Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Trudy Straetemans"'
Autor:
Guido J.J. Kierkels, Eline van Diest, Patricia Hernández-López, Wouter Scheper, Anja C.M. de Bruin, Elselien Frijlink, Tineke Aarts-Riemens, Sanne F.J. van Dooremalen, Dennis X. Beringer, Rimke Oostvogels, Lovro Kramer, Trudy Straetemans, Wolfgang Uckert, Zsolt Sebestyén, Jürgen Kuball
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 388-400 (2021)
T cell engineering strategies offer cures to patients and have entered clinical practice with chimeric antibody-based receptors; αβT cell receptor (αβTCR)-based strategies are, however, lagging behind. To allow a more rapid and successful transla
Externí odkaz:
https://doaj.org/article/41ed21d53f8d4312b23072193b1bc35e
γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults
Autor:
Anna Vyborova, Anke Janssen, Lucrezia Gatti, Froso Karaiskaki, Austin Yonika, Sanne van Dooremalen, Jasper Sanders, Dennis X. Beringer, Trudy Straetemans, Zsolt Sebestyen, Jürgen Kuball
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
γ9δ2T cells fill a distinct niche in human immunity due to the unique physiology of the phosphoantigen-reactive γ9δ2TCR. Here, we highlight reproducible TCRδ complementarity-determining region 3 (CDR3δ) repertoire patterns associated with γ9δ
Externí odkaz:
https://doaj.org/article/dfb5fbd35a32484d8ceb964287caa82a
Autor:
Inez Johanna, Trudy Straetemans, Sabine Heijhuurs, Zsolt Sebestyen, Jürgen Kuball, Eline van Diest, Patricia Hernández López, Angelo D Meringa, Anna Vyborova, Froso Karaiskaki, Jan Gumathi Bormin, Sanne van Dooremalen, Mara J T Nicolasen, Lucrezia C D E Gatti, Dennis X Beringer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/de666a740e2143a1a08f52a3ccd29c36
Autor:
Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Wouter Scheper, Laura Bongiovanni, Alain de Bruin, Dennis X. Beringer, Rimke Oostvogels, Trudy Straetemans, Zsolt Sebestyen, Jürgen Kuball
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
γδT cell receptors (γδTCRs) recognize a broad range of malignantly transformed cells in mainly a major histocompatibility complex (MHC)-independent manner, making them valuable additions to the engineered immune effector cell therapy that current
Externí odkaz:
https://doaj.org/article/e17f0e99771741b296928ed52e569024
Autor:
Inez Johanna, Trudy Straetemans, Sabine Heijhuurs, Tineke Aarts-Riemens, Håkan Norell, Laura Bongiovanni, Alain de Bruin, Zsolt Sebestyen, Jürgen Kuball
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Background γ9δ2T cells, which express Vγ9 and Vδ2 chains of the T cell receptor (TCR), mediate cancer immune surveillance by sensing early metabolic changes in malignant leukemic blast and not their healthy hematopoietic stem counterpart
Externí odkaz:
https://doaj.org/article/839223ba97394df696ea6b0bbf9d8090
Autor:
Anke Janssen, Eline van Diest, Anna Vyborova, Lenneke Schrier, Anke Bruns, Zsolt Sebestyen, Trudy Straetemans, Moniek de Witte, Jürgen Kuball
Publikováno v:
Viruses, Vol 14, Iss 1, p 117 (2022)
In the complex interplay between inflammation and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-HSCT), viral reactivations are often observed and cause substantial morbidity and mortality. As toxicity after allo-HS
Externí odkaz:
https://doaj.org/article/2322f1aa54704b9db02bce34b41fad08
Autor:
Maaike V. J. Braham, Monique C. Minnema, Tineke Aarts, Zsolt Sebestyen, Trudy Straetemans, Anna Vyborova, Jurgen Kuball, F. Cumhur Öner, Catherine Robin, Jacqueline Alblas
Publikováno v:
OncoImmunology, Vol 7, Iss 6 (2018)
Bone marrow niches support multiple myeloma, providing signals and cell-cell interactions essential for disease progression. A 3D bone marrow niche model was developed, in which supportive multipotent mesenchymal stromal cells and their osteogenic de
Externí odkaz:
https://doaj.org/article/d07485d338794a75bf4ea094870f2fa6
Autor:
Trudy Straetemans, Guido J. J. Kierkels, Ruud Doorn, Koen Jansen, Sabine Heijhuurs, Joao M. dos Santos, Anna D. D. van Muyden, Henri Vie, Béatrice Clemenceau, Reinier Raymakers, Moniek de Witte, Zsolt Sebestyén, Jürgen Kuball
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-recep
Externí odkaz:
https://doaj.org/article/93a04137f7c647068f287b3c812a65cb
Autor:
Trudy Straetemans, Mandy van Brakel, Sabine van Steenbergen, Marieke Broertjes, Joost Drexhage, Joost Hegmans, Bart N. Lambrecht, Cor Lamers, Pierre van Der Bruggen, Pierre G. Coulie, Reno Debets
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
Adoptive therapy with TCR gene-engineered T cells provides an attractive and feasible treatment option for cancer patients. Further development of TCR gene therapy requires the implementation of T-cell target epitopes that prevent “on-target” rea
Externí odkaz:
https://doaj.org/article/12890943695641fe9d079b8f6d04f558
Autor:
Moniek de Witte, Jojanneke Scheepstra, Naomi Weertman, Annet Daudeij, Lotte van der Wagen, Rimke Oostvogels, Colin de Haar, Henk-Jan Prins, Willem Dohmen, Carly Bartels-Wilmer, Inez Johanna, Zsolt Sebestyen, Jurgen Kuball, Trudy Straetemans
Publikováno v:
Blood. 140:12737-12739