho-Silva, Mario H. Hirata, José Carlos Alves-Filho, José Maria Álvarez, Elena Lassounskaia, Henrique Borges da Silva, Maria Regina D’Império-Lima
CD4+ T cells are key components of the immune response during lung infections and can mediate protection against tuberculosis (TB) or influenza. However, CD4+ T cells can also promote lung pathology during these infections, making it unclear how thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cf093c16f1ab9ebf14025da85b0f9ee
https://doi.org/10.1101/2022.09.19.508603
https://doi.org/10.1101/2022.09.19.508603
Publikováno v:
Current Opinion in Pharmacology. 57:117-124
Intracellular metabolic adaptations help define the function and homeostasis of memory CD8+ T cells. These cells, which promote protection against infections or cancer, undergo consecutive metabolic shifts, ultimately relying on mitochondrial-related