CJ-15,696 and Its Analogs, New Furopyridine Antibiotics from the Fungus Cladobotryum varium: Fermentation, Isolation, Structural Elucidation, Biotransformation and Antibacterial Activities

Autor: Nakao Kojima, John W. Wong, Joyce A. Sutcliffe, Jeffrey C. Sims, Debra Decosta, Taisuke Inagaki, Yoon-Jeong Kim, Kiyoshi Tachikawa, Jon Bordner, Koen A. Dekker, Hideo Hirai, Shinichi Sakemi, Nobuji Yoshikawa, Yutaka Sugie, Akemi Sugiura, Truesdell Susan Jane, Yasuhiro Kojima

Publikováno v: The Journal of Antibiotics. 55:6-18

CJ-15,696 and 7 novel furopyridine antibiotics were isolated from the fungus Cladobotryum varium CL12284. Their structures were determined by X-ray crystallography and spectral analysis. Three biotransformed analogs were also prepared from CJ-15,696.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337399f0f0dd591f112b96b443e01647
https://doi.org/10.7164/antibiotics.55.6

Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum

Autor: Yasue Matsunaga, Hideo Hirai, Shinichi Sakemi, Yumiko Suzuki, Yasuhiro Kojima, Osamu Suga, Fukumatsu Aoki, Nakao Kojima, Toshiyuki Saito, Shuzo Watanabe, Adam A. Smogowicz, Taisuke Inagaki, Atsushi Nagahisa, Tatsuo Sakakibara, John W. Wong, Tetsujo Sujaku, Truesdell Susan Jane

Publikováno v: The Journal of antibiotics. 51(11)

A kappa opioid receptor binding inhibitor was isolated from the fermentation broth of a basidiomycete, Hericium ramosum CL24240 and identified as erinacine E (1). Three analogs of 1 were produced by fermentation in other media and by microbial biotra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0caaa366ae2916fcb62b7ef1c05f74a
https://pubmed.ncbi.nlm.nih.gov/9918390

Novel CCR1 antagonists with improved metabolic stability

Autor: Brown, Matthew F, Avery, Mike, Brissette, William H, Chang, J.H, Colizza, Kevin, Conklyn, Maryrose, DiRico, Amy P, Gladue, Ronald P, Kath, John C, Krueger, Suzanne S, Lira, Paul D, Lillie, Brett M, Lundquist, Greg D, Mairs, Erin N, McElroy, Eric B, McGlynn, Molly A, Paradis, Timothy J, Poss, Christopher S, Rossulek, Michelle I, Shepard, Richard M, Sims, Jeff, Strelevitz, Timothy J, Truesdell, Susan, Tylaska, Laurie A, Yoon, Kwansik, Zheng, Deye

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 3 May 2004 14(9):2175-2179

BIOTRANSFORMATIONS FOR A GREEN FUTURE.

Autor: Truesdell, Susan

Publikováno v: Chemical Engineering Progress; Oct2005, Vol. 101 Issue 10, p44-47, 4p, 1 Graph

CJ-15,696 and its analogs, new furopyridine antibiotics from the fungus Cladobotryum varium: fermentation, isolation, structural elucidation, biotransformation and antibacterial activities.

Autor: Sakemi S; Exploratory Medicinal Sciences, Pfizer Global Research and Development (PGRD)--Nagoya Laboratories, Pfizer Inc., Aichi, Japan. Shinichi.Sakemi@japan.pfizer.com, Bordner J, DeCosta DL, Dekker KA, Hirai H, Inagaki T, Kim YJ, Kojima N, Sims JC, Sugie Y, Sugiura A, Sutcliffe JA, Tachikawa K, Truesdell SJ, Wong JW, Yoshikawa N, Kojima Y

Publikováno v: The Journal of antibiotics [J Antibiot (Tokyo)] 2002 Jan; Vol. 55 (1), pp. 6-18.