Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Trung Hai Nguyen"'
Autor:
Thuy Phuong Nguyen, Phuc Khoa Nguyen, Huu Ngu Nguyen, Thanh Duc Tran, Gia Tung Pham, Thai Hung Le, Dinh Huy Le, Trung Hai Nguyen, Van Binh Nguyen
Publikováno v:
Forest Science and Technology, Pp 1-13 (2024)
The combination of machine learning models with satellite imagery is becoming a popular data-modeling tool for biomass prediction, supporting land cover management. This study aims to select the most suitable model to estimate tropical forest abovegr
Externí odkaz:
https://doaj.org/article/f0dbd396400549b1b4a17c97d6caaa96
Publikováno v:
Royal Society Open Science, Vol 11, Iss 10 (2024)
Targeting acetylcholinesterase is one of the most important strategies for developing therapeutics against Alzheimer’s disease. In this work, we have employed a new approach that combines machine learning models, a multi-step similarity search of t
Externí odkaz:
https://doaj.org/article/456d7fd659f54220abe1c9097bde400e
Publikováno v:
Royal Society Open Science, Vol 9, Iss 1 (2022)
The umbrella sampling (US) simulation is demonstrated to be an efficient approach for determining the unbinding pathway and binding affinity to the SARS-CoV-2 Mpro of small molecule inhibitors. The accuracy of US is in the same range as the linear in
Externí odkaz:
https://doaj.org/article/9a5af88c244b4ba9b2eb0fb52c17567e
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273656 (2022)
Bayesian regression is performed to infer parameters of thermodynamic binding models from isothermal titration calorimetry measurements in which the titrant is an enantiomeric mixture. For some measurements the posterior density is multimodal, indica
Externí odkaz:
https://doaj.org/article/f2a608adff2545309470211ed3fa0339
Publikováno v:
Molecules, Vol 27, Iss 4, p 1395 (2022)
Alzheimer’s disease displays aggregates of the amyloid-beta (Aβ) peptide in the brain, and there is increasing evidence that cholesterol may contribute to the pathogenesis of the disease. Though many experimental and theoretical studies have focus
Externí odkaz:
https://doaj.org/article/6d67a7f28047431b9449eb72893d3698
Autor:
Ewald Weichselbaum, Maria Österbauer, Denis G. Knyazev, Oleg V. Batishchev, Sergey A. Akimov, Trung Hai Nguyen, Chao Zhang, Günther Knör, Noam Agmon, Paolo Carloni, Peter Pohl
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Proton diffusion along biological membranes is vitally important for cellular energetics. Here we extended previous time-resolved fluorescence measurements to study the time and temperature dependence of surface proton transport. We determin
Externí odkaz:
https://doaj.org/article/e79296c0e9db4ab09bce85c16733cc1a
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193454 (2018)
Proton transport at water/membrane interfaces plays a fundamental role for a myriad of bioenergetic processes. Here we have performed ab initio molecular dynamics simulations of proton transfer along two phosphatidylcholine bilayers. As found in prev
Externí odkaz:
https://doaj.org/article/92a40f7d291c4e749f093813de1f1ada
Autor:
Trung Hai Nguyen, Ariën S Rustenburg, Stefan G Krimmer, Hexi Zhang, John D Clark, Paul A Novick, Kim Branson, Vijay S Pande, John D Chodera, David D L Minh
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203224 (2018)
Isothermal titration calorimetry (ITC) is the only technique able to determine both the enthalpy and entropy of noncovalent association in a single experiment. The standard data analysis method based on nonlinear regression, however, provides unreali
Externí odkaz:
https://doaj.org/article/18f5005ec38b4fdb9b413060fb12dc72
Autor:
Trung Hai Nguyen, Phuong-Thao Tran, Ngoc Quynh Anh Pham, Van-Hai Hoang, Dinh Minh Hiep, Son Tung Ngo
Publikováno v:
ACS Omega. 7:20673-20682
Acetylcholinesterase (AChE) is one of the most important drug targets for Alzheimer's disease (AD) treatment. In this work, a machine learning model was trained to rapidly and accurately screen large chemical databases for the potential inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9789116ee41101c48338cec2e7e576f2
https://doi.org/10.1021/acsomega.2c00908
https://doi.org/10.1021/acsomega.2c00908
Publikováno v:
In Child Abuse & Neglect March 2015 41:158-169