Hepatic bile acid accretion correlates with cholestatic liver injury and therapeutic response in Cyp2c70 knockout mice with a humanized bile acid composition.

Autor: Klindt C; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine University, Duesseldorf, Germany.; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Truong JK; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.; Rectify Pharma, Cambridge, Massachusetts, United States., Bennett AL; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States., Pachura KJ; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States., Herebian D; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany., Mayatepek E; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany., Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine University, Duesseldorf, Germany., Ebert M; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Karpen SJ; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.; Stravitz-Sanyal Liver Institute for Liver Disease and Metabolic Health, Virginia Commonwealth University, Richmond, Virginia, United States., Dawson PA; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, United States.

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2024 Dec 01; Vol. 327 (6), pp. G789-G809. Date of Electronic Publication: 2024 Oct 01.

Active enterohepatic cycling is not required for the choleretic actions of 24-norUrsodeoxycholic acid in mice.

Autor: Truong JK; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Li J; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Li Q; Department of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA., Pachura K; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Rao A; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Gumber S; Division of Pathology and Laboratory Medicine, Yerkes National Research Center, Emory University School of Medicine, Atlanta, Georgia, USA., Fuchs CD; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Feranchak AP; Department of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA., Karpen SJ; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Dawson PA; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

Publikováno v: JCI insight [JCI Insight] 2023 Mar 22; Vol. 8 (6). Date of Electronic Publication: 2023 Mar 22.

Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.

Autor: Zaufel A; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria., van de Wiel SMW; Tytgat Institute for Liver and Intestinal Research, & Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, Metabolism (AGEM), Amsterdam University Medical Centers, the Netherlands., Yin L; The School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland., Fauler G; Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical, University of Graz, Austria., Chien D; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States of America., Dong X; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States of America., Gilmer JF; The School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland., Truong JK; Division of Pediatric Gastroenterology, Hepatology & Nutrition, Emory University School of Medicine, Atlanta, GA, USA., Dawson PA; Division of Pediatric Gastroenterology, Hepatology & Nutrition, Emory University School of Medicine, Atlanta, GA, USA., van de Graaf SFJ; Tytgat Institute for Liver and Intestinal Research, & Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, Metabolism (AGEM), Amsterdam University Medical Centers, the Netherlands., Fickert P; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria., Moustafa T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria. Electronic address: tarek.moustafa@meduni-graz.at.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2021 Aug 01; Vol. 1867 (8), pp. 166153. Date of Electronic Publication: 2021 Apr 22.