Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Trudy Rodgers"'
Publikováno v:
Pediatric Research.
Background Iron deficiency is the primary cause of anemia in children. Intravenous (IV) iron formulations circumvent malabsorption and rapidly restore hemoglobin. Methods This Phase 2, non-randomized, multicenter study characterized the safety profil
Publikováno v:
American Journal of Gastroenterology. 115:S220-S220
Autor:
Trudy Rodgers, Malcolm Rowland
Publikováno v:
Pharmaceutical Research. 24:918-933
To use recently developed mechanistic equations to predict tissue-to-plasma water partition coefficients (Kpus), apply these predictions to whole body unbound volume of distribution at steady state (Vu(ss)) determinations, and explain the differences
Autor:
Malcolm Rowland, Trudy Rodgers
Publikováno v:
Journal of Pharmaceutical Sciences. 95:1238-1257
A key component of whole body physiologically based pharmacokinetic (WBPBPK) models is the tissue-to-plasma water partition coefficients (Kpu's). The predictability of Kpu values using mechanistically derived equations has been investigated for 7 ver
Autor:
Trudy Rodgers, Karin Jorga, Leon Aarons, Kayode Ogungbenro, Ivelina Gueorguieva, Malcolm Rowland
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 33:97-124
We address the problem of designing pharmacokinetic experiments in multivariate response situations. Criteria, based on the Fisher information matrix, whose inverse according to the Rao-Cramer inequality is the lower bound of the variance-covariance
Publikováno v:
Journal of Pharmaceutical Sciences. 94:1237-1248
The purpose of this research was to identify the major factors controlling the distribution of beta-blockers (acebutolol, betaxolol, bisoprolol, metoprolol, oxprenolol, pindolol, propranolol and timolol) in rats, across tissues, compounds and enantio
Publikováno v:
Journal of Pharmaceutical Sciences. 94:1259-1276
Tissue-to-plasma water partition coefficients (Kpu's) form an integral part of whole body physiologically based pharmacokinetic (WBPBPK) models. This research aims to improve the predictability of Kpu values for moderate-to-strong bases (pK(a) > or =
Publikováno v:
Journal of pharmaceutical sciences. 101(12)
A key parameter in whole-body physiologically based pharmacokinetic models is the tissue-to-plasma water partition coefficient ( K pu ), which is commonly assumed consistent across all species for all tissues for passively distributing drugs. Many dr
Publikováno v:
Journal of Pharmaceutical Sciences. 96:3151-3152
The original article to which this erratum refers was published in 2005; 94:1259–1276.
Autor:
Malcolm Rowland, Trudy Rodgers
Publikováno v:
Journal of Pharmaceutical Sciences. 96:3153-3154
The original article to which this erratum refers was published in 2006; 95:1238–1257.