Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis

Autor: Christine R. Keenan, Shenna Y. Langenbach, Fernando Jativa, Trudi Harris, Meina Li, Qianyu Chen, Yuxiu Xia, Bryan Gao, Michael J. Schuliga, Jade Jaffar, Danica Prodanovic, Yan Tu, Asres Berhan, Peter V. S. Lee, Glen P. Westall, Alastair G. Stewart

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Transforming growth factor-beta (TGF-β) is a major mediator of fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). However, therapeutic global inhibition of TGF-β is limited by unwanted immunosuppression and mitral valve defects. We p

Externí odkaz: https://doaj.org/article/7b11f46807e747e7ab1fb956b23831a3

A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases

Autor: Yuxiu C. Xia, Shenna Y. Langenbach, Gavin E. Reid, Danica Prodanovic, Christine R. Keenan, Alastair G. Stewart, Trudi Harris, Guillermo Lopez-Campos, Meina Li, Qianyu Chen, Vinzenz Hofferek, Jonathan E. Mangum

Publikováno v: iScience, Vol 12, Iss, Pp 232-246 (2019)
iScience
Li, M, Keenan, C R, Lopez Campos, G, Mangum, J E, Chen, Q, Prodanovic, D, Xia, Y C, Langenbach, S Y, Harris, T, Hofferek, V, Reid, G E & Stewart, A G 2019, ' A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases. ', iScience, vol. 12, pp. 232-246 . https://doi.org/10.1016/j.isci.2019.01.023

Summary Impaired therapeutic responses to anti-inflammatory glucocorticoids (GC) in chronic respiratory diseases are partly attributable to interleukins and transforming growth factor β1 (TGF-β1). However, previous efforts to prevent induction of G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9124f59c59b68c709d6bfade601eac93
https://doi.org/10.1016/j.isci.2019.01.023

Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity

Autor: Peter Vee Sin Lee, Asres Berhan, Christopher Grainge, Michael Schuliga, Alastair G. Stewart, Shenna Y. Langenbach, Jade Jaffar, David W Waters, Darryl A. Knight, Glen P. Westall, Trudi Harris

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 312:L772-L782

In lung injury and disease, including idiopathic pulmonary fibrosis (IPF), extravascular factor X is converted into factor Xa (FXa), a coagulant protease with fibrogenic actions. Extracellular annexin A2 binds to FXa, augmenting activation of the pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f70324d57108191e4635b36bcdf4707
https://doi.org/10.1152/ajplung.00553.2016

Stiffness: A 'Master Regulator' of Human Lung Fibroblast Phenotypic Plasticity?

Autor: Peter Vee Sin Lee, Michael J. Wilson, Alastair G. Stewart, Jade Jaffar, Trudi Harris, Asres Berhan, Glen P. Westall, F. Jativa

Publikováno v: A19. LESS IDIOPATHIC: STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN IPF.

The aberrant accumulation of myofibroblasts is one of the key histopathological features of idiopathic pulmonary fibrosis (IPF). The suggested sources of myofibroblasts include: epithelial mesenchymal transition; recruitment and differentiation of ci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8429c7738cf1033a06727d22342210f
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1043

Glucocorticoid resistance of migration and gene expression in a daughter MDA-MB-231 breast tumour cell line selected for high metastatic potential

Autor: Yan Tu, Ebony R Fietz, Cameron N. Johnstone, Trudi Harris, Christine R. Keenan, Alastair G. Stewart, Guillermo Lopez-Campos

Publikováno v: Fietz, E R, Keenan, C R, López-Campos, G, Tu, Y, Johnstone, C N, Harris, T & Stewart, A G 2017, ' Glucocorticoid resistance of migration and gene expression in a daughter MDA-MB-231 breast tumour cell line selected for high metastatic potential ', Scientific Reports, vol. 7, 43774 . https://doi.org/10.1038/srep43774
Scientific Reports

Glucocorticoids are commonly used to prevent chemotherapy-induced nausea and vomiting despite a lack of understanding of their direct effect on cancer progression. Recent studies suggest that glucocorticoids inhibit cancer cell migration. However, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7bce2720891c65d99030c15b84a51d
https://pure.qub.ac.uk/en/publications/glucocorticoid-resistance-of-migration-and-gene-expression-in-a-daughter-mdamb231-breast-tumour-cell-line-selected-for-high-metastatic-potential(811a8887-9a7b-401a-b610-7eda1eeececf).html