Výsledky vyhledávání - "Trudey Nicklee"

Predictive and Pharmacodynamic Biomarker Studies in Tumor and Skin Tissue Samples of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Treated With Erlotinib

Autor: Jeremy A. Squire, Eric Winquist, Patricia P Reis, Yu Shyr, Trudey Nicklee, Paula Marrano, Lillian L. Siu, Shuo Chen, James Ho, Heidi Chen, Suzanne Kamel-Reid, David W. Hedley, Gregory R. Pond, Ming-Sound Tsao, Denis Soulières, Mark Agulnik, Janet Dancey, E. X. Chen, Gilda da Cunha Santos

Publikováno v: Journal of Clinical Oncology. 25:2184-2190

Purpose Pharmacodynamic tissue studies were conducted on a phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Levels of epidermal growth factor receptor (EGFR), downstre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32d91cf0b169ba263da09f2d6863924a
https://doi.org/10.1200/jco.2006.07.6554

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A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas

Autor: Lillian L. Siu, Walter Kocha, David W. Hedley, Ming-Sound Tsao, D. Singh, Trudey Nicklee, J. Kortmansky, Amit M. Oza, Gregory R. Pond, Sarit Aviel-Ronen, Lisa W. Le, Diana C. Birle, Janet Dancey, Arboine D, Glenwood D. Goss, Ignacio Duran, James Ho, H. Hirte

Publikováno v: British Journal of Cancer

Standard cytotoxic treatments for neuroendocrine tumours have been associated with limited activity and remarkable toxicity. A phase II study was designed to evaluate the efficacy, safety and pharmacodynamics of temsirolimus in patients with advanced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f43fd8cf67af5049501108d11d7d9b
https://doi.org/10.1038/sj.bjc.6603419

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A Phase II Trial with Pharmacodynamic Endpoints of the Proteasome Inhibitor Bortezomib in Patients with Metastatic Colorectal Cancer

Autor: Lillian L. Siu, Trudey Nicklee, Carol A. Townsley, Ming-Sound Tsao, Mary J. MacKenzie, Diana C. Birle, Mark Vincent, David W. Hedley, Helen Mackay, Pierre Major, Pam Degendorfer, Malcolm A.S. Moore, John W. Wright, Amit M. Oza

Publikováno v: Clinical Cancer Research. 11:5526-5533

Purpose: To evaluate the effects of the proteasome inhibitor bortezomib on tumor growth in patients with advanced colorectal cancer, and to explore the relationship between correlative studies and clinical outcome. Design: Bortezomib (1.3 mg/m2) was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18510123266127f4fc61f437ec79799
https://doi.org/10.1158/1078-0432.ccr-05-0081

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A high-resolution MACROscope with differential phase contrast, transmitted light, confocal fluorescence, and hyperspectral capabilities for large-area tissue imaging

Autor: Trudey Nicklee, David W. Hedley, S. Damaskinos, Paul Constantinou, Brian C. Wilson

Publikováno v: IEEE Journal of Selected Topics in Quantum Electronics. 11:766-777

Recent advances in imaging technology have contributed greatly to biological science. Confocal fluorescence microscopes can acquire two-dimensional and three-dimensional images of biological samples such as live or fixed cells and tissues. Specimens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::860467e17232f3a9bfc5e3e1cd23ebaa
https://doi.org/10.1109/jstqe.2005.857708

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Relations between non–protein sulfydryl levels in the nucleus and cytoplasm, tumor oxygenation, and clinical outcome of patients with uterine cervical carcinoma

Autor: Fernando Moreno-Merlo, Trudey Nicklee, David W. Hedley, Richard P. Hill, Melania Pintilie, Michael Milosevic, Anthony Fyles

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 61:137-144

Purpose The non–protein sulfydryls (NPSH) glutathione and cysteine are able to effect chemical repair of radiation-induced DNA damage, particularly under hypoxic conditions, and are implicated in radioresistance. The levels of NPSH in the nucleus a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94acddc895e068c7c0af2c8916d028ab
https://doi.org/10.1016/j.ijrobp.2004.02.020

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Differential effects of buthionine sulphoximine in hypoxic and non-hypoxic regions of human cervical carcinoma xenografts

Autor: David W. Hedley, Trudey Nicklee, Vojislav Vukovic

Publikováno v: Radiotherapy and Oncology. 60:69-73

Background and Purpose : Recently we reported increased glutathione (GSH) levels in hypoxic regions of ME 180 and SiHa cervical cancer xenografts. Since this association might act synergistically to protect from radiotherapy, we examined the differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe16d4808ed3ad3697fdc6dacdf9a31
https://doi.org/10.1016/s0167-8140(01)00331-0

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Effects of topoisomerase I inhibition on the expression of topoisomerase IIα measured with fluorescence image cytometry

Autor: David W. Hedley, Trudey Nicklee, Michael Crump

Publikováno v: Cytometry. 25:205-210

A fluorescence image cytometry technique was developed to measure the effects of topotecan, a topoisomerase I inhibitor, on the nuclear expression of topoisomerase IIα in a series of patients with refractory or relapsed acute myeloid leukemia (AML).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63ec417f7396118e1611e738eb790f9e
https://doi.org/10.1002/(sici)1097-0320(19961101)25:3<205::aid-cyto1>3.0.co

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Differential effects of depleting agents on cytoplasmic and nuclear non-protein sulphydryls: a fluorescence image cytometry study

Autor: Trudey Nicklee, David W. Hedley, M. Thomas

Publikováno v: British Journal of Cancer

The intracellular distribution of glutathione (GSH) was measured by a quantitative image cytometry method, using the sulphydryl-reactive agent mercury orange. This readily forms fluorescent adducts with GSH and other non-protein sulphydryls (NPSH), b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75180c16f3a2d2da5fcd0cb4342b8c1
http://europepmc.org/articles/PMC2034154

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The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer

Autor: Limei Sun, Lisa J. Martin, Ming-Sound Tsao, Lee Hulse-Smith, Jennifer Woo, Trudey Nicklee, Norman F. Boyd, Naomi Miller, Tong Li, Rama Khokha

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 14(2)

Background: We have examined the relationships between the measured properties of breast tissue and mammographic density and other risk factors for breast cancer, using breast tissue obtained at forensic autopsy and not selected for the presence of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2414d886e8c6216f56d4f9d9d8dfc08
https://pubmed.ncbi.nlm.nih.gov/15734956

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MACROscopic imaging of tumor xenografts using fluorescence, phase contrast, and transmitted light

Autor: Paul Constantinou, Trudey Nicklee, Brian C. Wilson, David W. Hedley, Savvas Damaskinos

Publikováno v: Photonics North 2004: Photonic Applications in Astronomy, Biomedicine, Imaging, Materials Processing, and Education.

Recent advances in imaging technology have contributed greatly to biological science. Confocal fluorescence microscopy (CFM) facilitates high-contrast 2D and 3D images of biological samples such as living cells, and frozen or fixed tissue sections. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7297dfd60e197fd56b2161d9515f9106
https://doi.org/10.1117/12.567467

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