Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Trudy F. Ramlall"'
1
Akademický článek
Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function
Autor: David Snead, Alex L. Lai, Rachel T. Wragg, Daniel A. Parisotto, Trudy F. Ramlall, Jeremy S. Dittman, Jack H. Freed, David Eliezer
Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)
Complexin is a small soluble presynaptic protein that interacts with neuronal SNARE proteins in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central helix of complexin is required for both the inhibition of spontaneous fusio
Externí odkaz: https://doaj.org/article/87ddc4fc6fcc4acc82fe50487948e671
Zobrazit plný text záznamu
2
Chemoenzymatic Semi‐synthesis Enables Efficient Production of Isotopically Labeled α‐Synuclein with Site‐Specific Tyrosine Phosphorylation
Autor: David Eliezer, Buyan Pan, Trudy F. Ramlall, Joo Hyung Park, Elizabeth Rhoades, E. James Petersson
Publikováno v: Chembiochem
Post-translational modifications (PTMs) can affect the normal function and pathology of α-synuclein (αS), an amyloid-fibril-forming protein linked to Parkinson's disease. Phosphorylation of αS Tyr39 has recently been found to display a dose-depend
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c85626942bfb9532d16c778c651b81
https://doi.org/10.1002/cbic.202000742
Zobrazit plný text záznamu
3
Membrane Binding Induces Distinct Structural Signatures in the Mouse Complexin-1C-Terminal Domain
Autor: Emily M. Grasso, Mayu S. Terakawa, Alex L. Lai, Ying Xue Xie, Trudy F. Ramlall, Jack H. Freed, David Eliezer
Publikováno v: Journal of Molecular Biology. 435:167710
Complexins play a critical role in regulating SNARE-mediated exocytosis of synaptic vesicles. Evolutionary divergences in complexin function have complicated our understanding of the role these proteins play in inhibiting the spontaneous fusion of ve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1c99ae51acc03b2adf04fe28ba03e4
https://doi.org/10.1016/j.jmb.2022.167710
Zobrazit plný text záznamu
4
BETA- AND GAMMA-SYNUCLEINS MODULATE SYNAPTIC VESICLE-BINDING OF ALPHA-SYNUCLEIN
Autor: David Eliezer, Yoonmi Na, Trudy F. Ramlall, Jacqueline Burré, Lauren E Komer, Vladimir L. Buchman, Kathryn E. Carnazza, Manu Sharma, André Pineda
SUMMARYα-Synuclein (αSyn), β-synuclein (βSyn), and γ-synuclein (γSyn) are abundantly expressed in the vertebrate nervous system. αSyn functions in neurotransmitter release via binding to and clustering synaptic vesicles and chaperoning of SNAR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e989ed709e89392b394008bf2c5bfedf
https://doi.org/10.1101/2020.11.19.390419
Zobrazit plný text záznamu
5
3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake
Autor: Guowei Su, Yuanyuan Xiao, Guy Lippens, Yanan Zhu, James M. Gibson, David Eliezer, Jing Zhao, Robert J. Linhardt, Xuehong Song, Xinyue Liu, Lianchun Wang, Trudy F. Ramlall, Fuming Zhang, Jian Liu, Chunyu Wang, Yongmei Xu, Zhangjie Wang
Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (5), pp.1818-1827. ⟨10.1002/anie.201913029⟩
Angewandte Chemie International Edition, 2020, 59 (5), pp.1818-1827. ⟨10.1002/anie.201913029⟩
Angew Chem Int Ed Engl
International audience; Prion-like transcellular spreading of tau in Alz-heimersD isease (AD) is mediated by tau binding to cell surface heparan sulfate (HS). However,t he structural determinants for tau-HS interaction are not well understood. Microa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016d8d8dbf1c3d587d3efcc5a556a4d6
https://hal.archives-ouvertes.fr/hal-03006247/document
Zobrazit plný text záznamu
8
Structural basis of sterol binding and transport by a yeast StARkin domain
Autor: Michael Timme, Kalpana Pandey, Bodo Levkau, Trudy F. Ramlall, Anant K. Menon, Jin Wu, Julian-Alexander Jentsch, Olga Boudker, Irene Kiburu, David Eliezer
Publikováno v: The Journal of biological chemistry. 293(15)
The StARkin superfamily comprises proteins with steroidogenic acute regulatory protein–related lipid transfer (StART) domains that are implicated in intracellular, non-vesicular lipid transport. A new family of membrane-anchored StARkins was recent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8826d978525c734ca5f0e7313f6115
https://pubmed.ncbi.nlm.nih.gov/29463678
Zobrazit plný text záznamu
9
Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function
Autor: Daniel A. Parisotto, Jack H. Freed, Jeremy S. Dittman, David Eliezer, Rachel T. Wragg, David Snead, Trudy F. Ramlall, Alex L. Lai
Publikováno v: Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Complexin is a small soluble presynaptic protein that interacts with neuronal SNARE proteins in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central helix of complexin is required for both the inhibition of spontaneous fusio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37eb72aa2b2071cd88abe18eff143ce6
https://pubmed.ncbi.nlm.nih.gov/28596722
Zobrazit plný text záznamu
10
The Lipid-binding Domain of Wild Type and Mutant α-Synuclein
Autor: David Eliezer, Trudy F. Ramlall, Peter P. Borbat, Jack H. Freed, Elka R. Georgieva
Publikováno v: Journal of Biological Chemistry. 285:28261-28274
α-Synuclein (αS) is linked to Parkinson disease through its deposition in an amyloid fibril form within Lewy Body deposits, and by the existence of three αS point mutations that lead to early onset autosomal dominant Parkinsonism. The normal funct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75a7fd64230ac9b346a9cb9a95e29ec4
https://doi.org/10.1074/jbc.m110.157214
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje